Abstract:
BACKGROUND:The current pilot study compares the impact of an intravenous infusion of Ringer's lactate to an acetate-based solution with regard to acid-base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects have been reported when using acetate buffered solutions in hemodialysis, hemodynamics were also evaluated. METHODS:Twenty-four women who had undergone abdominal gynecologic surgery and who had received either Ringer's lactate (Strong Ion Difference 28 mmol/L; n = 12) or an acetate-based solution (Strong Ion Difference 36.8 mmol/L; n = 12) according to an established clinical protocol and its precursor were included in the investigation. After induction of general anesthesia, a set of acid-base variables, hemodynamic values and serum electrolytes was measured three times during the next 120 minutes. RESULTS:Patients received a mean dose of 4,054 ± 450 ml of either one or the other of the solutions. In terms of mean arterial blood pressure and norepinephrine requirements there were no differences to observe between the study groups. pH and serum HCO3- concentration decreased slightly but significantly only with Ringer's lactate. In addition, the acetate-based solution kept the plasma effective strong ion difference more stable than Ringer's lactate. CONCLUSIONS:Both of the solutions provided hemodynamic stability. Concerning consistency of acid base parameters none of the solutions seemed to be inferior, either. Whether the slight advantages observed for the acetate-buffered solution in terms of stability of pH and plasma HCO3- are clinically relevant, needs to be investigated in a larger randomized controlled trial.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Hofmann-Kiefer KF,Chappell D,Kammerer T,Jacob M,Paptistella M,Conzen P,Rehm Mdoi
10.1186/2047-783X-17-21subject
Has Abstractpub_date
2012-07-06 00:00:00pages
21eissn
0949-2321issn
2047-783Xpii
2047-783X-17-21journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE:The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-as...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-s4-268
更新日期:2009-12-07 00:00:00
abstract:OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-08-16 00:00:00
abstract:BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:2005-07-29 00:00:00
abstract::More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-20 00:00:00
abstract::We investigated the expression pattern of Jagged1 peptide in mandibular condylar cartilage, as a type of secondary cartilage. Mandibular condyle of ddY mice were fixed from embryonic day 15 (E15) through just after birth (equivalent to E19). Serial sections were examined using histological immunohistochemical (IHC) te...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-01-23 00:00:00
abstract::The aim of the study was to investigate whether cholecystokinin, neurotensin, and cholinergic mechanisms act as mediators of bile salt-stimulated exocrine pancreatic secretion. Ten fasting healthy subjects provided with a double-lumen tube received 2, 4, and 6 g cattle bile and 200, 400, and 600 mg Na-taurodeoxycholat...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-11-24 00:00:00
abstract::Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...
journal_title:European journal of medical research
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更新日期:2002-01-29 00:00:00
abstract:OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
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pub_type: 杂志文章,评审
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journal_title:European journal of medical research
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更新日期:2001-07-30 00:00:00
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journal_title:European journal of medical research
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更新日期:2004-08-31 00:00:00
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-08 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-15
更新日期:2013-06-03 00:00:00
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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doi:
更新日期:2007-03-26 00:00:00
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更新日期:2014-02-12 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-9-401
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-016-0214-0
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:1997-11-28 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:1995-12-18 00:00:00
abstract::Infant formulas containing medium chain triglycerides (MTC) have been used for the nutritional management of infants with fat malabsorption. The optimal proportion of MTC in the formula remains to be determined. Three infant formulas with varying proportion of MTC in the fat blend were studied in children with cystic ...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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更新日期:1998-08-18 00:00:00
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:1997-12-31 00:00:00
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journal_title:European journal of medical research
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更新日期:1999-05-26 00:00:00
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journal_title:European journal of medical research
pub_type: 总体
doi:
更新日期:2000-11-30 00:00:00