Abstract：
:Soluble cell adhesion molecules such as sICAM-1 in serum and other biological fluids are suggested as being useful diagnostic parameters for a variety of diseases. Since increased concentrations during diseases are frequently less pronounced compared to other parameters, we tested whether it would be necessary to align the time of blood collection during the course of a clinical trial. In the 9 volunteers of our trial we found a statistically significant effect at the point in time of blood collection and corresponding serum concentrations of sICAM-1 (p < 0.01). The deviation of the concentrations at a certain time from the daily mean in each individual was seen to be as high as 15%. Our data suggest that daytime variations of serum sICAM-1 concentrations should be taken into consideration when longitudinal observations are planned.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Rudloff S,Thomas C,Kunz Csubject
Has Abstractpub_date
1995-12-18 00:00:00pages
171-2issue
3eissn
0949-2321issn
2047-783Xjournal_volume
1pub_type
杂志文章abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2006-08-30 00:00:00
abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：:Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-07-28 00:00:00
abstract：:Gadolinium chelates are widely used in magnetic resonance imaging as contrast medium in patients with nephropathy. However, only few studies have investigated the effect of gadolinium on serum creatinine concentration and estimated GFR as surrogate markers of renal function. This study was performed to evaluate the ef...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-04-20 00:00:00
abstract：BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-06-28 00:00:00
abstract：BACKGROUND:Burkholderia cepacia strains have been known to possess the capability to cause serious infections especially in neonatal intensive care units (NICUs), and their multi-drug resistances become a severe threat in hospital settings. The aim of this investigation was to evaluate the B. cepacia complex infections...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-12-537
更新日期：2011-12-02 00:00:00
abstract：:More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-20 00:00:00
abstract：:Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-09-28 00:00:00
abstract：:Experiments in space have shown that T lymphocyte function is altered in more than 50% of space crew members. There is strong evidence that such effect is due to stress rather than to weightlessness per se. However the health of astronauts was never threatened so far. Experiments in-vitro with cultures of human periph...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-09-09 00:00:00
abstract：BACKGROUND:Current evidence regarding the prognostic relevance of urinary sodium-to-potassium ratio (Na-to-K ratio), as an indicator of diet quality is limited. This study was conducted to investigate whether urinary Na-to-K ratio could be related to habitual dietary patterns, in a general population. METHODS:This stu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-020-00476-5
更新日期：2021-01-06 00:00:00
abstract：:Basal cell carcinoma (BCC) is the most common skin cancer, occurring more frequently than malignancies of any other tissue or organ, either individually or in total. Medical treatment modalities of BCC offer cost reduction and clinical advantages in selected cases. Neomycin has been reported to have an important role ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-05-20 00:00:00
abstract：OBJECTIVE:To compare two reduced dose indinavir (IDV) + ritonavir (RTV) combinations guided by therapeutic drug monitoring (TDM) in treatment-naive HIV1-infected patients. METHODS:HIV1-infected treatment naive patients were prospectively randomized to treatment with IDV 600 mg or 400 mg BID each in combination with RT...
journal_title：European journal of medical research
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-07-26 00:00:00
abstract：BACKGROUND:Since the new 2009 guidelines for left subclavian artery (LSA) management using thoracic endovascular aortic repair (TEVAR), a few studies have been published about alternative LSA management. The objective of this study was to present the follow-up results of covered or revascularized LSA during TEVAR. MET...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0147-z
更新日期：2015-05-31 00:00:00
abstract：BACKGROUND:Fingertip injuries treated with occlusive dressings (ODs) lead to nearly scar-free, functionally, and aesthetically pleasing results. We hypothesized that paracrine factors in the wound fluid (secretome) may influence migration and proliferation of mesenchymal stem cells (MSCs) and fibroblasts and modulate t...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0357-2
更新日期：2018-12-26 00:00:00
abstract：BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-09-29 00:00:00
abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-06-30 00:00:00
abstract：INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-11-24 00:00:00
abstract：OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-017-0295-4
更新日期：2017-12-02 00:00:00
abstract：BACKGROUND:miRNAs are a class of small non-coding RNA molecules that play an important role in the pathogenesis of human diseases through negative regulation of gene expression. Although miRNA-10b (miR-10b) has been implicated in other tumors, its role in non-small cell lung cancer (NSCLC) is still unknown. The aim of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-41
更新日期：2013-11-12 00:00:00
abstract：:In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. But, in contrast to oral and intravenous administration drug delivery to the lungs is controlled by additional par...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-14-s4-71
更新日期：2009-12-07 00:00:00
abstract：BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0300-y
更新日期：2018-01-08 00:00:00
abstract：BACKGROUND:Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited. OBJECTIVE:To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. - METHODS:A retrospective study involving 24 conse...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-2-47
更新日期：2011-02-24 00:00:00
abstract：BACKGROUND:Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS:Ten human ce...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-8-337
更新日期：2010-08-20 00:00:00
abstract：BACKGROUND:Bone fracture is one of the most common physical injuries in which gene expression and the microenvironment are reprogramed to facilitate the recovery process. METHODS:By specific siRNA transfection and MTT assay, we evaluated the effects of metastasis-associated gene 1 (MTA1) in osteoblast growth. To show ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0084-x
更新日期：2015-02-03 00:00:00
abstract：BACKGROUND:Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic in...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/2047-783X-19-12
更新日期：2014-03-03 00:00:00
abstract：:A 70-year-old woman with a progressive dominant hemisphere syndrome but only mild hemiparesis and a normal brain scan (>3 hours from stroke onset) showed angiographic occlusion of the left anterior cerebral artery and the middle cerebral artery at its trifurcation with preservation of the rolandic artery. Intra-arteri...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-07-19 00:00:00
abstract：BACKGROUND:Increasing rates of prosthetic joint infection (PJI) have presented challenges for general practitioners, orthopedic surgeons and the health care system in the recent years. The diagnosis of PJI is complex; multiple diagnostic tools are used in the attempt to correctly diagnose PJI. Evidence-based algorithms...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-017-0245-1
更新日期：2017-03-09 00:00:00
abstract：BACKGROUND:In subtotal central retinal artery occlusion (CRAO), distinct retinal edema with acute onset irreversible visual loss is common. - METHODS:Clinical observation, fluorescein angiogram. - PATIENT:A 69-year-old patient presented with acute visual loss of his right eye. Risk factors for CRAO were arterial hype...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-01-31 00:00:00
abstract：:Pentalogy of Fallot is a rare cyanotic congenital heart disease characterized by biventricular origin of the aorta above a large ventricular septal defect, obstruction of the pulmonary outflow, right ventricular hypertrophy (tetralogy of Fallot), and an atrial septal defect. Mortality due to syncope, arrhythmia or con...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-06-28 00:00:00
abstract：BACKGROUND:Reporting of all serious adverse events (SAEs) is a requirement for regulatory approval of a drug. Can equally rigorous reporting standards be expected in studies of non-drug treatments and how can underreporting, if any, be detected and proven? Using data from our large-scale prospective cohort study of acu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-12-22 00:00:00
