Abstract：
BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinical signs of autonomic dysfunction and subject to autonomic testing. Heart rate variability (HRV) with 6 per minute deep breathing was performed between day 9 to 31 after onset of meningitis. Follow-up data were available in three cases. RESULTS:All patients showed clinical signs of autonomic dysfunction, including upper and lower gastrointestinal tract symptoms, orthostatic hypotension, and urinary retention. A reduced HRV was observed in 4 patients, with sustained sinus tachycardia in 2 of them. The minimum of the HRV was reached 9 to 20 days after onset of meningitis. In one patient, normalization of the HRV occurred within 3 months. CONCLUSION:Acute TBE can be associated with autonomic dysfunction including reduced HRV and tachycardia. Prospective studies are needed to analyze the incidence of autonomic dysfunction in TBE, and to clarify which patients have the highest risk for autonomic failure.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Kleiter I,Steinbrecher A,Flügel D,Bogdahn U,Schulte-Mattler Wsubject
Has Abstractpub_date
2006-06-30 00:00:00pages
261-5issue
6eissn
0949-2321issn
2047-783Xjournal_volume
11pub_type
杂志文章abstract：BACKGROUND:Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-β/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-β on osteoclastogenesis has been detected and STAT1/2 has been shown to i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0074-4
更新日期：2015-01-07 00:00:00
abstract：:Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...
journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2009-09-28 00:00:00
abstract：BACKGROUND:Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS:Ten human ce...
journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2010-08-20 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-11-29 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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更新日期：1997-06-16 00:00:00
abstract：:Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhi...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2002-09-30 00:00:00
abstract：OBJECTIVE:replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mutations in the viral ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-10-415
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journal_title：European journal of medical research
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doi：10.1186/2047-783X-18-43
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-11-30 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-15-s2-50
更新日期：2010-11-04 00:00:00
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journal_title：European journal of medical research
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doi：
更新日期：2007-04-26 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0300-y
更新日期：2018-01-08 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-08-18 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-03-26 00:00:00
abstract：:Over the last years the reality surrounding HIV-infection has undergone a considerable change with regard to the life expectancy of patients, and the plans they can make for their lives. Because the majority of the HIV positive population is of reproductive age, one of these plans might be to have children, often as a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-15 00:00:00
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journal_title：European journal of medical research
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doi：10.1186/s40001-015-0147-z
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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更新日期：2017-07-06 00:00:00
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journal_title：European journal of medical research
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更新日期：2009-03-17 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-04-30 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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更新日期：2009-11-24 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-30 00:00:00
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journal_title：European journal of medical research
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更新日期：2010-02-26 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-05-29 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0289-2
更新日期：2017-11-15 00:00:00
