Abstract：
:Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We demonstrate that in an animal model topically applied retinyl palmitate can be taken up by the mucosal cells independently from the systemic supply. Under in vivo conditions metabolic changes in vaginal epithelium of rats were shown to be reversed by treatment with topical retinyl palmitate. - After only two days treatment squamous metaplastic vaginal epithelium in rats shows a reversal of the epithelium into a normal phenotype which continues after cessation of the treatment for 7 to 11 days. Higher concentrations and longer retention times lead to a statistically significant (p = 0.025) increase in the protection time. These data demonstrate that squamous changes induced by vitamin A deficiency can be totally reversed with topically applied retinyl palmitate.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Biesalski HK,Sobeck U,Weiser Hsubject
Has Abstractpub_date
2001-09-28 00:00:00pages
391-8issue
9eissn
0949-2321issn
2047-783Xjournal_volume
6pub_type
杂志文章abstract：:The shared care paradigm is the current response to the crisis of industrial countries' health systems. The underlying information systems have to meet the shared care paradigm of communication and co-operation between all the partners involved in. This communication and co-operation must be provided in a secure way. ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-08-18 00:00:00
abstract：BACKGROUND:Data on lung volumes and changes in flow-volume spirometry at high altitude are few and do not provide comprehensive assessment of the occurring changes. This study characterizes alterations of the forced expiratory flow-volume curve (FEFV-curve) and lung volumes at increasing altitude. METHODS:FEFV-curve a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-11-16 00:00:00
abstract：:Fluid shift after entering into microgravity, but also under equivalent flight conditions leads to enormous increase of intraocular pressure. To assess this precisely position - and gravity independent, handsome, automatic tonometers have been developed (German-Spacelab D1-Mission, German-Spacelab D2-Mission, German-R...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-01-26 00:00:00
abstract：INTRODUCTION:Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of developing steatosis and subsequent hepatocellular inflammation. We aimed to assess hepatic mitochondrial function by a non-invasive (13)C-methionine breath test (...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：BACKGROUND:A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility stu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0333-x
更新日期：2018-07-31 00:00:00
abstract：BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-06-28 00:00:00
abstract：:The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient. This lesion was purportedly preceded by multiple radiolucencies which were diagnosed as radicular cysts and treated a few times in the past years by ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-3-135
更新日期：2010-03-30 00:00:00
abstract：BACKGROUND:Graft-versus-host disease (GVHD) after liver and kidney transplantation has high mortality and causes diagnostic challenges. This study aims to describe the cytokine and human leukocyte antigen (HLA) profile in the GVHD after liver and kidney transplantation. METHODS:A high-throughput detection kit was appl...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0232-y
更新日期：2016-10-12 00:00:00
abstract：AIM:We have investigated CsA induced liver hyperplasia to explore the potential effects on the immunogenicity of the regenerating liver within the clinical context of rejection after transplantation. MATERIALS AND METHODS:Flow cytometry analysis of hepatocytes, isolated 48 hours after 2/3 partial hepatectomy (PH2/3) o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-04-30 00:00:00
abstract：:The current report describes the experience from the Frankfurt AIDS Cohort Study with patients suffering from renal failure. The clinical data of 4993 HIV-infected patients between 1983 and 1998 were analyzed retrospectively. Patients were seen at least twice a year and clinical features, routine laboratory results, i...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-23 00:00:00
abstract：:Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-193
更新日期：2010-11-04 00:00:00
abstract：:A 62-year-old white male presented with facial erythema and jugular vein distension in upright position which progressed to cyanosis and facial edema while keeping both arms elevated (Pemberton sign). A CT scan revealed a large substernal goiter as the cause of superior vena cava syndrome. Symptoms and signs disappear...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-11-28 00:00:00
abstract：OBJECTIVE:given sparse research on the issue, this study sought to shed light upon the interactions of alexithymia, emotion processing, and social anxiety in adults with attention-deficit hyperactivity disorder (ADHD). SUBJECTS AND METHODS:73 German adults with ADHD according to DSM-IV diagnostic criteria participated...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-9-403
更新日期：2010-09-24 00:00:00
abstract：AIM:The aim of the in vitro study was to examine the effect of estradiol and progesterone on the proliferation rate of human gingival fibroblasts (HGF) derived from a healthy and a diabetic (type II) individual. METHODS:In the first experiment, cells in the logarithmic proliferative phase were incubated with estradiol...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-12-09 00:00:00
abstract：:We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-11-20 00:00:00
abstract：:Invasive aspergillosis and disseminated candidiasis are the two major manifestations of opportunistic invasive mycoses. Their incidence has risen considerably during the past decades, due to more intensive anticancer chemotherapy, organ transplantations, intensive care, and aggressive surgical interventions. Especiall...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-31 00:00:00
abstract：BACKGROUND:A great variety of dental materials are now available for use in restorative treatments. Much attention has been devoted to physical and chemical properties, but the biological effects of these materials have been less frequently studied. AIM:The aim of this study is to test the influence of resin based res...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-10-29 00:00:00
abstract：BACKGROUND:Electroacupuncture is well known for its advantageous neuroanalgesic and therapeutic effects on myocardial ischemia-reperfusion injury. The purpose of the present research was to verify whether electroacupuncture can alleviate bupivacaine-induced myocardial injury. METHODS:Specific pathogen-free Wistar rats...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-020-00431-4
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:This study is a pre-planned country-specific subanalysis of results in Germany from a multinational multicenter registry to prospectively assess real-world experience with caspofungin administered for treatment of proven or probable invasive aspergillosis (IA). METHODS:Data from patients treated with caspof...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-7
更新日期：2012-04-17 00:00:00
abstract：:Possible effects of electromagnetic fields on human brain activity were studied. In a single-blind, cross-over-designed and placebo-controlled study 36 volunteers were exposed firstly to an electromagnetic field originating form a MediLine "MEGA-WAVE 150/1" therapy instrument and secondly to a field originating from a...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-10-16 00:00:00
abstract：BACKGROUND:In pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC-CPR). The proper performance of the procedure is a survival pr...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0369-6
更新日期：2019-02-08 00:00:00
abstract：BACKGROUND:Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. METHODS:We downloaded the gene expression...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-15
更新日期：2013-06-03 00:00:00
abstract：OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-017-0295-4
更新日期：2017-12-02 00:00:00
abstract：BACKGROUND:The concept of total mesorectal excision has revolutionised rectal cancer surgery. TME reduces the rate of local recurrence and tumour associated mortality. However, in clinical trials only 50% of the removed rectal tumours have an optimal TME quality. PATIENTS:During a period of 36 months we performed 103 ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-7-292
更新日期：2010-01-01 00:00:00
abstract：:The history and todays knowledge on the pathogenesis of arteriosclerosis emphasizing the importance of cholesterol concentration in plasma for the development of atherosclerosis is summarized. For proving the lipid hypothesis careful patient observation and new findings of molecular biology have added important inform...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-16 00:00:00
abstract：:The influence of heparin on Polymorphonuclear (PMN s) leukocytes was investigated using a new whole-blood cytofluorometric method (patent granted for the test with the number P 4334935.8-41) with Candida albicans and Staphylococcus aureus as test microorganisms. After comparing the effect of equal volumes of two widel...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-12-31 00:00:00
abstract：BACKGROUND:The Orthogonal Polarization Spectral (OPS) imaging technique has been introduced for in vivo assessment of microcirculation in humans. Unclear remains, whether the new technique would allow for accurate investigations of the colon microcirculation with respect to the unique conditions of the microvasculature...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-12-17 00:00:00
abstract：:Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan. On her admission to the hospital, she had a temperature of 38.2 degrees C with canker sore. Prior to the commencement of chemotherapy, peripher...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-03-31 00:00:00
abstract：:Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agent...
journal_title：European journal of medical research
pub_type： 总体
doi：
更新日期：2000-11-30 00:00:00
abstract：:Right ventricle (RV) dysfunction is a key outcome determinant and a leading cause of death for patients with chronic thromboembolic pulmonary hypertension (CTEPH). In this report, we followed the 5-year clinical journey of a patient with CTEPH. The tricuspid pressure gradient was significantly increased in the early p...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0112-x
更新日期：2015-03-02 00:00:00
