Abstract:
OBJECTIVE:Efavirenz (EFV) plasma levels have been discussed as a predictor of treatment failure in HIV infected patients. The aim of this prospective, open-labeled, case-control study was to evaluate pretreated patients in regards to efavirenz plasma levels and efficacy of therapy. METHODS:Blood samples were obtained monthly from 33 patients receiving efavirenz in combination with other antiretroviral agents for at least 3 months. EFV plasma concentrations and potease inhibitor (PI) plasma levels were measured by high-performance liquid chromatography (HPLC). EFV plasma levels were correlated with efficacy. In patients with virologic failure genotypic resistance testing was performed. RESULTS:Mean efavirenz plasma levels (n = 240) of 33 patients were 3.119 +/- 2.497 ng/ml. There were no significant differences between median efavirenz plasma levels of 24 patients (72%) with a HIV-RNA < 20 copies/ml (2.168 ng/ml), 3 patients with HIV-RNA of 20 500 copies/ml (3.362 ng/ml), and 6 patients with a virologic failure (>500 copies/ml) (2.190 ng/ml) respectively. Efavirenz plasma levels below 1.000 ng/ml were found in 4/27 effective treated patients, and in 4/6 patients with virologic failure. In all patients with virologic failure multiple NRTI, NNRTI and PI mutations were found in genotypic resistance testing. CONCLUSION:An individual EFV plasma level below 1.000 ng/ml in one single measurement seems to be predictive of viral failure and the developement of genotypic resistance. Therapeutic drug monitoring of EFV might be helpful, especially in heavily pretreated patients, to reach long term sufficently effectiveness of therapy.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Langmann P,Weissbrich B,Desch S,Väth T,Schirmer D,Zilly M,Klinker Hsubject
Has Abstractpub_date
2002-07-24 00:00:00pages
309-14issue
7eissn
0949-2321issn
2047-783Xjournal_volume
7pub_type
临床试验,杂志文章abstract:BACKGROUND:Patients with human immunodeficiency virus (HIV) infection have an increased risk of cardiovascular diseases. Previous publications described pericardial effusion as one of the most common HIV-associated cardiac affiliations. The aim of the current study was to investigate if pericardial effusion still has a...
journal_title:European journal of medical research
pub_type: 杂志文章,多中心研究
doi:10.1186/2047-783x-16-11-480
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abstract::The prevalence of high plasmatic levels of homocysteine in hypertensive patients with mild renal dysfunction (MRD) defined by 2003 European Hypertension Society Guidelines (men plasmatic creatinine between 1.3 and 1.5; women plasmatic creatinine between 1.2 and 1.4 mg/dl) has not been previously reported. To evaluate ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-05-26 00:00:00
abstract:BACKGROUND:In subtotal central retinal artery occlusion (CRAO), distinct retinal edema with acute onset irreversible visual loss is common. - METHODS:Clinical observation, fluorescein angiogram. - PATIENT:A 69-year-old patient presented with acute visual loss of his right eye. Risk factors for CRAO were arterial hype...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-01-31 00:00:00
abstract::Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-10-22 00:00:00
abstract:BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-06-30 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio grou...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0285-6
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-11-24 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
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abstract:BACKGROUND:In intestinal epithelium, tyrosine kinase receptor Ephrin B3 (Eph B3) maintains the architecture of the crypt-villus axis by repulsive interaction with its ligand ephrin-B1. While loss of Eph B3 is linked to colorectal cancer initiation, overexpression of Eph B3 in cancer cell lines inhibits growth and induc...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-10
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journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-12-14 00:00:00
abstract:BACKGROUND:Prosthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-020-00428-z
更新日期:2020-08-18 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-09-12 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2007-07-26 00:00:00
abstract::Exposure to high concentrations of oxygen is known to induce changes in lung function through effects on several pulmonary cell types, including alveolar macrophages (AM). In this study, we studied the in vitro effects of hyperoxia on the release of proinflammatory cytokines and the expression of surface receptors in ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1997-04-21 00:00:00
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pub_type: 杂志文章,meta分析
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abstract:BACKGROUND:Acute lung injury (ALI) is a serious clinical syndrome with a high rate of mortality. In this study, the effects of triptolide on lipopolysaccharide (LPS)-induced ALI in rats were investigated. METHODS:Sixty-five male Sprague Dawley rats(approved by ethics committee of the First Affiliated Hospital of Sooch...
journal_title:European journal of medical research
pub_type: 杂志文章,收录出版
doi:10.1186/2047-783X-18-58
更新日期:2013-12-17 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-016-0236-7
更新日期:2016-10-26 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:2014-02-12 00:00:00
abstract::Unilateral papillitis caused by Treponema pallidum was found in an immunocompetent homosexual patient with severe vision loss who had received previous antibiotics treatment. Syphilis-related ocular manifestation is more common in the early stages of the disease and it can be associated with a central nervous system l...
journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章,meta分析
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更新日期:2020-09-04 00:00:00
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-08 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1995-12-18 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-11-20 00:00:00