Abstract：
BACKGROUND:The Orthogonal Polarization Spectral (OPS) imaging technique has been introduced for in vivo assessment of microcirculation in humans. Unclear remains, whether the new technique would allow for accurate investigations of the colon microcirculation with respect to the unique conditions of the microvasculature in that particular tissue. Therefore, the aim of this study was to validate the new technique against intravital fluorescence microscopy (IFM) for the visualization of colon microcirculation in a murine model of inflammatory bowel disease (IBD). METHOD:IBD was induced in Balb/c mice by dextran sulfate sodium (DSS), controls received normal water. In each animal, both the CYTO-SCAN A/R and IFM were used to image the microcirculation (n = 7 in each group). Postcapillary venular diameter, venular red blood cell velocity (RBC-V) and functional capillary density (FCD) were analyzed on the colon muscularis and mucosa and compared to each other using linear regression analysis and Bland-Altman plots. RESULTS:All parameters correlated significantly between the both methods. The venular diameters and the RBC-V were significantly different between control and colitis group in contrast to FCD; these results were present while using both methods. CONCLUSION:Our study demonstrates that the new technique for visualization of microcirculation without use of fluorescent dyes, the OPS-imaging, allows for quantitative measurement of the key microcirculatory parameters of the mouse colon.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Biberthaler P,Langer S,Luchting B,Khandoga A,Messmer Ksubject
Has Abstractpub_date
2001-12-17 00:00:00pages
525-34issue
12eissn
0949-2321issn
2047-783Xjournal_volume
6pub_type
杂志文章abstract：BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
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abstract：:Five patients with non-cytotoxic drug-induced agranulocytosis were treated with recombinant human granulocyte-colony-stimulating factor (rh-G-CSF). The drugs involved were dipyrone, captopril, clozapine and carbimazole. Bone marrow examination revealed a depleted granulopoiesis with normal erythro- and megakaryocytopo...
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