Abstract：
:Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of thyroid disease in these patients, but no studies have evaluated for a coexistence of endocrine factors. In particular, no studies have attempted to evaluate for concurrent thyroid disease, obesity and long-term estrogen exposure in patients. 88 patients attending the Pulmonary Hypertension Association 8th International meeting completed a questionnaire and were interviewed. Information was collected regarding reproductive history, height, weight, and previous diagnosis of thyroid disease. 46% met criteria for obesity. 41% reported a diagnosis of thyroid disease. 81% of women reported prior use of hormone therapy. 70% reported greater than 10 years of exogenous hormone use. 74% of female patients reported two or more of potentially disease modifying endocrine factors (obesity, thyroid disease or estrogen therapy). The coexistent high prevalence in our cohort of exogenous estrogen exposure, thyroid disease and obesity suggests that an interaction of multiple endocrine factors might contribute to the pathogenesis of pulmonary hypertension and may represent epigenetic modifiers in genetically-susceptible individuals.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Sweeney L,Voelkel NFdoi
10.1186/2047-783x-14-10-433subject
Has Abstractpub_date
2009-09-28 00:00:00pages
433-42issue
10eissn
0949-2321issn
2047-783Xjournal_volume
14pub_type
杂志文章abstract：OBJECTIVE:Oxygen therapy is used for the treatment of various diseases, but prolonged exposure to high concentrations of O(2) is also associated with formation of free radicals and oxidative damage. METHODS:In the present study we compared alpha-ketoglutarate dehydrogenase (KGDH) activity and mitochondrial oxidative d...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-s4-116
更新日期：2009-12-07 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the association between leisure-time physical activity (LPA) and the risk of metabolic syndrome (MS). METHODS:Prospective cohort studies of the association between LPA and the risk of MS were retrieved from the PubMed and Embase databases up to 12 August 2013. The sta...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1186/2047-783X-19-22
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abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
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abstract：BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
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abstract：:In the course of infection by the Human Immunodeficiency Virus (HIV) typical changes of inflammatory periodontal diseases can arise. The prevalence of these illnesses may be up to 5%. The HIV-associated periodontal diseases include linear gingival erythema (LGE), necrotizing ulcerative gingivitis (NUG) and necrotizing...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
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journal_title：European journal of medical research
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doi：10.1186/s40001-020-00476-5
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journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
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journal_title：European journal of medical research
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doi：10.1186/2047-783x-14-5-223
更新日期：2009-05-14 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0369-6
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-03-26 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-23 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2019-11-26 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-30 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-02-26 00:00:00
