Abstract：
:Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms. A long, fully active isoform of Ob-Rb is expressed mainly in the hypothalamus, where it takes part in energy homeostasis and in the regulation of secretory organs' activity. Ob-Rb is also present on all types of immune cells, involved in innate and adaptive immunity. Short leptin isoforms (Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re) that contain box 1 motif are able to bind JAK kinases (Janus kinases) as well as to activate some other signal transduction cascades. A soluble isoform (Ob-Re) can regulate serum leptin concentration and serve as a carrier protein delivering the hormone to its membrane receptors and is able to transduce the signal into the cell. JAK/STAT pathway plays the major role in leptin signal transduction through membrane receptors. Among all Ob-R isoforms, only full-length isoform (Ob-Rb) is able to fully transduce activation signal into the cell.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Gorska E,Popko K,Stelmaszczyk-Emmel A,Ciepiela O,Kucharska A,Wasik Mdoi
10.1186/2047-783x-15-s2-50subject
Has Abstractpub_date
2010-11-04 00:00:00pages
50-4eissn
0949-2321issn
2047-783Xjournal_volume
15 Suppl 2pub_type
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
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pub_type： 杂志文章,meta分析
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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