Abstract:
:The European Directive 98/79/EC on in vitro diagnostic medical devices (IVD) stipulates the marketing and post market surveillance of IVD in the European Economic Area. In cases of issues and field corrective actions, the manufacturers have to inform the responsible Competent Authorities (CA). In Germany, the Federal Institute for Drugs and Medical Devices (BfArM) is the responsible CA for most IVD, with a small subset of IVD for immune hematological and infectiological testing as well as tissue typing as specified in Annex II of the Directive, being within the responsibility of the Paul-Ehrlich-Institute (PEI). In this study, all issues regarding laboratory analyzers for infection testing and their consumables, but not reagents, kits and general culture media, reported to the BfArM between begin 1999 and end of 2007 were analyzed in respect to the sources of report, the underlying product failure and the performed corrective actions. Within the observation period a total of 1471 reports for IVD were received of which 73 related to the IVD for infection testing were included in our study. Reports were predominantly received from manufacturers (56) and competent authorities (15). Affected products were most frequently those for immunological analysis (42) whereas those based on culturing techniques (17) and molecular biological techniques (14) played only minor roles. In all these groups, laboratory analyzers (55) were more frequently affected than their consumables (18). Investigations of the manufacturers were able to identify the underlying root causes of product failures in 62 cases (84.9%). In 2 cases (2.7%) the root cause remained unclear and in 9 cases (12.3%) a product failure was excluded or a user error was the underlying cause. Product failures in laboratory analyzers were most frequently caused by software errors (31) and constructional faults (8) whereas the predominant cause of product failure in consumables were errors in production and quality control (8). Manufacturers issued corrective measures in 66 cases (90.4%) from which 49 and 17 were related to laboratory analyzers and their consumables, respectively. Based on the underlying root causes of product failures these were predominantly customer information (48), recalls (40), software-updates (30) and design changes (9) in the product group of laboratory analyzers as well as customer information (16), recalls (12) and modifications of production and quality management (11) in the group of consumables. The results and experiences obtained since 1999 suggest that the system for post marketing surveillance of IVD is an established tool to ensure product safety, even though the current system can be further enhanced.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Siekmeier R,Halbauer J,Mientus W,Wetzel Ddoi
10.1186/2047-783x-14-s4-216subject
Has Abstractpub_date
2009-12-07 00:00:00pages
216-26eissn
0949-2321issn
2047-783Xjournal_volume
14 Suppl 4pub_type
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journal_title:European journal of medical research
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abstract::We report the case of a 64-year old woman with severe attacks of allergic alveolitis occurring frequently independent of a concrete place. These attacks were regularely preceded by diarrhoe. Laboratory data showed marked leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an inc...
journal_title:European journal of medical research
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章,评审
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更新日期:2010-11-30 00:00:00
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更新日期:2008-05-26 00:00:00
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:2007-03-26 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-s4-27
更新日期:2009-12-07 00:00:00
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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