Abstract：
:Antibiotic-resistant organisms causing both hospital- and community-acquired complicated skin and soft-tissue infections (cSSTI) are increasingly reported. A substantial medical and economical burden associated with MRSA colonisation or infection has been documented. The number of currently available appropriate antimicrobial agents is limited. Good quality randomised, controlled clinical trial data on antibiotic efficacy and safety is available for cSSTI caused by MRSA. Linezolid, tigecycline, daptomycin and vancomycin showed efficacy and safety in MRSA-caused cSSTI. None of these drugs showed significant superiority in terms of clinical cure and eradication rates.To date, linezolid offers by far the greatest number of patients included in controlled trials with a strong tendency of superiority over vancomycin in terms of eradication and clinical success.. - Tigecycline is an alternative in polymicrobial infections except by diabetic foot infections. Daptomycin might be a treatment option for cases of cSSTI with MRSA bacteremia. cSSTI caused by resistant Gram-negative bacteria are a matter of great concern. The development of new antibiotics in this area is an urgent priority to avoid the risk of a postantibiotic era with no antimicrobial treatment options. An individual approach for every single patient is mandatory to evaluate the optimal antimicrobial treatment regimen.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Eckmann C,Dryden Mdoi
10.1186/2047-783x-15-12-554subject
Has Abstractpub_date
2010-11-30 00:00:00pages
554-63issue
12eissn
0949-2321issn
2047-783Xjournal_volume
15pub_type
杂志文章,评审abstract：:The aim of the study was to investigate whether cholecystokinin, neurotensin, and cholinergic mechanisms act as mediators of bile salt-stimulated exocrine pancreatic secretion. Ten fasting healthy subjects provided with a double-lumen tube received 2, 4, and 6 g cattle bile and 200, 400, and 600 mg Na-taurodeoxycholat...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Resternotomy in cardiac surgery is considered a risk factor for postoperative complications. Previous studies have demonstrated an ambiguous relationship between resternotomy and clinical outcomes. Registry data from a mixed population of durable circulatory support devices suggest that history of cardiac su...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0289-2
更新日期：2017-11-15 00:00:00
abstract：BACKGROUND:In intestinal epithelium, tyrosine kinase receptor Ephrin B3 (Eph B3) maintains the architecture of the crypt-villus axis by repulsive interaction with its ligand ephrin-B1. While loss of Eph B3 is linked to colorectal cancer initiation, overexpression of Eph B3 in cancer cell lines inhibits growth and induc...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-10
更新日期：2012-05-14 00:00:00
abstract：:The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-05-24 00:00:00
abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-06-30 00:00:00
abstract：:The immunological environment of leukemic blasts in the bone marrow might play a decisive role in determining an individual's risk for relapse. In order to identify potential predictors of relapse and to elucidate the mechanisms of immune control of leukemic blasts we examined the expression of cytokines, costimulator...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-03-27 00:00:00
abstract：:Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-21 00:00:00
abstract：:Fluid shift after entering into microgravity, but also under equivalent flight conditions leads to enormous increase of intraocular pressure. To assess this precisely position - and gravity independent, handsome, automatic tonometers have been developed (German-Spacelab D1-Mission, German-Spacelab D2-Mission, German-R...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-01-26 00:00:00
abstract：OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/2047-783x-14-4-171
更新日期：2009-04-16 00:00:00
abstract：:Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART, ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
abstract：:The purpose of the present study was to evaluate clinically the effect of an anaesthetic gel (lidocaine 20 mg/g as active agent) on pain sensitivity and early wound healing following nonsurgical periodontal therapy. A total of 40 patients with chronic periodontitis were enrolled in this randomized, split-mouth, double...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-05-29 00:00:00
abstract：OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-5-223
更新日期：2009-05-14 00:00:00
abstract：:More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-20 00:00:00
abstract：OBJECTIVES:The present study was carried out to assess compliance rates with annual colorectal cancer screening for fecal occult blood, and to identify the subjects with higher priority in health education to increase screen compliance. DESIGN AND SETTING:A screening program for colorectal cancer was conducted between...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-07-20 00:00:00
abstract：:The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-3-106
更新日期：2009-03-17 00:00:00
abstract：:Experiments in space have shown that T lymphocyte function is altered in more than 50% of space crew members. There is strong evidence that such effect is due to stress rather than to weightlessness per se. However the health of astronauts was never threatened so far. Experiments in-vitro with cultures of human periph...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-09-09 00:00:00
abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：:We report the case of a 64-year old woman with severe attacks of allergic alveolitis occurring frequently independent of a concrete place. These attacks were regularely preceded by diarrhoe. Laboratory data showed marked leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an inc...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-03-27 00:00:00
abstract：BACKGROUND:Prostate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-36
更新日期：2013-10-03 00:00:00
abstract：:Five patients with non-cytotoxic drug-induced agranulocytosis were treated with recombinant human granulocyte-colony-stimulating factor (rh-G-CSF). The drugs involved were dipyrone, captopril, clozapine and carbimazole. Bone marrow examination revealed a depleted granulopoiesis with normal erythro- and megakaryocytopo...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
abstract：BACKGROUND:Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. METHODS:We downloaded the gene expression...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-15
更新日期：2013-06-03 00:00:00
abstract：BACKGROUND:Data on lung volumes and changes in flow-volume spirometry at high altitude are few and do not provide comprehensive assessment of the occurring changes. This study characterizes alterations of the forced expiratory flow-volume curve (FEFV-curve) and lung volumes at increasing altitude. METHODS:FEFV-curve a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-11-16 00:00:00
abstract：:Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan. On her admission to the hospital, she had a temperature of 38.2 degrees C with canker sore. Prior to the commencement of chemotherapy, peripher...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-03-31 00:00:00
abstract：OBJECTIVE:This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS:A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0313-1
更新日期：2018-05-03 00:00:00
abstract：:The authors report a large duodenal somatostatinoma, a very rare tumor entity. A 8.5 cm globular mass in the area of the unicate process of the pancreas was detected in a 45 year old caucasian female by computerized tomography. The patient had only mild complaints. Initial treatment consisted of right pancreatectomy w...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-03-29 00:00:00
abstract：:Basal cell carcinoma (BCC) is the most common skin cancer, occurring more frequently than malignancies of any other tissue or organ, either individually or in total. Medical treatment modalities of BCC offer cost reduction and clinical advantages in selected cases. Neomycin has been reported to have an important role ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-05-20 00:00:00
abstract：:In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. But, in contrast to oral and intravenous administration drug delivery to the lungs is controlled by additional par...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-14-s4-71
更新日期：2009-12-07 00:00:00
abstract：:Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhi...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2002-09-30 00:00:00
abstract：BACKGROUND:This study is a pre-planned country-specific subanalysis of results in Germany from a multinational multicenter registry to prospectively assess real-world experience with caspofungin administered for treatment of proven or probable invasive aspergillosis (IA). METHODS:Data from patients treated with caspof...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-7
更新日期：2012-04-17 00:00:00
