Abstract：
BACKGROUND:There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majority is only applicable to a specific pathology. Therefore, the objective of our study was to develop and validate the Munich Ankle Questionnaire (MAQ) as a universal self-assessment score including subjective and objective items. METHODS:The established McGuire Score, Bray Score, Ankle Hindfoot Score (AOFAS) and Olerud and Molander Score were analyzed for relevant items and subscales. Items of interest were then condensed and allocated to the respective subscales of the MAQ. The final MAQ consists of 6 items addressing general and demographic data and 12 items addressing three domains: pain (3 items), work and daily living (5 items), movement and ROM (4 items). The evaluation of validity, reliability and responsiveness of the MAQ was performed in a prospective clinical study including traumatic as well as degenerative ankle pathologies. RESULTS:In total, 148 patients (79 female, 69 male, median age 45 years) were included in the validation study. With intra-class correlation coefficients of at least 0.77, test-retest reliability was proven. Construct validity with a correlation coefficient of 0.82 and responsiveness with a correlation coefficient ranging from 0.42 to 0.47 were confirmed. CONCLUSION:The MAQ is a reliable and valid self-assessment measurement tool for the follow-up examination regarding subjective and objective parameters of traumatic and degenerative ankle pathologies. The MAQ has no limitation to specific disorders and allows a broad application.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Greve F,Braun KF,Vitzthum V,Zyskowski M,Müller M,Kirchhoff C,Biberthaler P,Beirer Mdoi
10.1186/s40001-018-0344-7subject
Has Abstractpub_date
2018-09-28 00:00:00pages
46issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-018-0344-7journal_volume
23pub_type
杂志文章abstract：AIMS:This study assessed the prevalence of substance use among Iranian patients with cardiovascular disease who were admitted in different cardiac wards at Shiraz general hospitals. DESIGN:Cross-sectional survey using structured interview and also using DSM-IV criteria for substance dependency. SETTING:General hospit...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2002-02-21 00:00:00
abstract：:Previous studies on Langerhans'-cell histiocytosis (LCH) were mostly retrospective and patients had been recruited over a long time period. The aim of the present study was to establish data on the clinical presentation, diagnosis and treatment of currently affected patients. Data on the clinical history, diagnostic w...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-11-29 00:00:00
abstract：INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-11-24 00:00:00
abstract：:Targeted intrapulmonary delivery of drugs may reduce systemic toxicity, improve treatment efficacy, but inhaled drugs may also interfere with pulmonary surfactant function. We hypothesized that the lipophilic drug amphotericin B used to treat or prevent pulmonary infections with aspergillus species, might destroy surf...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-08-18 00:00:00
abstract：OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-5-223
更新日期：2009-05-14 00:00:00
abstract：:Five patients with non-cytotoxic drug-induced agranulocytosis were treated with recombinant human granulocyte-colony-stimulating factor (rh-G-CSF). The drugs involved were dipyrone, captopril, clozapine and carbimazole. Bone marrow examination revealed a depleted granulopoiesis with normal erythro- and megakaryocytopo...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
abstract：:Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...
journal_title：European journal of medical research
pub_type：
doi：
更新日期：2002-01-29 00:00:00
abstract：:In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-10-30 00:00:00
abstract：:Infant formulas containing medium chain triglycerides (MTC) have been used for the nutritional management of infants with fat malabsorption. The optimal proportion of MTC in the formula remains to be determined. Three infant formulas with varying proportion of MTC in the fat blend were studied in children with cystic ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-02-21 00:00:00
abstract：BACKGROUND:Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-β/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-β on osteoclastogenesis has been detected and STAT1/2 has been shown to i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0074-4
更新日期：2015-01-07 00:00:00
abstract：OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/2047-783x-14-4-171
更新日期：2009-04-16 00:00:00
abstract：:The history and todays knowledge on the pathogenesis of arteriosclerosis emphasizing the importance of cholesterol concentration in plasma for the development of atherosclerosis is summarized. For proving the lipid hypothesis careful patient observation and new findings of molecular biology have added important inform...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-16 00:00:00
abstract：:The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-3-106
更新日期：2009-03-17 00:00:00
abstract：BACKGROUND:Recent studies were able to demonstrate involvement of the complement cascade in bone biology. Further studies analyzed the role of complement in traumatic injuries and demonstrated negative effects after excessive systemic activation of the inflammatory response with early abrogation of complement activatio...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0236-7
更新日期：2016-10-26 00:00:00
abstract：:A number of neurodegenerative diseases including Parkinson's disease (PD) have been shown to be associated with polymorphic variants of mitochondrial DNA. The A4336G mutation in the tRNA(Gln) gene was reported to occur at a higher frequency in individuals with Parkinson's disease and Alzheimer's disease (AD) than in a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-03-24 00:00:00
abstract：BACKGROUND:Serotonin (5-HT) and its receptors are present in central, the brain stem, and peripheral, the carotid body, tissues controlling the ventilatory responses to hypoxia. The exact action of serotonin and its nature are, however, unsettled. We hypothesized that the discrepant results on the ventilatory action of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-128
更新日期：2010-11-04 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-08-17 00:00:00
abstract：BACKGROUND:Chondral or osteochondral lesions, post-traumatic contracture and loose bodies of the elbow are often associated with chronic pain, stiffness, repetitive swelling and joint blockages. Therefore, arthroscopy of the elbow is often used in the elderly for the treatment of osteochondral defects or arthrolysis. T...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0338-5
更新日期：2018-09-15 00:00:00
abstract：OBJECTIVES:At workplaces, organic solvents are often used as mixtures. Nevertheless, there is limited knowledge of their acute effects on human central nervous system. Here we report the effects of a toluene-acetone mixture. METHODS:In a parallel design, subgroups of 12 healthy men each were exposed to a mixture conta...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-09-12 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-12-07 00:00:00
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journal_title：European journal of medical research
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doi：
更新日期：2000-08-18 00:00:00
abstract：:The immunological environment of leukemic blasts in the bone marrow might play a decisive role in determining an individual's risk for relapse. In order to identify potential predictors of relapse and to elucidate the mechanisms of immune control of leukemic blasts we examined the expression of cytokines, costimulator...
journal_title：European journal of medical research
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更新日期：2006-03-27 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0214-0
更新日期：2016-05-06 00:00:00
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journal_title：European journal of medical research
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更新日期：1996-09-20 00:00:00
abstract：BACKGROUND:Renal impairment is a common complication of multiple myeloma occurring in up to 50 % of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation (vasoconstriction) in the kidneys with measurable elevation of the resistance index among these p...
journal_title：European journal of medical research
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更新日期：2010-05-18 00:00:00
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journal_title：European journal of medical research
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doi：10.1186/2047-783X-17-21
更新日期：2012-07-06 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1999-02-25 00:00:00
abstract：OBJECTIVE:replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mutations in the viral ...
journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2010-10-25 00:00:00
