Abstract：
:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. It is believed that its soluble form (sICAM-1) might be a serum parameter of inflammatory activity with possible relevance in granulomatous disorders. To evaluate this role we measured sICAM-1 by ELISA in serum and shedding of this molecule by BAL cells in patients with granulomatous lung diseases (pulmonary tuberculosis (TB), hypersensitivity pneumonitis (HSP), pulmonary sarcoidosis (PS), and controls). Serum concentrations of sICAM-1 in patients with TB (496.9 +/- 49.7 ng/ml), with HSP (636.5 +/- 85.9.8 ng/ml), and with PS (588.3 +/- 72.2 ng/ml) were significantly increased compared to controls (275.7 +/- 33.1 ng/ml). Spontaneous release of sICAM-1 by BAL cells differed among patient groups (TB: 9.3 +/- 1.7; HSP: 17.5 +/- 1.4; PS: 9.7 +/- 1.5 ng/ml), however, exceeding that of controls significantly (3.8 +/- 0.6 ng/ml). No correlations between the circulating level and the shedding of this molecule by BAL cells were observed within the groups. Significant correlations between serum sICAM-1 and serum tumor necrosis factor alpha (TNFalpha) level were observed in patients with HSP and TB. Kinetic cell culture experiments with BAL cells revealed a dissociation in sICAM-1 shedding and TNFalpha release. After stimulation rapid upregulation of both molecules (5 h) was followed by a cessation of TNFalpha production at 28 h. sICAM-1 shedding, however, was maintained over 2 days. Our results evidence that the circulating pool of sICAM-1, as well as the shedding of this molecule by BAL cells reflect the activity of cells in the inflammatory processes of granulomatous diseases.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Bäumer I,Zissel G,Schlaak M,Müller-Quernheim Jsubject
Has Abstractpub_date
1998-06-17 00:00:00pages
288-94issue
6eissn
0949-2321issn
2047-783Xjournal_volume
3pub_type
杂志文章abstract：:Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-07-28 00:00:00
abstract：:The prevalence of high plasmatic levels of homocysteine in hypertensive patients with mild renal dysfunction (MRD) defined by 2003 European Hypertension Society Guidelines (men plasmatic creatinine between 1.3 and 1.5; women plasmatic creatinine between 1.2 and 1.4 mg/dl) has not been previously reported. To evaluate ...
journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2008-05-26 00:00:00
abstract：:Coronary angiograms performed at the time of an acute coronary syndrome typically present vessel occlusions, ruptured plaques or thrombotic lesions that require reperfusion therapy. However, occasionally, no coronary artery stenoses are detected. Myocardial ischemia frequently causes left ventricular wall motion abnor...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-08-18 00:00:00
abstract：:Progressive infantile spastic tetraparesis spans a wide spectrum of partially rare differential diagnoses. Based on a clinical example the differential diagnostic thoughts are discussed in detail. Though juvenile motor neuron disease is a rare entity, it has to be kept in mind for differential diagnostics in cases of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-10-27 00:00:00
abstract：PURPOSE:Evaluation of MR-guided interstitial laser thermotherapy (ILT) of colorectal liver metastases under consideration of efficacy, safety and patient survival. MATERIALS AND METHODS:Sixty-six inoperable patients with a total of 117 colorectal liver metastases were treated with MR-guided laser therapy in 96 session...
journal_title：European journal of medical research
pub_type： 杂志文章
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更新日期：2007-04-26 00:00:00
abstract：BACKGROUND/OBJECTIVE:The continuous interaction of blood with artificial contact surfaces under cardiopulmonary bypass can lead to a substantial damage of blood cells and plasma factors. Surface biopolymers in oxygenation systems can help increasing the hemocompatibility, often combined with anticoagulative agents such...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
abstract：:The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-05-24 00:00:00
abstract：BACKGROUND:There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majori...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0344-7
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abstract：:In the course of infection by the Human Immunodeficiency Virus (HIV) typical changes of inflammatory periodontal diseases can arise. The prevalence of these illnesses may be up to 5%. The HIV-associated periodontal diseases include linear gingival erythema (LGE), necrotizing ulcerative gingivitis (NUG) and necrotizing...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-26 00:00:00
abstract：:Long-term pneumotachographic measurements in newborns are hampered by the apparatus dead space, which can be functionally eliminated by a constant bias flow (flow-through technique). In a clinical study the influence of this bias flow was investigated. - In 80 infants (group 1:20 healthy controls, group 2: 30 infants ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-01-26 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-15-12-554
更新日期：2010-11-30 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-15
更新日期：2013-06-03 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-11-24 00:00:00
abstract：OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-017-0295-4
更新日期：2017-12-02 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-05-26 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-01-29 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-12-17 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-28 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-30 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-s4-116
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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doi：
更新日期：2007-12-14 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-04-08 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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doi：
更新日期：2001-07-30 00:00:00
abstract：INTRODUCTION:Azathioprine has variable efficacy in inflammatory bowel disease. Previous studies suggested that either neutropenia, an increase in the mean corpuscular volume, the assessment of thiopurine methyl-transferase activity or erythrocyte 6-thioguanine values might predict the treatment response. However, due t...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-12-07 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-03-27 00:00:00
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journal_title：European journal of medical research
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doi：
更新日期：2007-02-26 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-11-25 00:00:00
