Abstract：
PURPOSE:In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compared with definite radio(chemo)therapy in patients <75 years. METHODS:32 patients >75 years were treated with definite radio(chemo)therapy for EC. We compared baseline parameters, efficiency and toxicity rates of these patients to 39 patients <75 years. RESULTS:Patients <75 years were more likely to receive simultaneous chemotherapy, and had a lower age-adjusted Charlson comorbidity index (ACCI). 25% of elderly patients were treated in palliative intent. There was no significant difference in progression-free survival between patient groups. No significant differences were seen for overall survival (15.7 months vs. 19.9 months; p = 0.102) and progression-free survival (10.5 months vs. 9.2 months, p = 0.470) between older patients treated with curative intent and younger patients. In addition, there were no significant differences for dysphagia and hematological side effects between elderly patients and younger patients. CONCLUSION:Definite (chemo)radiation is a feasible therapy for elderly patients. OS and PFS in elderly patients with a curative treatment approach are comparable to younger patients and it is not associated with higher toxicity rates.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Münch S,Heinrich C,Habermehl D,Oechsner M,Combs SE,Duma MNdoi
10.1186/s40001-017-0265-xsubject
Has Abstractpub_date
2017-07-06 00:00:00pages
24issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-017-0265-xjournal_volume
22pub_type
杂志文章abstract：BACKGROUND:Prostate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-36
更新日期：2013-10-03 00:00:00
abstract：:Tooth-colored resin-based restoration materials have gained enormous significance in recent decades. Since the composites presently available still evidence various weaknesses, intensive research continues concerning them. In this study we tested the biocompatibility of six resin-based materials (Charisma, Solitaire, ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-04-27 00:00:00
abstract：BACKGROUND:In pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC-CPR). The proper performance of the procedure is a survival pr...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0369-6
更新日期：2019-02-08 00:00:00
abstract：BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0195-z
更新日期：2016-01-09 00:00:00
abstract：:In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. But, in contrast to oral and intravenous administration drug delivery to the lungs is controlled by additional par...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-14-s4-71
更新日期：2009-12-07 00:00:00
abstract：:Oxytocin is one of the most potent uterotonic agents and is known to fluctuate throughout the menstrual cycle, showing an increase during sexual stimulation and arousal, with a peak during orgasm in women. To date, limited data are available on the effects of oxytocin on the regulation of uterine contractility and tra...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-04-28 00:00:00
abstract：:In this study a potential influence of diatomaceus earth to lower blood cholesterol was investigated. During 12 weeks we monitored serum lipid concentrations in 19 healthy individuals with a history of moderate hypercholesterinemia (9 females, 10 males, aged 35 - 67 years). Individuals administered orally 250 mg diato...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-04-08 00:00:00
abstract：:Coronary angiograms performed at the time of an acute coronary syndrome typically present vessel occlusions, ruptured plaques or thrombotic lesions that require reperfusion therapy. However, occasionally, no coronary artery stenoses are detected. Myocardial ischemia frequently causes left ventricular wall motion abnor...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-08-18 00:00:00
abstract：BACKGROUND:Dopamine agonists (DA) are the first-choice drug for treatment of the early stage of Parkinson's disease (PD) in subjects younger than 70 years. Recently, a number of third generation DA have been marketed, including transdermal patch of rotigotine and extended release oral formulation of ropinirole and pram...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-60
更新日期：2013-12-21 00:00:00
abstract：OBJECTIVE:The aim of this study was to examine the influence of immuno modulating agents like bromelain and trypsin (e.g. Wobenzym on granulocyte and monocyte functions in healthy volunteers and patients with disorders of the humoral immuno system X-linked agammaglobulinaemia (XLA) and common variable immuno deficiency...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-05-29 00:00:00
abstract：BACKGROUND:It is hitherto still questionable which of the physical properties of the bile fluid influence the outcome of extracorporeal shock wave lithotripsy (ESWL). METHODS:In this study the influence of the density and viscosity of bile simulating fluid on ESWL was tested in vitro by applying CsCl solutions of dens...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-01-19 00:00:00
abstract：:In the absence of thromboprophylaxis, venous thromboembolism (VTE) affects about 50 to 80% of the patients after total hip replacement (THR), total knee replacement (TKR), or hip fracture surgery. Since stratification of patients in those who will become symptomatic and those who will not, is not possible, primary hig...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-30 00:00:00
abstract：:A fifty-year-old female presented with a one month history of progressive dyspnea, productive cough, pain of elbows and knees, and 40°C fever despite antibiotic treatment. She has been diagnosed of bronchial asthma over 25 years before admission and oral and depot glucocorticosteroids as a long-term therapy was applie...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-92
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE:The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-as...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-s4-268
更新日期：2009-12-07 00:00:00
abstract：:In 1973 copper-associated liver disease was first described in an Australian boy of non-Indian origin who died at the age of 15 months with liver cirrhosis. At necropsy the hepatic copper concentration was excessively high (> 300 mg/g dry weight). It was shown that the boy s disease was caused by consumption of copper...
journal_title：European journal of medical research
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-06-28 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. It is believed that its soluble form (sICAM-1) might be a serum parameter of inflammatory activity with possible relevance in granulomatous disorders. To evaluate this role we measured sICAM-1 by ELISA in serum and shedding of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-06-17 00:00:00
abstract：:A 65-year old woman with known history of reactive depression and failed suicide attempts ingested 7 mg digitoxin at 09.00 h. After vomiting 4 hours later, she reported the drug intake to her husband who thereupon summoned a physician. Arriving at 16.00 h, the physician was informed about the suicide attempt, but fail...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-11-25 00:00:00
abstract：BACKGROUND:Cardiovascular autonomic neuropathy (CAN) is rapidly growing in all populations worldwide. Baroreflex sensitivity (BRS) is easily applied as a diagnostic test to a large number of individuals in the general population. However, no study has reported the normal reference values of BRS for the CAN diagnostic t...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-19-8
更新日期：2014-02-12 00:00:00
abstract：OBJECTIVE:Identification of specific origin of lipid accumulation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) is the most important step in preventing this condition. Because liver steatosis, in the obese patients without any systemic disease, can be graded easily by ultrasonography (US), we...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-02-26 00:00:00
abstract：BACKGROUND:Patients with congenital absence of the portal vein (CAPV) often suffer from additional medical complications such as hepatic tumors and cardiac malformations. CASE PRESENTATION:Congenital absence of the portal vein (CAPV) is a rare malformation. We present a case of a 16-year-old Chinese girl with CAPV wit...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-014-0063-7
更新日期：2014-11-26 00:00:00
abstract：:Acute liver failure represents one of the most challenging conditions in intensive care treatment. In most cases there is no causal medical therapy available for survive making the intensive care treatment as the most important management tool, as bridge to transplant or still the recovery of the liver! These patients...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-28 00:00:00
abstract：BACKGROUND/OBJECTIVE:The continuous interaction of blood with artificial contact surfaces under cardiopulmonary bypass can lead to a substantial damage of blood cells and plasma factors. Surface biopolymers in oxygenation systems can help increasing the hemocompatibility, often combined with anticoagulative agents such...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
abstract：:The shared care paradigm is the current response to the crisis of industrial countries' health systems. The underlying information systems have to meet the shared care paradigm of communication and co-operation between all the partners involved in. This communication and co-operation must be provided in a secure way. ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-08-18 00:00:00
abstract：BACKGROUND:The expression of heparanase (HPSE) was associated with postoperative metastatic recurrence in patients with hepatocellular carcinoma (HCC). The six E-box binding sites in the core promoter of the HPSE gene suggested that transcription factors of E-box such as upstream stimulatory factor (USF) might regulate...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0045-9
更新日期：2014-08-23 00:00:00
abstract：BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0300-y
更新日期：2018-01-08 00:00:00
abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-06-30 00:00:00
abstract：:Gadolinium chelates are widely used in magnetic resonance imaging as contrast medium in patients with nephropathy. However, only few studies have investigated the effect of gadolinium on serum creatinine concentration and estimated GFR as surrogate markers of renal function. This study was performed to evaluate the ef...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-04-20 00:00:00
abstract：PURPOSE:Evaluation of MR-guided interstitial laser thermotherapy (ILT) of colorectal liver metastases under consideration of efficacy, safety and patient survival. MATERIALS AND METHODS:Sixty-six inoperable patients with a total of 117 colorectal liver metastases were treated with MR-guided laser therapy in 96 session...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-04-26 00:00:00
abstract：:Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART, ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
abstract：OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/2047-783x-14-4-171
更新日期：2009-04-16 00:00:00
