Abstract：
OBJECTIVE:It has recently been described that circulatory and BAL regulatory T-cells (Tregs), defined as CD4+CD25highCD127low are increased in patients with active sarcoidosis compared with other interstitial lung diseases. MATERIAL AND METHODS:We studied prospectively 17 patients (10 women, 7 men) of median age 39 years (range 27-65) with active granulomatous lung diseases (GLD) (10 patients with sarcoidosis (BBS), and 7 with hypersensitivity pneumonitis (HP), and 9 healthy controls. Bronchoalveolar lavage fluid (BAL) and induced sputum Treg counts, CD4+, CD8+, CD25+ cells were quantified by flow cytometry. Disease activity was measured by ACE serum level. Pulmonary function tests were performed using an Elite DL Medgraphics body box. RESULTS:We found Treg cells count significantly elevated in induced sputum from active GLD (38.3% vs. 7.1% and 5.3% in BBS, HP, and control, respectively). A significantly higher percentage of Treg cells characterized BAL cells from HP patients (2.27%; 9.5%; 2.1%, in BBS, HP and control, respectively). There was a strong correlation with ACE serum level and Treg cell count in BAL fluid of BBS patients, with no such correlation within HP patient group, nor Treg cell count and pulmonary function tests. CONCLUSIONS:Our data suggest a potential role of CD4+CD25highCD127low induced sputum and BAL lymphocytes from patients with active granulomatous lung diseases and hypersensitivity pneumonitis. An increased number of Treg cells in active GLD may be involved in immune regulation in active granulomatous lung diseases. The results indicate that analysis of these cells could be useful as markers of disease activity in granulomatous lung diseases.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Mroz RM,Korniluk M,Stasiak-Barmuta A,Ossolinska M,Chyczewska Edoi
10.1186/2047-783x-14-s4-165subject
Has Abstractpub_date
2009-12-07 00:00:00pages
165-9eissn
0949-2321issn
2047-783Xjournal_volume
14 Suppl 4pub_type
杂志文章abstract：:Experiments in space have shown that T lymphocyte function is altered in more than 50% of space crew members. There is strong evidence that such effect is due to stress rather than to weightlessness per se. However the health of astronauts was never threatened so far. Experiments in-vitro with cultures of human periph...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-09-09 00:00:00
abstract：BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-04-30 00:00:00
abstract：:Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms. A long, fully ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-15-s2-50
更新日期：2010-11-04 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. It is believed that its soluble form (sICAM-1) might be a serum parameter of inflammatory activity with possible relevance in granulomatous disorders. To evaluate this role we measured sICAM-1 by ELISA in serum and shedding of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-06-17 00:00:00
abstract：PURPOSE:Evaluation of MR-guided interstitial laser thermotherapy (ILT) of colorectal liver metastases under consideration of efficacy, safety and patient survival. MATERIALS AND METHODS:Sixty-six inoperable patients with a total of 117 colorectal liver metastases were treated with MR-guided laser therapy in 96 session...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-04-26 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio grou...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0285-6
更新日期：2017-10-18 00:00:00
abstract：:Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART, ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：BACKGROUND:Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-β/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-β on osteoclastogenesis has been detected and STAT1/2 has been shown to i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0074-4
更新日期：2015-01-07 00:00:00
abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are sporadic, acute worsening of symptoms. Identifying predictors of exacerbation frequency may facilitate medical interventions that reduce exacerbation frequency and severity. The objective of this study was to determine predictors of exacerbati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-19-18
更新日期：2014-04-08 00:00:00
abstract：BACKGROUND:Electroacupuncture is well known for its advantageous neuroanalgesic and therapeutic effects on myocardial ischemia-reperfusion injury. The purpose of the present research was to verify whether electroacupuncture can alleviate bupivacaine-induced myocardial injury. METHODS:Specific pathogen-free Wistar rats...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-020-00431-4
更新日期：2020-08-01 00:00:00
abstract：:Right ventricle (RV) dysfunction is a key outcome determinant and a leading cause of death for patients with chronic thromboembolic pulmonary hypertension (CTEPH). In this report, we followed the 5-year clinical journey of a patient with CTEPH. The tricuspid pressure gradient was significantly increased in the early p...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0112-x
更新日期：2015-03-02 00:00:00
abstract：:To investigate Candida epidemiology and immunologic correlates of protection in HIV-1 infected patients, we analyzed oral Candida colonization in correlation to the Candida-specific T-cell response measured by g-IFN ELISPOT using different Candida (C.) albicans strains. In 16/46 patients (13 asymptomatic, 3 with oral ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-11-30 00:00:00
abstract：:Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agent...
journal_title：European journal of medical research
pub_type： 总体
doi：
更新日期：2000-11-30 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the association between leisure-time physical activity (LPA) and the risk of metabolic syndrome (MS). METHODS:Prospective cohort studies of the association between LPA and the risk of MS were retrieved from the PubMed and Embase databases up to 12 August 2013. The sta...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1186/2047-783X-19-22
更新日期：2014-04-23 00:00:00
abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T-cell-dependent B-cell activation and altered T-cell response. Co-stimulatory and co-inhibitory molecules regulate and exert T-cell differentiation, survival and cytokine production. CD134+ and PD-1+ T-cells in SLE patients are inc...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0385-6
更新日期：2019-07-22 00:00:00
abstract：:Soluble cell adhesion molecules such as sICAM-1 in serum and other biological fluids are suggested as being useful diagnostic parameters for a variety of diseases. Since increased concentrations during diseases are frequently less pronounced compared to other parameters, we tested whether it would be necessary to alig...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
abstract：PURPOSE:In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compa...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0265-x
更新日期：2017-07-06 00:00:00
abstract：OBJECTIVE:B7-H4, a member of the B7 family of immunoregulatory receptors, may participate in the negative regulation of cell-mediated immunity. Aberrant B7-H4 expression is detected in some tumors and it plays a role in the occurrence and development of tumors. The aim of this study was to elucidate the functional and ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-7-295
更新日期：2011-07-25 00:00:00
abstract：OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-08-16 00:00:00
abstract：BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-01-28 00:00:00
abstract：:The Gasperini syndrome is a very rare brainstem disease characterized by the typical combination of ipsilateral lesions of the cranial nerves V-VII and dissociated contralateral hemihypesthesia, whereas both contralateral and ipsilateral hypacusis was described. Since the first description in 1912, only a few cases of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-9-413
更新日期：2009-09-01 00:00:00
abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-10-22 00:00:00
abstract：:Invasive aspergillosis and disseminated candidiasis are the two major manifestations of opportunistic invasive mycoses. Their incidence has risen considerably during the past decades, due to more intensive anticancer chemotherapy, organ transplantations, intensive care, and aggressive surgical interventions. Especiall...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-31 00:00:00
abstract：:The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-1-42
更新日期：2009-01-28 00:00:00
abstract：:The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-3-106
更新日期：2009-03-17 00:00:00
abstract：BACKGROUND:A great variety of dental materials are now available for use in restorative treatments. Much attention has been devoted to physical and chemical properties, but the biological effects of these materials have been less frequently studied. AIM:The aim of this study is to test the influence of resin based res...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-10-29 00:00:00
abstract：:Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer sur...
journal_title：European journal of medical research
pub_type： 社论
doi：10.1186/s40001-018-0359-0
更新日期：2019-01-03 00:00:00
abstract：:Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-09-28 00:00:00
abstract：:Fluid shift after entering into microgravity, but also under equivalent flight conditions leads to enormous increase of intraocular pressure. To assess this precisely position - and gravity independent, handsome, automatic tonometers have been developed (German-Spacelab D1-Mission, German-Spacelab D2-Mission, German-R...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-01-26 00:00:00
