Abstract:
:A decline in our ability to successfully treat patients with malaria infections of the parasitic protozoan Plasmodium falciparum with cheap quinoline drugs has led to a huge escalation in morbidity and mortality in recent years. Many approaches have been taken, including classical genetics, reverse genetics and molecular epidemiology, to identify the molecular determinants underlying this resistance. The contribution of the P. falciparum multidrug resistance gene, pfmdr1, to antimalarial resistance has been a source of controversy for over a decade since it was first identified. In the current issue of Molecular Microbiology, Sidhu and colleagues use powerful reverse genetics to demonstrate the importance of commonly occurring alleles of pfmdr1 in conferring resistance to the second-line drugs quinine and sensitivity to the new alternatives mefloquine and artemisinin. They also elegantly highlight the importance of genetic background and epistasis between pfmdr1 and other potential modulators of drug resistance. Such molecular knowledge will facilitate surveillance/monitoring and aid the development of strategies for the reversal of resistance.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Duraisingh MT,Refour Pdoi
10.1111/j.1365-2958.2005.04748.xsubject
Has Abstractpub_date
2005-08-01 00:00:00pages
874-7issue
4eissn
0950-382Xissn
1365-2958pii
MMI4748journal_volume
57pub_type
评论,杂志文章,评审abstract::In the yeast Saccharomyces cerevisiae, PKA and Sch9 exert similar physiological roles in response to nutrient availability. However, their functional redundancy complicates to distinguish properly the target genes for both kinases. In this article, we analysed different phenotypic read-outs. The data unequivocally sho...
journal_title:Molecular microbiology
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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更新日期:2010-07-01 00:00:00
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