Abstract：
AIMS:The aim of this study was to determine whether the introduction of generic formulations of antiepileptic drugs (AED) would lead to an economic saving for the public health service. DEVELOPMENT:The narrow therapeutic index, low solubility and non-linear pharmacokinetics of some AED mean that the ranges of bioequivalence that are authorised for generic formulations do not offer the same results regarding effectiveness and safety as those obtained by brand name drugs. This is why the potential saving stemming from the use of generic AED may be exceeded by the costs deriving from the consequences conditioned by their utilisation. These are the conclusions that can be drawn from the results of cost and effectiveness analyses conducted on two hypothetical cases of substituting (9 and 20%) treatments involving brand name carbamazepine (CBZ) with generic formulations. If a generic CBZ were introduced into the treatment of 9% of the patients taking this drug, the annual cost for one person with epilepsy would rise by 38.17 as compared to treating all these patients with brand name CBZ (marginal cost-effectiveness), and overall spending on health care in the country would grow by 2,748,000 (cost-benefit analysis). These figures rise sharply when 20% of treatments with brand name CBZ are replaced by generic formulations. CONCLUSIONS:The bioequivalence ranges authorised for generic formulations may be inappropriate for generic AED. With certain AED, replacing a brand name product with a generic version of the same medication can have negative effects on the amount of health care resources that are consumed and, therefore, on the overall economic expenditure associated with epilepsy.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Argumosa A,Herranz JLsubject
Has Abstractpub_date
2005-07-01 00:00:00pages
45-9issue
1eissn
0210-0010issn
1576-6578pii
rn2005233journal_volume
41pub_type
杂志文章abstract：INTRODUCTION:Non-verbal learning disorder (NVLD) is the name given to a complex group of difficulties with a well-defined biological substrate. Their clinical manifestations affect the motor area, visuospatial organisation and the social competencies. AIM:To analyse the semiology that differentially identifies NVLD by...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-27 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
abstract：INTRODUCTION:Recent studies suggest that furosemide (FUR), a chloride cotransporting antagonist, acts directly on neurons of central nervous system modifying the ionic flow. OBJECTIVE:The aim of the present study was to determine the extrarenal antiedema effect of FUR. MATERIAL AND METHODS:Male Sprague-Dawley rats we...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：INTRODUCTION:Hyperglycemia increases morbimortality in cerebral infarcts. In animal models, this relationship is only seen during the initial moments of cerebral ischaemia. The time needed in humans for cerebral damage to occur due to hyperglycemia is not known. MATERIAL AND METHODS:We included 194 patients admitted w...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：INTRODUCTION:Cockayne syndrome (CS) is a rare autosomal recessive disease which is characterized by physical and mental retardation, progressive neurological disfunction, photosensitivity and other cutaneous features. Usually they present ophthalmologic abnormalities as well as other heterogenous clinical, radiological...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-16 00:00:00
abstract：AIM:To describe clinical results and complications derived from vagal nerve stimulation therapy in drug resistant epileptic patients unsuitable for other surgical treatments, since the first implant in an epilepsy national referral centre. PATIENTS AND METHODS:A retrospective analysis of the patients implanted in our ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:There is currently a growing interest for conducting studies into the electrical and neurochemical activity of the pedunculopontine nucleus (PPN) due to the privileged position occupied by this structure in the flow of information to and from the cortex. This nucleus acts as a relay, not only for the motor...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-16 00:00:00
abstract：:In embryonic mesencephalic transplant in patients with Parkinson s disease dopaminergic survival is low (5 10%), and for this reason the use of multiple donors has been considered. The difficulty of obtaining more tissue determines the need for a procedure that enables human nigral tissue to be stored for a time witho...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:The endocannabinoid system consists of cannabinoid receptors, endogenous ligands and the enzymatic elements involved in their synthesis and breakdown. AIM:To report on currently held knowledge about the functioning of the system as a modulator of the neuroinflammatory processes associated with chronic dis...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:In all cases of young persons with clinical Parkinson s disease it should be suspected that it is secondary to some primary disorder. Therefore a battery of diagnostic tests should be done before classification as idiopathic Parkinson s disease. CLINICAL CASE:A 31 year old woman whose only previous illnes...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：INTRODUCTION:Functional hemispherectomy consists in palliative epilepsy surgical procedure usually performed in patients with pharmaco-resistant epilepsy and hemispheric syndromes. It is based on the neural disconnection of the affected hemisphere with preservation of the vascular supply. AIM:To analyze long-term prog...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：TITLE:Aneurisma traumatico de la arteria meningea media en el contexto de un hematoma epidural. : ...
journal_title：Revista de neurologia
pub_type：
doi：10.33588/rn.6904.2019145
更新日期：2019-08-16 00:00:00
abstract：INTRODUCTION:Genetic etiology in suggested in intracranial aneurysms. Such hypothesis is supported on familial aggregation, ocurrence in identical twins or associated to genetic diseases like adult polycystic renal disease. OBJECTIVE:To identify biological features in familial aneurysms different to sporadic ones. PA...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：INTRODUCTION:Hypertrophic pachymeningitis is an infrequent disease that is characterised by inflammatory hypertrophy of the dura mater. There are cranial, spinal and craniospinal forms of the disease. They may be due to underlying infectious, autoimmune or neoplastic processes, although most of the cases reported in re...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-16 00:00:00
abstract：INTRODUCTION:Strachan's disease is a condition which mainly affects the nervous system. It is characterized by optic, auditory and peripheral neuropathies and lesions of the skin and mucous membranes. In 1955 Miller Fisher gave it this name, since the clinical condition described by Henry Strachan in Jamaica during the...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：AIMS:The purpose of this study is to collect and evaluate the experimental evidence suggesting that acetaldehyde, the first oxidative metabolite of ethyl alcohol (ethanol), plays a mediating role in the brain damage associated with the chronic consumption of this substance. DEVELOPMENT:Although the brain damage associ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：INTRODUCTION:Critical illness patients may show marked weakness acquired in the Intensive Care Unit (ICU). There are some disagreements about the myopathic versus neuropathic damage in this condition, presumably due to the lack of reliable diagnostic criteria. AIMS:To report the neurophysiological findings in critical...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2010-06-16 00:00:00
abstract：INTRODUCTION:«Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinica...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:The hyperperfusion syndrome (HS) is described as an infrequent complication of carotid endarterectomy. It may also occur in percutaneous transluminal carotid angioplasty with a similar causal mechanism and clinical features to those seen in HS related to carotid endarterectomy. CLINICAL CASE:We describe t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-11-16 00:00:00
abstract：:Treatment of stroke is effective when given straight away at the onset of symptoms. Our objective was to find what the present latent periods in the medical attention of stroke patients are. A study was made in 18 hospital neurology units. The time elapsed between onset of the stroke and being attended by a doctor in ...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1996-04-01 00:00:00
abstract：:The Minimental State Examination (MMSE), created in 1975 as a tool for briefly evaluating the patient's mental state, has been widely used and is the most frequently cited cognitive test on Medline, as well as being the one with the most versions in different languages (over 70). Through a review of the Medline databa...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2015-10-16 00:00:00
abstract：INTRODUCTION:The efficiency of Cambridge Cognitive Examination' (CAMCOG) is analyzed as a tool to detect dementias in epidemiological studies. PATIENTS AND METHODS:The data were obtained from subjects who enrolled the second phase on a door-to-door field epidemiological study. The tool used was the 'Cambridge Mental D...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-16 00:00:00
abstract：:Optical coherence tomography (OCT) is a non-invasive imaging technique that allows the different layers of the retina to be visualised in vivo. One of them is the so-called retinal nervous fibre layer (RNFL), which is made up of amyelinic axons from the ganglionic cells, and therefore part of the central nervous syste...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-05-01 00:00:00
abstract：INTRODUCTION:Infantile autism is a disorder that is characterised by alterations affecting reciprocal social interactions, abnormal verbal and non-verbal communication, poor imaginative activity and a restricted repertoire of activities and interests. The causes of autism remain unknown, but there are a number of diffe...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-27 00:00:00
abstract：TITLE:Parálisis súbita de la supraversión de la mirada en una niña de 9 años. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.7110.2020275
更新日期：2020-11-16 00:00:00
abstract：INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relap...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-06-16 00:00:00
abstract：INTRODUCTION:Temporal orientation is a component of most screening tests for diagnosing cognitive impairment. Correct temporal orientation involves activating both semantic information (concepts of the calendar date) and episodic information (remembering the current date). AIMS:The aim of this study was to assess the ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-16 00:00:00
abstract：INTRODUCTION:The advance in the achievement of effective therapies for multiple sclerosis (MS), the definition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be rel...
journal_title：Revista de neurologia
pub_type： 指南,杂志文章
doi：
更新日期：2012-01-16 00:00:00
abstract：AIMS:The purpose of this work was to gather the information currently available about the content of nerve growth factor (NGF) in experimental models of neurodegeneration and in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, as well as to analyse how NGF content is affected by...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-16 00:00:00
