Abstract：
INTRODUCTION:The advance in the achievement of effective therapies for multiple sclerosis (MS), the definition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be related to lack of adequacy of the preclinical studies in MS experimental animal models. AIM:To standardize the methodological protocols of experimental models by developing a set of guidelines for preclinical studies by groups of experts from REEM (Spanish Network for MS). DEVELOPMENT:A guide with recommendations for the application of MS models including a detailed assessment of appropriate experimental models taking into account the objective of the study that has been presented. Standards and quality criteria necessary in a preclinical study have been included. CONCLUSIONS:Standardized animal models of MS are essential to increase the success of the preclinical findings in order to transfer them to the clinical practice.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Moreno B,Espejo C,Mestre L,Suardiaz M,Clemente D,de Castro F,Fernández-Fernández Ó,Montalban X,Villoslada P,Guaza C,Spanish Network for MS.subject
Has Abstractpub_date
2012-01-16 00:00:00pages
114-24issue
2eissn
0210-0010issn
1576-6578pii
rn2011424journal_volume
54pub_type
指南,杂志文章abstract：INTRODUCTION:Recent studies indicate that decreased energy generation by mitochondria is a feature that is common across neurodegenerative diseases. PATIENTS AND METHODS:In order to obtain direct evidence that mitochondrial functioning is altered, we measured the hydrolytic activity of F0F1-ATPase and its capacity to ...
journal_title：Revista de neurologia
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更新日期：2005-01-16 00:00:00
abstract：INTRODUCTION:Atherosclerosis is a generalized vascular disorder which tends to be localized to specific arterial territories. At the bifurcation of the carotid artery there is a marked predisposition to form plaques of atheroma on the postero-external wall. This tendency is due to the kinematics of fluids and their par...
journal_title：Revista de neurologia
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更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:Primary angiitis of the central nervous system (CNS) is a rare disease. Clinical signs and symptoms include headache and cognitive disorders associated to multifocal neurological deficits. A definitive diagnosis can only be achieved by means of a cerebromeningeal biopsy. CASE REPORT:We describe the case o...
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更新日期：2007-02-16 00:00:00
abstract：INTRODUCTION:We analysed the characteristics, progression and outcomes observed following the embolisation of 100 intracranial arteriovenous malformations (AVM) that were performed in order to achieve complete obliteration of the AVM, the elimination of associated vascular risk factors and also to reduce their size wit...
journal_title：Revista de neurologia
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更新日期：2006-01-01 00:00:00
abstract：:The modern history of the treatment of multiple sclerosis is reflected during the last years with the advent of controlled clinical trials design to produce measurable outcomes utilizing MRI techniques and statistical analysis. Addressing in this form the use of disease modifying medications: immunomodulation with int...
journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical, electro-encephalographic and evolutionary characteristics of a series of patients diagnosed as having benign neonatal sleep myoclonus (BNSM). MATERIAL AND METHODS:The clinical histories of 21 patients with BNSM were analyzed. Criteria for inclusion in the study were: neonates who ha...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-05-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
abstract：:The diagnostic criteria for the attention deficit/hyperactivity disorder (ADHD) were defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders, fourth version. ADHD is a neuro-psychiatric disorder associated with impairments in everyday life and behavioral dysregulati...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2019-06-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:Glutaric aciduria type I is an autosomal recessive inborn error of metabolism that is due to a deficiency of the enzyme glutaryl-CoA dehydrogenase, which gives rise to an accumulation of glutaric and 3-hydroxyglutaric acids in biological fluids. Clinical features present as a sudden-onset severe neurologic...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-05-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-08-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-02-16 00:00:00
abstract：INTRODUCTION:Alzheimer's disease is 1.5 to 3 times more frequent in women than in men. This fact can be biased as women as a group have more long life survival. Semantic memory and naming are more frequently and severely impaired in women. DEVELOPMENT:Both genetic and environmental factors can contribute when one dete...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-06-16 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
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更新日期：2003-09-01 00:00:00
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doi：
更新日期：2018-01-01 00:00:00
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更新日期：2006-02-16 00:00:00
abstract：INTRODUCTION:Clinical, electrophysiological, genetic and biochemical deficiencies variability were evaluated in 52 patients diagnosed of mitochondrial respiratory chain diseases (MRCD). PATIENTS AND METHODS:26 men and 26 women, aged 19 to 79 years, were tested by clinical examination, electrophysiological techniques, ...
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更新日期：2005-10-16 00:00:00
abstract：TITLE:42.ª Reunion de la Sociedad de Neurofisiologia Clinica de las Comunidades de Valencia y Murcia. Comunicaciones. : ...
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更新日期：2017-12-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：1998-04-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2007-03-16 00:00:00
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journal_title：Revista de neurologia
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更新日期：1997-08-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-16 00:00:00
