Abstract：
AIMS:In the search for new, potentially treatable, vascular risk factors, one of the most recent to be put forward is the presence of increased total homocysteine (tHc) levels in blood plasma and this has also given rise to a large amount of literature and controversy. The origin of this hypothesis lies in the observation that patients with congenital disorders affecting homocysteine (Hc) metabolism suffered from early atherosclerosis. In this paper we analyse the studies that have been published about Hc and cerebrovascular disease (CVD). DEVELOPMENT:An important number of retrospective case control studies have found a strong dose dependent link between levels of Hc in plasma and cerebrovascular, heart and peripheral thromboembolic disease. Yet the prospective studies that have been published to date note only a weak or inexistent link between homocysteine and CVD. Moreover, some observations question the causal relationship between hyperhomocysteinemia and atherothrombosis and account for the findings in the retrospective studies as being a result of the rise in Hc following a stroke or its increasing because of classical vascular risk factors. In any case, knowing that the ingestion of folic acid, vitamin B12 and pyridoxine lowers tHc levels in plasma has led to clinical trails being set up that evaluate the effects of this treatment on vascular risk. CONCLUSION:The relation between Hc levels in plasma and CVD is open to controversy. New studies and the findings of clinical studies with vitamin therapy will allow this relation to be fully explained in coming years.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Sepúlveda-Sánchez JM,Matía-Francés R,Martínez-Salio A,González-de la Aleja-Tejera J,Rodríguez-Peña Marín M,Porta-Etessam Jsubject
Has Abstractpub_date
2004-02-16 00:00:00pages
347-58issue
4eissn
0210-0010issn
1576-6578pii
rn2003605journal_volume
38pub_type
杂志文章,评审abstract：INTRODUCTION:Mental retardation (MR) is a clinical condition that may be due to a large variety of causes, the most important of which are those of a genetic origin, owing to the repercussions they can have on the family. There are more than one thousand types of MR with a genetic origin, and they are not usually found...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-07 00:00:00
abstract：OBJECTIVE:To show the disorders of the brain cortical development and the possible origin in base to a large series studied in a Pediatric Neurology service. PATIENTS AND METHODS:A series of 144 children with ages ranging between newborn and 12 years was studied from the clinic, image (MR, 3DMR) and evolutive point of...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-16 00:00:00
abstract：OBJECTIVES:The published data on neurological resources and the demand for neurological care in Spain were reviewed. Also, this demand was analysed in a specific health district (area 11, Hospital Universitario 12 de Octubre, Madrid). DEVELOPMENT:About 2.5 neurologists per 100,000 inhabitants in Spain was estimated to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：INTRODUCTION:Studies on focal dystonia showed that the formulations of botulinum toxin type A, incobotulinumtoxin-A (Inco-BTA) and onabotulinumtoxin-A (Ona-BTA), have equivalent efficacy and safety. AIM:To carry-out a cost-utility analysis of Inco-BTA administered on flexible intervals vs. Ona-BTA on a fixed interval,...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-12-16 00:00:00
abstract：INTRODUCTION:Meningioma is the most common primary intracranial tumor, accounting for around a third of all primary brain tumor. In most cases, they are benign neoplasms that start in the cells of the arachnoid mater. Meningiomas are typically slow growing; however they can metastasize in 0.1% of all patients. CASE RE...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-02-16 00:00:00
abstract：INTRODUCTION:Adrenoleukodystrophy is a hereditary recessive sex-linked disorder with very variable phenotype expression, including classical infantil ALD, adrenomyeloneuropathy (AMN) in adults and sex-linked Addison's disease. Clinical observations. Three affected patients are presented. The first showed signs of myelo...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：INTRODUCTION:Sciatic nerve paralysis is a rare entity in the newborn. Few reference in specialized tests indicate that in the majority of cases the sciatic palsy has been observed after misplaced injections into the buttocks. The prognosis is variable and appears to be better after umbilical vessel catheterization for ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：AIM:To report a case of sub-acute encephalopathy with all the extension study negative and with response to steroid therapy. CASE REPORT:The study involves a 22-year-old female with no relevant past history who presented symptoms of sub-acute encephalopathy consisting in behavioural disorders, generalised seizures and...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To present a case with several cutaneous hemangiomas associated with intracranial hemangiomas and possibly with an intrahepatic hemangioma. CASE REPORT:A boy, 17 months old, showing several cutaneous hemangiomas and epileptic seizures resisting to antiepileptic medication, who also presented psychomotor reta...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Magnetic resonance is the most sensitive para-clinical method available for the diagnosis of multiple sclerosis since it shows changes in 95% of the patients with clinically definite multiple sclerosis. However, little correlation has been found, in different studies, between the parameters of magnetic resonance and t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-16 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
abstract：INTRODUCTION:The efficiency of Cambridge Cognitive Examination' (CAMCOG) is analyzed as a tool to detect dementias in epidemiological studies. PATIENTS AND METHODS:The data were obtained from subjects who enrolled the second phase on a door-to-door field epidemiological study. The tool used was the 'Cambridge Mental D...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-16 00:00:00
abstract：INTRODUCTION:People with a fibromyalgia diagnosis complain of having very poor cognitive functioning. In recent years, there has been an increasing interest to investigate which cognitive impairment is present in this disease. AIM:To review the published research on fibromyalgia and cognitive dysfunction. DEVELOPMENT...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT:Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-16 00:00:00
abstract：INTRODUCTION:The new antiepileptic drugs should also be evaluated outside clinical trials. OBJECTIVE:To study the efficacy of treatment with lamotrigine in everyday neuropaediatric clinical practice. PATIENTS AND METHODS:We made a longitudinal study of all patients treated with lamotrigine in a hospital outpatients d...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-07-16 00:00:00
abstract：AIM:We review three of the most important functional techniques in magnetic resonance imaging, it means spectroscopy, perfusion and diffusion; we do emphasize in its applications, particularly in the diagnostic and treatment of brain tumors. First, we discuss the physical principles and results interpretation of each t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2006-06-16 00:00:00
abstract：INTRODUCTION:Despite their importance, little attention has been given to the recognition of early markers of hyperactivity in the scientific literature and in everyday practice it can be difficult to separate some of the physiological behaviours displayed by older babies or preschool infants from pathological processe...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-13 00:00:00
abstract：INTRODUCTION:Arterial gas embolism (AGE) is a main iatrogenic complication resulting from the use of invasive procedures. It is difficult to diagnose if it is not clinically suspected. CASE REPORT:A 67-year-old male patient, with a history of interventions involving a mitral prosthesis and a double aortocoronary bypas...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：INTRODUCTION:The epidemiology of multiple sclerosis (ME) in the Alcoi area has been studied by our groups for many years. When studying the factors linked to ME in this area initially we observed that migration, contact with dogs and the textile industry were associated with the disorder. A later study, in which the mi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：INTRODUCTION:In recent years several authors have proposed that muscle pathological changes in humans with dystrophin disorders and in mdx-mice are the result of regeneration attempts of this tissue subjected to constantly repeated bouts of necrosis. AIM:We compared morphological aspects of degenerative-regenerative g...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-06-16 00:00:00
abstract：INTRODUCTION:Acute vascular lesions limited to the midbrain can yield varied disturbances of eye movements. They are more often infarcts than hemorrhages. CLINICAL CASE:We present the case of a 49 year old, non-hypertensive man who presented with sudden onset of bilateral up and down gaze palsy. CT defined a unilatera...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-02-16 00:00:00
abstract：:Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-16 00:00:00
abstract：AIMS:The main objective of this study is to describe the different neuropsychological deficits associated to the consumption of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), as well as the growing evidence that attributes these deficits to the selective axonal damage to serotoninergic cells brought about by th...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-16 00:00:00
abstract：AIMS:The purpose of this study was to establish certain epidemiological characteristics of cerebral aneurysm surgery at the Hospital Regional Docente Vicente Corral Moscoso (HVCM), in the city of Cuenca. PATIENTS AND METHODS:We examined the medical records of the patients who were treated at the HVCM, in Cuenca, over ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：INTRODUCTION:Reduced facial expression or amimia is one of the most typical characteristics of Parkinson's disease (PD). Despite being described in classic texts, its significance, physiopathology and correlation with motor and non-motor symptoms is largely unknown. PATIENTS AND METHODS:We have studied facial bradykin...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-01-16 00:00:00
abstract：OBJECTIVE:The object of this study to analyse and compare the efficacy of the classic language tasks (repetition, phonological fluency and lexical decision), for the purpose of identifying the dominant hemisphere for language by means of functional magnetic resonance. SUBJECTS AND METHODS:The three tasks were performa...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-07-16 00:00:00
abstract：INTRODUCTION:Surgery for resection of supratentorial lesions near the motor areas and/or internal capsule carries an associated risk of damage to cortical or subcortical motor pathways. Intraoperative brain mapping, using direct cortical electric stimulation, is a surgical adjunct used during lesionectomy in functional...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-06-16 00:00:00
abstract：INTRODUCTION:Cochrane Collaboration (CC) contains detailed, critical and up-to-date systematic reviews (SR) of the best scientific evidence available. AIM:To analyse the bibliometric characteristics of the SR related to paediatric neurology published in the 50 Collaborative Review Groups (CRG) of the CC. MATERIALS AN...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-16 00:00:00
abstract：OBJECTIVES:To review the mechanisms of cell death (CD) in the developing brain after hypoxia-ischemia (HI). DEVELOPMENT:The possibility of limiting the CD which occurs in serious situations of cerebral HI is based on advances in the understanding of the underlying cellular and molecular mechanisms. Various experimenta...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-16 00:00:00
abstract：INTRODUCTION:The implementation of an on-call neurology service at our hospital prompted us to analyse the health care it offers. PATIENTS AND METHODS:We conducted a retrospective descriptive study by reviewing the status report of the on-call services performed between 15 April 2002 and 14 April 2003. The data collec...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-07-16 00:00:00
