[Sub-acute encephalopathy that responds to steroids without any evidence of autoimmune thyroid disease: a case of non-vasculitic autoimmune meningoencephalitis].

Abstract:

AIM:To report a case of sub-acute encephalopathy with all the extension study negative and with response to steroid therapy. CASE REPORT:The study involves a 22-year-old female with no relevant past history who presented symptoms of sub-acute encephalopathy consisting in behavioural disorders, generalised seizures and bradypsychia, which gradually progressed to a state of low-level consciousness. While she was in hospital all kinds of diagnostic tests were conducted, the results of which were either normal or negative; the electroencephalogram was repeatedly abnormal and detection of protein 14-3-3 in cerebrospinal fluid was positive. Empirical corticoid therapy was begun with clinical and electrophysiological improvements and the patient recovered completely without any sequelae. CONCLUSIONS:With no evidence of autoimmune thyroid disease, although non-specific autoimmunity was present, the patient was diagnosed as having non-vasculitic autoimmune meningoencephalitis.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

López-Ariztegui N,Lobato-Casado P,Muñoz-Escudero F,Polo-Martín M,Montes-Gonzalo MC,Alvarez-Tejerina A

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

359-62

issue

7

eissn

0210-0010

issn

1576-6578

pii

rn2009211

journal_volume

49

pub_type

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