Abstract：
OBJECTIVES:To review the mechanisms of cell death (CD) in the developing brain after hypoxia-ischemia (HI). DEVELOPMENT:The possibility of limiting the CD which occurs in serious situations of cerebral HI is based on advances in the understanding of the underlying cellular and molecular mechanisms. Various experimental models offer the opportunity to study these mechanisms in reproducible situations. Relevant concepts are the focal HI as compared to global HI, with well-differentiated patterns of selective vulnerability which depend on vascular and neurochemical factors. In situations of infarct, the distinction between core and penumbra permits the identification of areas of brain tissue which potentially may recover, where the CD occurs, at least partially, more slowly and by apoptosis. Most of this CD occurs during the phase of reperfusion, when the reintroduction of oxygen activates the neurotoxic cascades. Amongst the molecules involved in the early marking of cell damage are the genes c-fos and c-jun, HSP, MAP-2, cytokines, GLUT3 and calpaines. Some of the recent attempts of block post-HI MC are treatments with trophic factors, glucocorticoids and hypothermia. CONCLUSIONS:Analysis of the time-course of MC in perinatal HI suggest the presence of a therapeutic window. The development of treatments for nerve rescue comes up against the complexity of the mechanisms involved in MC and their potential toxicity in immature brain.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Macaya Asubject
Has Abstractpub_date
2000-10-16 00:00:00pages
784-9issue
8eissn
0210-0010issn
1576-6578journal_volume
31pub_type
杂志文章,评审abstract：INTRODUCTION:The combination of subarachnoid hemorrhage (SAH) and subhyaloid hemorrhage is known as 'Terson syndrome'. Retinal hemorrhage is commonly observed clinically in the optic fundi of patients with SAH, however, subhyaloid hemorrhage of the globe in the setting of SAH has been rarely on CT of the brain. Several...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：INTRODUCTION:Protein-energy malnutrition continues to affect millions of human beings in developing countries. Children suffer most from the shortage of nutrients because at early ages malnutrition has an important impact on the central nervous system. The changes that malnutrition triggers in the brains of these child...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-03-02 00:00:00
abstract：INTRODUCTION:Status epilepticus (SE) is a condition in which epileptic discharges are sufficiently prolonged or repeated so as to cause persistent changes in neurological function. DEVELOPMENT:At the present time the classification of SE seems to be incomplete and therefore provisional. However the broad subdivision i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-08-01 00:00:00
abstract：INTRODUCTION:A spinal cord injury implies the loss of or alteration to the gait pattern. Stimulating the pattern generating centres in the sublesional spinal cord determines the appearance of flexion and extension automatisms that are useful for gait training in patients with spinal cord injuries. These centres can be ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:To evaluate the diagnostic efficacy of an intra-arterial electroencephalographic recording and determine which patients obtain most benefit from this technique, to compare the results obtained using other recording techniques and to establish a standard for recording. PATIENTS AND METHODS:We made 64 intra-a...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：AIM:To analyse the data and concepts that have been produced in relation to one of the functions that have been suggested for sleep, namely, neuronal recovery. DEVELOPMENT:Sleep is a state of consciousness that is different to that of arousal. Mammals devote an important part of their lives to sleeping; for example, a...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
abstract：INTRODUCTION:Nonconvulsive status epilepticus (NCSE) of frontal origin is a form of partial status epilepticus which has rarely been well-documented. The inespecificity of the symptoms contribute frequently to its misinterpretation being the EEG the most useful tool to make an accurate diagnosis. CLINICAL CASE:We repo...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：TITLE:Analisis bibliometrico de las investigaciones españolas sobre neurorrehabilitacion en el ictus indizadas en Medline (2008-2017). : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.6811.2019070
更新日期：2019-06-01 00:00:00
abstract：:In the last years there is an increasing interest in the knowledge of vascular status in patients with acute stroke. Detection and localization of an artery occlusion is of great interest for an accurate prognosis and the selection of the most appropriate recanalizing therapy. Neurosonology is a useful diagnostic tool...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION AND MATERIAL:Nine brains belonging to early onset Alzheimer disease (E280A-PS1 mutation) affected individuals from Antioquia, Colombia, were analyzed by neuropathological standard techniques. All individuals were ascertained from genealogies descendents from a common ancestor that shows a dominant autosomi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relap...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-06-16 00:00:00
abstract：INTRODUCTION:Diabetes and dementia are growing problems throughout the world and especially in developing countries. AIM:To determine the risk of developing dementia in subjects with type 2 diabetes mellitus. PATIENTS AND METHODS:Diabetic elders free of dementia from the Mexican Health and Aging study, a prospective ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:In the early stages of their development, children acquire the skills and knowledge that provide them with the foundations on which they will later add what they learn at school, including skills such as reading, writing and mathematics. The presence of learning difficulties at the infantile stage can affe...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-13 00:00:00
abstract：INTRODUCTION:Almost three out of every four people in the world who suffer a fatal stroke live in developing countries. A number of different tropical diseases may appear in Europe in the coming years as a consequence of the demographic change that is being brought about by migratory flows. We review the main infectiou...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-16 00:00:00
abstract：INTRODUCTION:Throughout the history of thought, science and philosophy have addressed the problem of mind-brain from different epistemic perspectives. The first covers specific areas of reality and constructs hypotheses with limited scope and multiple inter-scientific connectivity with the aim of validating theoretical...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To carry out a bibliographic review of articles indexed in MEDLINE over the past 20 years concerning the pharmacological treatment of agitation in head injury. DEVELOPMENT:Head injury may cause different behaviour changes, of which agitation is the most dramatic. The incidence of agitation after severe head ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：INTRODUCTION:Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units. AIM:To evalu...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-10-16 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
abstract：OBJECTIVE:To present a new formulation of human death based on neurological considerations. DEVELOPMENT:One of the reasons there is still controversy over a new formulation of human death which is acceptable to society, is that many authors do not suitably integrate three fundamental aspects which should be included i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:Restless legs is an unpleasant sensation in the calves that occurs when the individual is sitting or laying down, with an irresistible urge to move the legs. It has been know as a cause of insomnia. We have been using various drugs with a variety of effectiveness. Levodopa is now considered the drug of cho...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-05-16 00:00:00
abstract：INTRODUCTION:Unilateral or bilateral agenesis of the internal carotid artery has not often been described in children since it is usually asymptomatic. CLINICAL CASE:We describe a case of isolated unilateral agenesis of the internal carotid artery in a child of 20 months old who presented with two episodes of status c...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：AIM:To contribute to the knowledge of the cognitive differences existent between right-handed and left-handed evaluating the cognitive outcome in a group of adults right-handed and another group of left-handed of similar characteristic (age, gender, cultural level) by means of the Wechsler Adult Intelligence Scale (WAI...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2006-01-16 00:00:00
abstract：INTRODUCTION:It may be difficult to determine the adequate mement, the information content and the most convenient person to inform patients with chronic, incurable disorders with uncertain prognosis as sclerosis multiple (MS). MATERIAL AND METHODS:To gain information on how these aspects had been carried-out and the ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:X-linked adrenoleukodystrophy is the prototype of the disorders that involve a single peroxisomal protein, and it is by far the most common peroxisomal disorder. The gene that is defective in this disorder is a peroxisomal membrane protein involved, in an as yet undefined manner, in the degradation of very long chain ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical, electro-encephalographic and evolutionary characteristics of a series of patients diagnosed as having benign neonatal sleep myoclonus (BNSM). MATERIAL AND METHODS:The clinical histories of 21 patients with BNSM were analyzed. Criteria for inclusion in the study were: neonates who ha...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-06-16 00:00:00
abstract：PATIENTS AND METHODS:Fifty patients diagnosed as having epileptic crises were given neuropsychological tests including the Wechsler Adult Intelligence Scale or WAIS, Luria's neuropsychological test and a quantitative EEG examination. Multivariate analysis was done of the following variables: presence or absence of inte...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：INTRODUCTION:In recent years Internet has drastically transformed the world of telecommunications. Questions about whether Internet and the global communication accessibility may be considered as a fundamental aspect in the medicine of today and tomorrow have been brought up. OBJECTIVE:Discuss current and future appli...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:Necrosis of the basal ganglia (NBG) is an uncommon condition in childhood. Cases of NBG have been reported in connection with metabolic disorders, infections, degenerative conditions, intoxications, head injuries and hypoxic-ischemic encephalopathies. The commonest clinical features include alteration of c...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-05-16 00:00:00
abstract：INTRODUCTION:A good deal of evidence currently exists to show that transplanting foetal mesencephalic tissue can produce symptomatic benefits both in patients and in disease models. Nevertheless, the technical and ethical difficulties involved in obtaining enough suitable foetal cerebral tissue have been a serious obst...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-08-16 00:00:00
