Abstract：
OBJECTIVE:To present a new formulation of human death based on neurological considerations. DEVELOPMENT:One of the reasons there is still controversy over a new formulation of human death which is acceptable to society, is that many authors do not suitably integrate three fundamental aspects which should be included in such a formulation: definition, criteria and diagnostic tests. We review the physiopathological mechanisms for generation of consciousness and discuss the three fundamental criteria presented by different authors in recent decades: the whole encephalum, brainstem death and neocortical criteria. We conclude that there are major contradictions in the three criteria with regard to satisfactory integration of the elements, definition, criteria and diagnostic tests. We therefore present a new formulation of human death. DEFINITION:irreversible loss of consciousness, since this gives the essential human attributes, and is the most integrating function of the organism. CRITERIA:cortico-subcortical connections for the generation of both components of consciousness (capacity and content). DIAGNOSTIC TESTS:no waking response to stimuli (capacity), no cognitive nor affective functions (content). CONCLUSIONS:We present a new formulation of human death on a neurological basis which permits satisfactory integration of the three fundamental elements, definition, criteria and diagnostic tests, and so offers a suitable starting point from which man may start to understand death.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Machado-Curbelo Csubject
Has Abstractpub_date
1998-06-01 00:00:00pages
1040-7issue
154eissn
0210-0010issn
1576-6578journal_volume
26pub_type
杂志文章,评审abstract：OBJECTIVE:To present the first Spanish case, perhaps the first non-Canadian, with ataxia type Charlevoix-Saguenay. CLINICAL CASE:A patient with important psychomotor delay and non-progressive ataxia has been studied in our Service during the first years of life and his follow-up has been carried out until 30 years of ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：AIMS:The aim of this study was to determine whether the introduction of generic formulations of antiepileptic drugs (AED) would lead to an economic saving for the public health service. DEVELOPMENT:The narrow therapeutic index, low solubility and non-linear pharmacokinetics of some AED mean that the ranges of bioequiv...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVES:To establish the role of the age on quality of life of a group of normotensive patients, older than 65 years with vertebrobasilar ischemia, treated with nicardipine. To evaluate the influence of the Nicardipine side effects on the quality of life of these patients within general practice prescription limits....
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：INTRODUCTION:Vestibular evoked myogenic potential (VEMP) elicited by acoustic stimulation, has been proposed in the assessment of vestibulospinal pathways. AIM:To research the clinical utility of VEMP on multiple sclerosis (MS). SUBJECTS AND METHODS:Forty-four individuals were evaluated (30 normal state and 14 had MS...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-03-16 00:00:00
abstract：INTRODUCTION:Progressive supranuclear palsy is a disease that normally presents only sporadically in adults and courses in a progressive, chronic manner. It is characterised by the presence of supranuclear ophthalmoplegia, postural instability, a Parkinsonian syndrome, pseudobulbar affect, cervical dystonia and cogniti...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:The literature on clinical and physiophatologic characteristics of the spectrum of memory disorders in childhood is reviewed in this article. DEVELOPMENT:There are only a few detailed reports of permanent specific memory disorders in children. Early anoxo ischaemic bihippocampal injuries can cause a selectiv...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:Transient cognitive disorders (CD) in benign rolandic epilepsy (BRE), the most common of idiopathic partial epilepsy (IPE), may be secondary to interictal epileptiform discharges (IED). OBJECTIVES:To determine incidence and risk factors for persistent TC in students with IE before, during and after antiep...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:Sleep homeostasis occurs during prolonged wakefulness. Drowsiness and sleep pressure are its behavioral manifestations and, when sleep is allowed, there is a sleep rebound of sufficient duration and intensity to compensate for the previous deprivation. Adenosine is one of the molecules involved in sleep homeostasic re...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:Primary care professionals need useful and simple tools to detect early cognitive impairment in patients with any clinical suspicion of dementia. AIM. This critical review attempts to analyze the psychometric properties of cognitive screening tests, commonly used for screening dementia in primary care sett...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Neurotoxoplasmosis (NTX) is one of the commonest opportunist infections in patients infected by the human immunodeficiency virus. It presents with a variety of clinical features in the immunocompromised patient. PATIENTS AND METHODS:We made a horizontal retrospective descriptive study of 88 patients with ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：INTRODUCTION:Several studies have reported alterations in the cerebrospinal fluid biomarkers (Abeta-42, T-tau and P-tau proteins), both in Alzheimer's disease (AD) and in mild cognitive impairment (MCI). AIM:To perform a meta-analysis of the diagnostic yield of this technique for the prediction of patients with MCI wh...
journal_title：Revista de neurologia
pub_type： 杂志文章,meta分析
doi：
更新日期：2010-02-16 00:00:00
abstract：INTRODUCTION:We describe a series of 10 children with intracranial hypertension complicating fulminant hepatic failure submitted to intracranial pressure (ICP) monitoring for intensive care and transplantation management. PATIENTS AND METHODS:Information from pediatrics patients acute liver failure admitted to our hos...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：INTRODUCTION:The value of the P300 cognitive event-related potential in the diagnosis of Alzheimer subtype neurocognitive disorders is still incipient. Recent studies suggest that combining it with neuropsychological tests by cognitive domains would allow an objective and early characterisation of the cognitive impairm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7101.2019341
更新日期：2020-07-01 00:00:00
abstract：INTRODUCTION:Vascular pathology is considered to be uncommon, with a much lower incidence than cerebral vascular pathology. PATIENTS AND METHODS:We reviewed the clinical histories of patients with a clinical diagnosis of spinal cord infarction-ischemia attended by the Neurology Department and the Neuropaediatric secti...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-11-16 00:00:00
abstract：INTRODUCTION:Basilar migraine is a particular form of migraine with an aura in which crises of headache are accompanied by symptoms of dysfunction in the vertebro-basilar territory, including alteration of consciousness in the form of stupor or coma. CLINICAL CASES:We report four patients, three men of 14, 17 and 83 y...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：INTRODUCTION:Diabetes and dementia are growing problems throughout the world and especially in developing countries. AIM:To determine the risk of developing dementia in subjects with type 2 diabetes mellitus. PATIENTS AND METHODS:Diabetic elders free of dementia from the Mexican Health and Aging study, a prospective ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:Most patients with Parkinson's disease have cognitive and behavior disorders during the course of their illness. OBJECTIVE:In this study we consider practical aspects of the treatment of patients with Parkinson's disease who have such problems. DEVELOPMENT:Better understanding of both normal and abnormal...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-16 00:00:00
abstract：INTRODUCTION:Purely bulbar hematomas are not common (0.25%-0.50% of all intraparenchymatous hematomas), probably because of the particular characteristics of the anatomy and hemodynamics of the bulbar circulation. CLINICAL CASES:We selected 18 cases. Three of these were our own and the purely bulbar localization was c...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Impairments in language and communication are a defining feature of autism spectrum disorders. There is significant variability in linguistic abilities in autism spectrum disorders. They have difficulties with certain aspects of language such as semantics functions, syntax, prosody and phon...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-03 00:00:00
abstract：INTRODUCTION:Genetic etiology in suggested in intracranial aneurysms. Such hypothesis is supported on familial aggregation, ocurrence in identical twins or associated to genetic diseases like adult polycystic renal disease. OBJECTIVE:To identify biological features in familial aneurysms different to sporadic ones. PA...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：INTRODUCTION:Hyperglycemia increases morbimortality in cerebral infarcts. In animal models, this relationship is only seen during the initial moments of cerebral ischaemia. The time needed in humans for cerebral damage to occur due to hyperglycemia is not known. MATERIAL AND METHODS:We included 194 patients admitted w...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：AIM:To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain. PATIENTS AND METHODS:A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a fiv...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2015-05-16 00:00:00
abstract：INTRODUCTION:Akinetic mutism is considered as an alteration of the motivational state of the person, which the patient is unable to initiate verbal or motor responses voluntary, even with preserved sensorimotor and surveillance functions. CASE REPORT:A 43 year-old male involved in a cerebellum arteriovenous fistula co...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-01-16 00:00:00
abstract：:In recent years, image techniques have transformed the diagnosis in Medicine. Nevertheless, they are, by now, far from a widespread clinic and surgical use. Beyond the simple picture inspection, DICOM digital files can be explored by using image analysis/processing techniques in a better way. In practice, clinicians a...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-10-16 00:00:00
abstract：:Restoration of blood flow is necessary when treating brain ischemia. However, except in very early cases, this is insufficient to prevent the cascade of mediators of cell damage unleashed by ischemia which, on the other hand, is boosted by the deleterious effects of reperfusion. We therefore consider adequate treatmen...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：INTRODUCTION:The inmuno checkpoints inhibitors are new revolutionary treatment for many neoplastic diseases in advanced stadium. There are described several types of neurological complications induced by nivolumab: polyneuropathy, seizures, radiculitis and myasthenia gravis disease. CASE REPORT:A 65 years old man with...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：10.33588/rn.6808.2018497
更新日期：2019-04-16 00:00:00
abstract：INTRODUCTION:Developmental disorders are a common pathological condition in Neuropaediatrics and do not usually present characteristic anatomical alterations in the different neuroanatomical imaging tests that can be employed, such as computerised axial tomography or magnetic resonance (MR). Positron emission tomograph...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：PURPOSE AND SETTING:To describe the prevalence and risk factors for carotid stenosis in TIA/stroke patients with non valvular atrial fibrillation (AF) and to compare clinical and CT characteristics of TIA/stroke in AF patients with and without carotid stenosis. SUBJECTS:50 TIA/stroke patients with AF who had ultrasoun...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Atherosclerosis is a generalized vascular disorder which tends to be localized to specific arterial territories. At the bifurcation of the carotid artery there is a marked predisposition to form plaques of atheroma on the postero-external wall. This tendency is due to the kinematics of fluids and their par...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-12-01 00:00:00
