Abstract：
INTRODUCTION:Genetic etiology in suggested in intracranial aneurysms. Such hypothesis is supported on familial aggregation, ocurrence in identical twins or associated to genetic diseases like adult polycystic renal disease. OBJECTIVE:To identify biological features in familial aneurysms different to sporadic ones. PATIENTS AND METHODS:Camag ey province is one of the most ancient in Cuba. Motionless population at the beginning had its sources in Spanish and African people. It has 800,000 inhabitants. 497 patients with intracranial aneurysms were operated at Manuel Ascunce Domenech Hospital between January 1982 and August 2001. We identified 15 families with intracranial aneurysms. RESULTS:31 patients were operated on of 42 intracranial sacs at the carotid territory. There were 34% of multiplicity ant three mirror aneurysms. Three patients (9.7 %) have adult polycystic renal disease. 87 % of patients present aneurysms rupture and mortality was 32 %. This last figure was related to poor admission clinical grade. CONCLUSIONS:Frequency of familial aneurysms was 6.2% Familial aggregation, aneurysms between twins associated with genetic linked disease, early age rupture, high frequency between women, posterior communicating and middle cerebral artery bifurcation preference, mirror aneurysms and high general mortality associated to massive intracranial bleeding identified this clusters of familial aneurysms and would justify imaginological screening of high risk patients before the rupture.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Vega-Basulto SD,Montejo-Montejo J,Silva-AdAn S,Mosqueda-Betancourt Gsubject
Has Abstractpub_date
2003-02-01 00:00:00pages
218-23issue
3eissn
0210-0010issn
1576-6578pii
rn2002223journal_volume
36pub_type
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