Abstract：
AIM:To evaluate the efficiency of topiramate (TPM), an antiepileptic medication (AEM) which possesses multiple mechanisms of action and good pharmacokinetics, in the different types of childhood epilepsy and to make an appraisal of its value in migraines, bipolar disorder, eating disorders and neuropathic pain, according to studies that have been published. To do so, we have made use of an analysis of the literature, together with a multi centre study conducted in Spain and personal casuistry. METHOD:We consider the percentage of seizure free patients and of patients who responded (reduction of 50% or above in the frequency of the seizures) in childhood epilepsy, partial epilepsy, generalized tonic clonic seizures, absence seizures, tonic seizures, patients with diverse types of seizures, juvenile myoclonic epilepsy, Lennox Gastaut syndrome, falling sickness and GTCS, West s syndrome and Dravet s syndrome. With monotherapy, in partial epilepsy, between 39 and 54% of patients treated were seizure free. TPM has also proved to be efficient in experiments with animals, as a neuroprotector, and in clinical trials, in type I bipolar disorder, eating disorders, neuropathic pain and migraine. CONCLUSIONS:TPM is an AEM offering a wide therapeutic spectrum that has proved to be efficient in clinical trials, expansion phases and observational studies, as an associated drug in partial epilepsy, generalized epilepsy, Lennox Gastaut syndrome, West s syndrome and Dravet s syndrome. It has proved to be more efficient in monotherapy, in partial epilepsy, as a first line AEM. TPM has also proved to be useful in mood disorders, eating disorders, neuropathic pain and tremor in observational studies, although this efficiency has not been backed up by clinical trials. In migraine and in clinical trials TPM has shown its efficiency. Its neuroprotective effect opens up new therapeutic perspectives.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Nieto-Barrera Msubject
Has Abstractpub_date
2002-09-01 00:00:00pages
S88-95eissn
0210-0010issn
1576-6578pii
rn2002191journal_volume
35 Suppl 1pub_type
杂志文章,评审abstract：INTRODUCTION:Stroke is a recognized cause of disability among adults. However the impact that the deficits that occur after a moderate/severe stroke have on long-term disability, as well as the response of the resultant deficits to rehabilitation, are not completely understood. PATIENTS AND METHODS:A total of 396 pati...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:Epilepsy is a common disease with important social and economic repercussions. Patients with epilepsy have traditionally been discriminated by both the general population and physicians. A physician's lack of knowledge about epilepsy could be the cause of an incorrect clinical control (CC). AIMS:The purpo...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:Devic's optic neuromyelitis is an unusual condition characterized by the association of unilateral or bilateral optic neuritis and myelitis, both of which are relapsing. Prognosis is usually poor, both for the optic nerve and for the spinal medulla which becomes cavitated. This leads to severe handicap and...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：INTRODUCTION:People with a fibromyalgia diagnosis complain of having very poor cognitive functioning. In recent years, there has been an increasing interest to investigate which cognitive impairment is present in this disease. AIM:To review the published research on fibromyalgia and cognitive dysfunction. DEVELOPMENT...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:In recent years, the non-motor symptoms of Parkinson's disease, including those of a psychiatric nature, have been receiving greater attention from the scientific community. DEVELOPMENT:In this paper we analyse the pathophysiological bases underlying the different psychiatric symptoms, examining the dopam...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:The combination of subarachnoid hemorrhage (SAH) and subhyaloid hemorrhage is known as 'Terson syndrome'. Retinal hemorrhage is commonly observed clinically in the optic fundi of patients with SAH, however, subhyaloid hemorrhage of the globe in the setting of SAH has been rarely on CT of the brain. Several...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The aortic atherosclerotic debris is considered a high risk embolic source, being an independent predictor for cerebrovascular ischemia. The incidence is higher in the elderly and in patients with coronary artery disease. Transesophageal echocardiogram (TEE) is an important diagnostic tool that allows its de...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-06-16 00:00:00
abstract：AIMS:To evaluate the presence of epileptiform discharges and the organisation of nocturnal sleep of autistic children without nocturnal polysomnographic epileptic seizures. SUBJECTS AND METHODS:Cross section analysis. SUBJECTS:21 boys and girls with autistic spectrum using DSM IV criteria between the ages of 4 and 12...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
abstract：TITLE:XV Reunion Anual de la Asociacion Madrilena de Neurologia. Comunicaciones. : ...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-12-16 00:00:00
abstract：AIM:To describe clinical results and complications derived from vagal nerve stimulation therapy in drug resistant epileptic patients unsuitable for other surgical treatments, since the first implant in an epilepsy national referral centre. PATIENTS AND METHODS:A retrospective analysis of the patients implanted in our ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease that essentially affects the white matter of the central nervous system. The diagnosis is based on clinical-imaging and developmental findings. Magnetic resonance imaging of the brain is the most useful diagnostic tool. The disease cour...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：:We report a 25-year-old woman with gradual loss of visual acuteness, during puerperium and blindness in fifteen days. Two months latter she remain steady. Visual evoked potentials using monocular checkerboard pattern-reversal, were abnormal. Clinical suspicion of voluntary alteration of VEP was considered. A second VE...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
abstract：INTRODUCTION:The description of Upper Airway Resistance Syndrome (UARS) let us to recognize the importance of the pair 'respiratory effort-arousal' on sleep-disordered breathing pathophysiology. DEVELOPMENT:First part of this paper reviews knowledge about respiratory arousal pathophysiology. Arousal response is normal...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-16 00:00:00
abstract：INTRODUCTION:It may be difficult to determine the adequate mement, the information content and the most convenient person to inform patients with chronic, incurable disorders with uncertain prognosis as sclerosis multiple (MS). MATERIAL AND METHODS:To gain information on how these aspects had been carried-out and the ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：AIMS:The purpose of this study is to review different aspects of mitochondrial myopathies. DEVELOPMENT:Mitochondrial DNA is different to that found in the nucleus and is generally inherited through the mother. There are from 2 to 10 copies per mitochondrion and hundreds or thousands of mitochondria per cell. It contai...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-10-16 00:00:00
abstract：INTRODUCTION:Perforating artery disease is still the main cause of lacunar infarcts (LI), while the relationship between this type of ischemia and carotid stenosis (CS) is controversial. OBJECTIVE:To assess the association between CS and LI in patients with criteria of localized ischemia in the carotid territory separ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-16 00:00:00
abstract：INTRODUCTION:The signals obtained during conventional needle examination are usually assessed subjectively by the neurophysiologist. Buchthal's approach allows quantification of several motor unit parameters during mild effort. DEVELOPMENT:The automatic methods of analysis of the EMG interference pattern (IP), in part...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-03-16 00:00:00
abstract：INTRODUCTION:Advances in neuroimaging in the last decade have allowed a number of new findings about attention deficit hyperactivity disorder (ADHD) to be obtained. Quickly developing technology, together with the progress being made in genetics and neurochemical research, suggests a dysfunction of the fronto striatal ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-03 00:00:00
abstract：:Visuospatial impairment has been frequently reported in Parkinson's disease (PD). We present the progressive distortion performance of the Rey-Osterrieth complex figure in parkinsonian patients at different stages of the disease (PD de novo, PD on long-term treatment, PD with phychosis and PD with dementia). ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-16 00:00:00
abstract：INTRODUCTION:Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units. AIM:To evalu...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-10-16 00:00:00
abstract：INTRODUCTION:Tourette syndrome is a neurologic disorder characterized by involuntary vocal and motor tics. It affects around 1 to 2% of school-age children and is the most common movement disorder in paediatric age. Tics are involuntary or semivoluntary, sudden, brief, intermittent, repetitive movements (motor tics) or...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-23 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Reported observations of acquired aphasia in children contain all the symptoms and syndromes that have been described in adult aphasiology. Recovery of colloquial language is good even if anomia and verbal memory deficits persist as the most frequent defects. At long term outcome there are ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Epilepsy is one of the most common neurological disorders, affecting about one percent of the world population. Pharmacological treatment fails in one-third of these patients. Surgical intervention has become an accepted treatment option for those patients with seizure disorders that are refractory to conv...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION:The term idiopathic T-CD4 lymphocytopenia is used to describe a new syndrome, defined as reduced T-CD4 lymphocytes in persons with no evidence of HIV infection or other causes which would explain the immunosuppression (secondary to neoplasties, immunosuppressive treatment, hereditary immunodeficiencies, in...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-16 00:00:00
abstract：:The new insights presented at the 5th Joint Triennial Congress of the European and Americas Committees on Treatment and Research in Multiple Sclerosis (ECTRIMS and ACTRIMS) held in Amsterdam, the Netherlands, 19-22 October 2011, have been summarized at the fourth edition of Post-ECTRIMS meeting held in Madrid in Novem...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-06-16 00:00:00
abstract：OBJECTIVE:The object of this study to analyse and compare the efficacy of the classic language tasks (repetition, phonological fluency and lexical decision), for the purpose of identifying the dominant hemisphere for language by means of functional magnetic resonance. SUBJECTS AND METHODS:The three tasks were performa...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-07-16 00:00:00
abstract：AIM:To report a case of sub-acute encephalopathy with all the extension study negative and with response to steroid therapy. CASE REPORT:The study involves a 22-year-old female with no relevant past history who presented symptoms of sub-acute encephalopathy consisting in behavioural disorders, generalised seizures and...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：:Today, the fact that sensory integration difficulties with a neurological basis exist and that they seriously condition the development of those individuals who suffer from them is widely accepted and acknowledged as being obvious by the vast majority of professionals working in the field of community healthcare. Howe...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-02-24 00:00:00
abstract：INTRODUCTION:Hypophonia has been defined as a reduction in speech volume. It is an uncommon finding in acute stroke, mainly related to multiple deep infarcts. CLINICAL CASE:An 82 year old hypertensive woman was admitted to our hospital presenting acute right sided weakness and low speech volume. She was hypophonic and...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-10-16 00:00:00
