Abstract：
AIM:To describe clinical results and complications derived from vagal nerve stimulation therapy in drug resistant epileptic patients unsuitable for other surgical treatments, since the first implant in an epilepsy national referral centre. PATIENTS AND METHODS:A retrospective analysis of the patients implanted in our centre was held. Data related to baseline characteristics of their epilepsy and therapy complications was collected. RESULTS:32 new implants in 31 patients are included, mean age of 34 years, 29.3 years of disease evolution, three anti-epileptic drugs at surgery and a postoperative follow-up of 4.03 years. Complex partial seizures types (71.9%) and cryptogenic aetiology (59.4%) were the most frequent. 75% of patients hadn't history of previous epilepsy surgery. 43.8% of patients had a seizure frequency improvement above 50%, with a better response in patients with complex partial seizures (p = 0.22) and cryptogenic aetiology. None statistical significance was found between antiepileptic drugs and seizure frequency. Dysphonia, hoarseness and dysphagia, mostly transient, were the side effects registered. There was an asystole during surgery, completely recovered. One device was replaced due to hardware rupture after a seizure related trauma, one had to be adjusted due to a previous vocal cord paresis, and one dysfunctioning device was removed. In 84.4% the tolerance was excellent. CONCLUSIONS:Vagal nerve stimulation is an effective treatment for significant seizure frequency improvement of resistant patients untreatable with other medical or surgical treatments. Further studies are needed to predict the individual response of each patient to therapy and optimizing indications, therefore contributing to cost/benefit optimization. TITLE:Resultados de la estimulacion del nervio vago en pacientes con epilepsia farmacorresistente en un centro de referencia nacional de epilepsia. :Objetivos. Describir los resultados clinicos y complicaciones derivados de la estimulacion vagal en pacientes con epilepsia farmacorresistente no tributaria de otras modalidades de tratamiento quirurgico, desde el primer implante en un centro de referencia nacional. Pacientes y metodos. Se realizo un analisis retrospectivo de los pacientes implantados en nuestro centro y se extrajeron datos relativos a las caracteristicas basales de su epilepsia y complicaciones derivadas. Resultados. Se incluyeron 32 nuevos implantes en 31 pacientes, con una edad media de 34 años, evolucion de enfermedad de 29,3 años, tres farmacos antiepilepticos prequirurgicos y 4,03 años de seguimiento. Las crisis parciales complejas (71,9%) y criptogenicas (59,4%) fueron el tipo y la etiologia de crisis mas frecuentes. El 75% no tenia antecedentes quirurgicos de epilepsia. Un 43,8% presento mejoria igual o superior al 50%, mayor en las epilepsias parciales complejas (p = 0,22) y la etiologia criptogenica. No se hallo asociacion estadistica entre ajustes de medicacion y frecuencia de las crisis. Los efectos secundarios encontrados fueron disfonia, ronquera y disfagia transitorias, y una asistolia intraoperatoria recuperada. Se realizo un recambio por ruptura de hardware postraumatica. Un paciente con paresia preexistente de cuerda vocal presento estridor laringeo que requirio ajuste de intensidad, y se produjo una retirada del sistema por disfuncion. En el 84,4%, la tolerancia fue excelente. Conclusiones. Constituye un tratamiento efectivo para mejorar significativamente la frecuencia de crisis de los pacientes farmacorresistentes y con contraindicacion para otras modalidades de tratamiento quirurgico. Se precisan futuros estudios para predecir la respuesta individual de cada paciente, optimizar las indicaciones y mejorar la relacion coste/beneficio.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Roldan-Ramos P,Reyes-Figueroa LA,Rumia J,Martinez-Lizana E,Donaire A,Carreno-Martinez Msubject
Has Abstractpub_date
2016-11-01 00:00:00pages
403-410issue
9eissn
0210-0010issn
1576-6578pii
rn2015392journal_volume
63pub_type
杂志文章abstract：INTRODUCTION:Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units. AIM:To evalu...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-10-16 00:00:00
abstract：INTRODUCTION:Lymphomas of the central nervous system include primary and secondary lymphomas of Hodgkin and non-Hodgkin types. For a long time central nervous system involvement during the course of systemic non-Hodgkin lymphoma has been considered unusual, to occur late on in the disease process and usually to be loca...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:We analyze the main factors influencing the time delay between onset and admission to the hospital in acute stroke. PATIENTS AND METHODS:Consecutive series of 1,344 patients with acute stroke or transient ischemic attack admitted at two reference hospitals of Valencia and included at the sam...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：INTRODUCTION:The developmental amnesia is a recently known entity that occurs as a consequence of hypoxic-ischemic events in the perinatal period. This is a specific deficit of episodic memory with greater preservation of semantic memory and other memory components such as the immediate and working memory. It occurs in...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Epilepsy is one of the most common neurological disorders, affecting about one percent of the world population. Pharmacological treatment fails in one-third of these patients. Surgical intervention has become an accepted treatment option for those patients with seizure disorders that are refractory to conv...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:The treatment of non traumatic intra cerebral haemorrhage is one of the therapeutic challenges at the present time. In spite of present day technology and advances in understanding its physiopathology, the prognosis is the same as it was fifteen years ago. We review the surgical treatments us...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:To determine clinical and pathological features with seizures associated brain tumors. PATIENTS AND METHODS:This was a retrospective study through of an Epilepsy Program Protocol where we studied fifty patients admitted at Hospital Universitário Cajuru of Curitiba, Brazil, in 1996-1997. RESULTS:We studied 3...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：INTRODUCTION:Temporal orientation is a component of most screening tests for diagnosing cognitive impairment. Correct temporal orientation involves activating both semantic information (concepts of the calendar date) and episodic information (remembering the current date). AIMS:The aim of this study was to assess the ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-16 00:00:00
abstract：INTRODUCTION:Neuronal ceroid lipofuscinosis (NCL), represents a group of inherited neurodegenerative disorders. Based on the age of the patient at onset, clinical course and ultrastructural morphology it has been identified three clinical types for the pediatric group: 1) Infantile NCL (INCL); 2) Late infantile NCL (LI...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Virtual reality allows the user to interact with elements within a simulated scene. In recent times we have been witness to the introduction of virtual reality-based devices as one of the most significant novelties in neurorehabilitation. AIM:To review the clinical applications of the developments based o...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-10-16 00:00:00
abstract：OBJECTIVE:To show the neurological disorders associated with ocular changes mainly affecting retina and which can be seen during the first year of age. DEVELOPMENT:It is used the personal experience and the reported papers of the literature related with the subject to make a short review of the main neurological, bioc...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：INTRODUCTION:The theory of memory consolidation, based on the work published by Georg Elias Muller and Alfons Pilzecker over a century ago, continues to guide research into the neurobiology of memory, either directly or indirectly. In their classic monographic work, they concluded that fixing memory requires the passag...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
abstract：INTRODUCTION:Between 5 and 48% of the patients with Behçet s disease have neurological abnormalities. In children, meningoencephalitis as an initial manifestation of the disease is not frequent. CASE REPORT:We present a four years old girl with a Behçet s disease. When she was six months of age, during an hospitalizat...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：INTRODUCTION:Alterations in SCN1A gene cause most cases of Dravet syndrome. This finding has increased scientific interest in the syndrome, helping to better define its clinical features and facilitating treatment. AIMS:To update the knowledge on Dravet syndrome and to discuss the role of the molecular studies in impr...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:The risk of falls in older adults increases because of the decrease in strength, flexibility, balance and sensory changes affecting functionality and quality of life. For this reason, an integral system of evaluation of equilibrium is necessary, for preventive purposes or for early therapeutic intervention...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-11-16 00:00:00
abstract：INTRODUCTION:Congenital hydrocephalus or ventriculomegaly is a disorder that now can be diagnosed in uterus with ultrasonography, this gives the chance of being able to give a treatment the earliest as possible. DEVELOPMENT:The clinical manifestations are reviewed, the diagnosis, the frequent treatment and causes of c...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-10 00:00:00
abstract：:The new communication techniques and, particularly, Internet, are changing our way of collaborating, relating to each other and searching for information, paving the way for telemedicine. Such initiatives are described in the Revista de Neurologia, as well as the methodology followed to prepare the first Electronic Fo...
journal_title：Revista de neurologia
pub_type： 社论
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:The damage caused to the central nervous system by lightning can be immediate or delayed. Cerebrovascular accidents are usually an infrequent complication of lightning strikes. CASE REPORT:We report the case of a patient who was hit by lightning and then developed an acute bilateral intraparenchymatous ha...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-16 00:00:00
abstract：INTRODUCTION:The description of Upper Airway Resistance Syndrome (UARS) let us to recognize the importance of the pair 'respiratory effort-arousal' on sleep-disordered breathing pathophysiology. DEVELOPMENT:First part of this paper reviews knowledge about respiratory arousal pathophysiology. Arousal response is normal...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-16 00:00:00
abstract：INTRODUCTION:Diagnostic criteria of transient global amnesia (TGA) establishes that memory functioning has to be recovered in 24 hours. However, there are contradictory data about the existence of long-term sequelae. Furthermore, there is no consensus about which is the most suitable tool in order to use in the assessm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To observe the frequency of various psychiatric disorders (depressive disorders, anxiety state and paraphrenic-paranoid disorders). PATIENTS AND METHODS:This study includes the 'cases' of dementia detected in an epidemiological field study done door-to-door, double phased and including non-institutionalized ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:Semantic dementia is a progressive, relatively selective disorder affecting the semantic system with involvement of the verbal and non-verbal functions. The clinical picture is well characterised despite the confusion that may be generated by the different ways of classifying it. AIM. To determine the clin...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:Malaria is one of the main health problems in the Third World. Plasmodium falciparum infects as many as 300 million people, causing up to three million deaths each year, most of which occur in African children. Cerebral malaria is the most common lethal complication of P. falciparum infection in children a...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The term 'acute myelopathies'--referred to a spinal cord dysfunction--represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. The objective of this review is to discuss the non-traumatic acute myelopathies. Acute myelopathy can be due to several causes as...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-06 00:00:00
abstract：INTRODUCTION:A great deal of research has addressed problems in the correct acquisition of language, but with few overall conclusions. The reasons for this lie in the individual variability, the existence of different measures for assessing language and the fact that a complex network of genetic and environmental facto...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician. It is also less invasive than other methodologies and is in accordance with the ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-01-16 00:00:00
abstract：INTRODUCTION:Dreams are a universal human experience and studying them from the point of view of neuroscience, consciousness, emotions and cognition is quite a challenge for researchers. Thus, dreams have been addressed from a number of different perspectives ranging from philosophy to clinical medicine, as well as psy...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-16 00:00:00
abstract：INTRODUCTION:Attention deficit hyperactivity disorder (ADHD) is a neurobiological condition essentially characterised by inattention, hyperactivity and impulsiveness, and has a prevalence of around 5%. Because it is a biological disorder, both boys and girls with ADHD display these same symptoms, but more boys are diag...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-03-02 00:00:00
abstract：INTRODUCTION:Severe myoclonic epilepsy in infancy (SMEI), or Dravet s syndrome, is one of the most serious forms of epilepsy in infancy. In this study we analyse the clinical characteristics of the process. PATIENTS AND METHODS:The cases reported in the literature are surveyed, together with a personal casuistic, from...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：INTRODUCTION:The combination of subarachnoid hemorrhage (SAH) and subhyaloid hemorrhage is known as 'Terson syndrome'. Retinal hemorrhage is commonly observed clinically in the optic fundi of patients with SAH, however, subhyaloid hemorrhage of the globe in the setting of SAH has been rarely on CT of the brain. Several...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
