Abstract:
INTRODUCTION AND OBJECTIVE:It is well known that in aged animals cognitive deficit occurs, homologous with that occurring in Alzheimer's disease in humans, and as has been shown in others species, this may be attenuated by administration of nerve growth factor (NGF). Therefore the basic aim of this study was to make an electrophysiological evaluation of the repercussion that there might be after long-term administration of this neurotropin in the sacred baboon (Papio hamadryas) comparing aged with young animals. MATERIAL AND METHODS:We studied a six year old male and a 39 year old female, after sedation. Long-term intraventricular administration of NGF was carried out using a continuous infusion pump, at a dose of 2.1 micrograms/kg/day. Recordings were made before installing the pump and 1, 3 and 6 months after insertion. A Neuropack Four-mini set for evoked potentials (Nihon Kohden) was used to record auditory evoked potentials from the brain stem and visual evoked potentials due to flash. RESULTS AND CONCLUSION:In both animals there were modifications of their electrophysiological responses. These reached a maximum after one month, more markedly in the older animal and this could possibly be related to the neuromodulator effect of NGF.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Báez MM,Morales L,Fernández CI,Cabrera I,González O,Padilla E,Zaldívar Msubject
Has Abstractpub_date
1999-04-01 00:00:00pages
665-8issue
7eissn
0210-0010issn
1576-6578journal_volume
28pub_type
杂志文章abstract:INTRODUCTION:As result of our aim to improve the quality standard of our emergency system, work has been carried out in relation to the development and monitorization of effective clinical protocols in the department of paediatric practice. PATIENTS AND METHODS:An evidence based review approach was taken to design a c...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-08-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
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更新日期:1999-11-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-10 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
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更新日期:2003-10-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-12-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6905.2019047
更新日期:2019-09-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-06-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-08-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-06-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-06-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1997-05-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:
更新日期:2014-02-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-08-01 00:00:00
abstract:INTRODUCTION:Developmental disorders are a common pathological condition in Neuropaediatrics and do not usually present characteristic anatomical alterations in the different neuroanatomical imaging tests that can be employed, such as computerised axial tomography or magnetic resonance (MR). Positron emission tomograph...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,meta分析
doi:
更新日期:2003-03-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6906.2019061
更新日期:2019-09-16 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-12-01 00:00:00