[Quantitative and cytomorphometric analysis of glial population in the frontal cortex of contralaterally lesioned rats].

Abstract:

INTRODUCTION:In the last years, the changes in glial cells during different alterations in the Central Nervous System have been studied. It is known that astrocytes and microglial cells are the glial cells which present the major reactivity. OBJECTIVE:The aim of this work was to analyze the glial cell changes induced by a lesion. MATERIAL AND METHODS:We studied the quantitative and morphometric changes observed in glial cells in the different layers of contralateral frontal cortex using micrometric techniques and image analysis. RESULTS:In contralateral side to the lesions, we observed an increase in the total glial cells in all the cortical layers. The astrocytes only increased their number in cortical layer I, but microglia and oligodendrocytes increased in all the layers. In the cytomorphometric analysis an increase in the nucleus area of astrocytes was observed. CONCLUSION:The glial cell response to the lesions is different for astrocytes, microglia and oligodendrocytes but these changes affected to all the cortical layers.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Ramírez-Expósito MJ,Martínez-Martos JM

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

396-403

issue

5

eissn

0210-0010

issn

1576-6578

journal_volume

29

pub_type

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