[Neurochemistry of Parkinson's disease and parkinsonism plus].

Abstract:

:The neurochemistry of Parkinson's disease and other degenerative parkinsonisms is reviewed, emphasizing the changes described in the dopaminergic system. Presynaptic dopaminergic markers are reduced over the striatum in all these degenerative parkinsonisms, dopamine receptor changes being more heterogeneous. While in Parkinson's disease D1 and D2 receptors remain preserved as compared to controls, in progressive supranuclear palsy there is a loss of nigral D1 receptors and of striatal D2 receptors. This finding has also been described in striatonigral degeneration. There are no clear data about the status of D3, D4 and D5 dopamine receptors in these conditions. The alterations in other neurotransmission systems, cholinegic, adrenergic, serotoninergic and peptidergic are, in general, less dramatic, although they have not been studied in detail. To conclude, further studies are necessary in these field, in these moment, however, the preservation of striatal D2 dopamine receptors is the neurochemical finding with the best correlation with the response to levodopa or other dopaminergic agonists.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Pascual J,Misiego M

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

S141-6

eissn

0210-0010

issn

1576-6578

journal_volume

25 Suppl 2

pub_type

杂志文章,评审
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    authors: Prats Viñas JM,Garaizar C,Martínez González MJ,García Ribes A

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    authors: Bilbao Bilbao A,Seisdedos N

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  • [Attention deficit hyperactivity disorder in teenagers: appraisal of the EDAH (a) scale].

    abstract:AIMS:To appraise the attention deficit hyperactivity disorder assessment scale for a teenage population, EDAH (a). SUBJECTS AND METHODS:From an initial sample of 3400 participants, a final sample of 2292 pupils between 12 and 16 years of age were finally selected. Of the total number, 1066 were boys (46.5%) and 1226 w...

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    doi:

    authors: Sánchez CR,Díaz F,Ramos C

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  • [Diagnostic challenges in epilepsy].

    abstract:INTRODUCTION:Epileptic seizures and epilepsy are part of daily clinical practice in neurology. Yet, the number of false positive diagnoses is surprisingly high. Almost one out of every five patients treated for epilepsy does not really have this diagnosis, which is a high percentage bearing in mind the social and medic...

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  • [Rett's syndrome. Clinical features and advances in genetics].

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    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Temudo T,Maciel P

    更新日期:2002-02-01 00:00:00

  • [Mitochondrial DNA depletion syndrome-13: a case with an unusual onset].

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    journal_title:Revista de neurologia

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  • [Benign idiopathic external hydrocephalus (benign subdural collection) in 39 children: its natural history and relation to familial macrocephaly].

    abstract:INTRODUCTION:Benign idiopathic external hydrocephalus (BIEH) is an age-dependent disorder that is self-limiting in time and has an uncertain aetiology. PATIENTS AND METHODS:A retrospective study was conducted involving 39 patients (16 girls and 23 boys) with BIEH. The following data were analysed for each patient: age...

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    pub_type: 杂志文章

    doi:

    authors: Castro-Gago M,Pérez-Gómez C,Novo-Rodríguez MI,Blanco-Barca O,Alonso-Martin A,Eirís-Puñal J

    更新日期:2005-05-01 00:00:00

  • [Neurocutaneous syndromes with vascular alterations].

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    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: de Felipe I,Quintanilla E

    更新日期:1997-09-01 00:00:00

  • [Hereditary ataxias].

    abstract:INTRODUCTION AND OBJECTIVE:The hereditary ataxias form a large, complex group of entities whose recognition is essential for correct genetic assessment, satisfactory clinical control and in some cases a suitable therapeutic approach. The clinico-semiological variety and advances in molecular biology have made the hered...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Ruggieri VL,Arberas CL

    更新日期:2000-08-01 00:00:00

  • [Hirayama disease in paediatrics: a clinical case report and review of the literature].

    abstract:INTRODUCTION:Hirayama disease is a rare children's muscular atrophy that affects young Asian males, with muscular atrophy usually in one of the upper limbs that progresses slowly and later stabilises. It is diagnosed by means of electromyographic/electroneurographic with conduction speed studies (EMG/ENG-CS) and by mag...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Martínez-Cayuelas E,Martínez-Salcedo E,Alarcón-Martínez H,Puche-Mira A,Domingo-Jiménez R,de Mingo-Casado P,Serrano-García C

    更新日期:2015-04-01 00:00:00

  • [A brief questionnaire for the diagnosis of maladaptive behavior disorders in adolescents aged between 12 and 16 years of age].

    abstract:OBJECTIVE:To standardize and to determine the structural validity of a conduct disorder self report questionnaire in adolescents. PATIENTS AND METHODS:One hundred ninety, 12 to 16 year old male participants from the different socioeconomic status were randomized selected from educational institutions of Medellin City,...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Pineda DA,Puerta IC,Arango CP,Calad OM,Villa MT

    更新日期:2000-06-16 00:00:00

  • Hazardous alcohol consumption and risk of alcohol dependence present different neurophysiological correlates.

    abstract:INTRODUCTION:Hazardous alcohol consumption (HAC) is a pattern of alcohol use that may result in harm for the user and/or for those around them. Prior research has suggested that HAC and alcohol dependence share some neurophysiological features but differ in others. AIM:To determine whether HAC and alcohol dependence p...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Herrera-Morales WV,Ramirez-Lugo L,Santiago-Rodriguez E,Reyes-Lopez JV,Nunez-Jaramillo L

    更新日期:2019-02-16 00:00:00

  • [Repetitive actions and trial and error].

    abstract:TITLE:Actos reiterativos y ensayo-error. : ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Mulas F

    更新日期:2016-01-01 00:00:00

  • [Non-cognitive aspects of dementia].

    abstract:OBJECTIVE:To observe the frequency of various psychiatric disorders (depressive disorders, anxiety state and paraphrenic-paranoid disorders). PATIENTS AND METHODS:This study includes the 'cases' of dementia detected in an epidemiological field study done door-to-door, double phased and including non-institutionalized ...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Vilalta-Franch J,Llinàs-Reglà J,López-Pousa S

    更新日期:1998-09-01 00:00:00

  • [The medulloblastoma].

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    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Figols-Ladrón de Guevara J,Lafuente-Sánchez JV

    更新日期:2006-08-16 00:00:00

  • [Late-onset migraine equivalent with prolonged aura and altered brain perfusion].

    abstract:TITLE:Equivalente migrañoso de inicio tardío con aura prolongada y alteración de la perfusión cerebral. : ...

    journal_title:Revista de neurologia

    pub_type: 信件

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    authors: Mayà-Casalprim G,Rudilosso S,Serrano E,Reyes-Leiva D,Escudero-Rubí D,Obach-Baurier V

    更新日期:2020-06-01 00:00:00

  • [Overestimation of the degree of stenosis in the intracranial internal carotid artery determined by magnetic resonance angiography compared to conventional arteriography].

    abstract:INTRODUCTION:In the evaluation of stenoses of the extracranial internal carotid artery (ICA), there are studies that suggest that magnetic resonance angiography (MRA) can be a substitute for conventional arteriography (CA), although it seems it has a tendency to overestimate the degree of stenosis. No similar compariso...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Durán-Ferreras E,Schoeck AP,Barest GD,Viereck JC,Babikian VL,Kase CS

    更新日期:2003-10-16 00:00:00

  • [Meningitis due to Salmonella in the neonatal period].

    abstract:INTRODUCTION:Meningitis due to Salmonella is an unusual sign of salmonellosis. Usually Salmonella causes clinical disorders of the digestive tract, but on occasions, especially in babies, may cause focalized infections such as meningitis. Although meningitis due to Salmonella is unusual, it should be remembered because...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Vázquez-López ME,Pego R,Somoza C,García-Plata C,Rodríguez-De la Riva P,Morales-Redondo R

    更新日期:1998-12-01 00:00:00

  • [Neuropathological findings in early-onset Alzheimer's disease (E280a-PS1 mutation)].

    abstract:INTRODUCTION AND MATERIAL:Nine brains belonging to early onset Alzheimer disease (E280A-PS1 mutation) affected individuals from Antioquia, Colombia, were analyzed by neuropathological standard techniques. All individuals were ascertained from genealogies descendents from a common ancestor that shows a dominant autosomi...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Duque-Castaño A,Roldán MI,Arango-Viana JC,Arcos-Burgos M,Cubillo H,Lopera F

    更新日期:1999-07-01 00:00:00

  • [Functional hemispherectomy: long-term follow-up in a series of five patients].

    abstract:INTRODUCTION:Functional hemispherectomy consists in palliative epilepsy surgical procedure usually performed in patients with pharmaco-resistant epilepsy and hemispheric syndromes. It is based on the neural disconnection of the affected hemisphere with preservation of the vascular supply. AIM:To analyze long-term prog...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Rodriguez-Osorio X,Lopez-Gonzalez FJ,Eiris-Punal J,Frieiro-Dantas C,Gomez-Lado C,Peleteiro-Fernandez M,Prieto-Gonzalez A

    更新日期:2018-03-01 00:00:00

  • [Parkinson's disease, tobacco and age: meta analysis].

    abstract:INTRODUCTION:Epidemiological studies have demonstrated contradictory results about the association between smoking and the risk of Parkinson s disease (PD). OBJECTIVE:Examine the hypothesis of the EUROPARKINSON group that smoking protects against PD only in patients below 75 years of age. MATERIAL AND METHODS:We cond...

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    pub_type: 杂志文章,meta分析

    doi:

    authors: Allam MF,del Castillo AS,Navajas RF

    更新日期:2003-03-16 00:00:00

  • [Spanish validation of the Iowa Rating Scale for Personality Change (IRSPC) for the appraisal of changes in personality in patients with acquired brain injury].

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    pub_type: 杂志文章

    doi:

    authors: Guallart-Balet M,Jiménez-Cortés MP,Tuquet-Calvo H,Pelegrín-Valero C,Olivera-Pueyo J,Benabarre-Ciria S,Tirapu-Ustárroz J

    更新日期:2015-01-01 00:00:00

  • [Bromocriptine: could it be the cure for post-surgical akinetic mutism?]

    abstract:INTRODUCTION:Akinetic mutism is considered as an alteration of the motivational state of the person, which the patient is unable to initiate verbal or motor responses voluntary, even with preserved sensorimotor and surveillance functions. CASE REPORT:A 43 year-old male involved in a cerebellum arteriovenous fistula co...

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    pub_type: 杂志文章

    doi:

    authors: Arevalo-Saenz A,Pedrosa-Sanchez M,Sola RG

    更新日期:2017-01-16 00:00:00

  • [Progressive myoclonic epilepsy as a sign of a late form of Alpers syndrome].

    abstract:INTRODUCTION:Progressive cerebral polidystrophy or Alpers syndrome is a clinico-pathological picture, with no specific biological marker, characterized by involvement mainly of the cerebral grey matter and which shows clinically as a rapidly progressive encephalopathy with intractable seizures, usually myoclonic. The t...

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    pub_type: 杂志文章

    doi:

    authors: Galván-Manso M,Tabuenca Y,Medrano P,Ruiz-Escusol S,Giménez-Mas JA,López-Pisón J

    更新日期:2000-12-01 00:00:00

  • [Nocturnal polysomnogram in childhood autism without epilepsy].

    abstract:AIMS:To evaluate the presence of epileptiform discharges and the organisation of nocturnal sleep of autistic children without nocturnal polysomnographic epileptic seizures. SUBJECTS AND METHODS:Cross section analysis. SUBJECTS:21 boys and girls with autistic spectrum using DSM IV criteria between the ages of 4 and 12...

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    pub_type: 杂志文章

    doi:

    authors: Valdizán-Usón JR,Abril-Villalba B,Méndez-García M,Sans-Capdevila O

    更新日期:2002-06-16 00:00:00

  • [Wolf-Hirschhorn syndrome: just a citation omission? Reply].

    abstract:TITLE:Sindrome de Wolf-Hirschhorn: simple omision al citar? Replica. ...

    journal_title:Revista de neurologia

    pub_type: 评论,信件

    doi:

    authors: Blanco-Lago R

    更新日期:2017-09-01 00:00:00

  • [Improvements in the diagnosis of dystrophinopathies: what have we learnt in these last 20 years?].

    abstract::INTRODUCTION. Dystrophinopathies are X-linked genetic disorders caused by mutations in the DMD gene. Genetic tests are of utmost importance for management and genetic counseling of these diseases. However, the complexity of the DMD gene is a challenge for diagnosis. AIM. To describe recent advances in the diagnosis of...

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    pub_type: 杂志文章,评审

    doi:

    authors: López-Hernández LB,Ayala-Madrigal ML,van Heusden D,Estrada-Mena FJ,Canto P,Sandoval-Ramírez L,Gómez-Díaz B,Coral-Vázquez RM

    更新日期:2011-02-16 00:00:00

  • [Metabolic imaging by positron emission tomography using [18F] fluorodeoxiglucose in developmental disorders].

    abstract:INTRODUCTION:Developmental disorders are a common pathological condition in Neuropaediatrics and do not usually present characteristic anatomical alterations in the different neuroanatomical imaging tests that can be employed, such as computerised axial tomography or magnetic resonance (MR). Positron emission tomograph...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Maldonado A,Garcia L,Resino MC,Dominguez ML,Muñoz JA,Otero C

    更新日期:2004-02-01 00:00:00

  • [The evaluation of the effects of pharmacological treatment of children with attention deficit hyperactivity disorder].

    abstract::In this study we approach problems related to the dosage and specific action of methylphenidate, its effects at cognitive and social levels, possible side-effects and limitations to its usage, and methods for evaluation of the response to treatment in the school environment. We make special mention of the importance o...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Roselló B,Amado L,Presentación MJ

    更新日期:1999-02-01 00:00:00

  • Lacunar stroke associated headache is not related to intracranial large vessel disease.

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    pub_type: 杂志文章

    doi:

    authors: Ferro JM,Salgado AV,Oliveira V

    更新日期:1995-07-01 00:00:00