Abstract：
INTRODUCTION:Progressive supranuclear palsy is a disease that normally presents only sporadically in adults and courses in a progressive, chronic manner. It is characterised by the presence of supranuclear ophthalmoplegia, postural instability, a Parkinsonian syndrome, pseudobulbar affect, cervical dystonia and cognitive impairment. PATIENTS AND METHODS:We conducted a descriptive study of clinical and epidemiological features in a series of 18 patients who satisfied the mandatory NINDS-SPSP clinical eligibility criteria for the likely diagnosis of progressive supranuclear palsy, using the scale developed by Golbe et al. RESULTS AND CONCLUSIONS:The mean age of onset of the disease was 58.6 +/- 8.2 years, 55.5% of the patients were males, the average history of the disease at the time of diagnosis was 4.39 +/- 2.3 years, and there was a diagnostic subregister in the first 4 years of the disease. Gait disorders, falls and slowness were the most frequently observed presenting forms of the disease. During their first four years with the disease, 75% of the patients were totally independent when it came to carrying out activities of daily living, whereas after the fourth year there was a predominance of the need for aid and absolute dependence. Dysphagia was more frequent in the later stages of the disease. Ocular motility disorders and impaired cognitive functioning were obvious in the initial stages of the disease, and there was a strong correlation between the length of time the disease had been coursing and the severity of the ocular and cognitive disorders.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Alvarez-González E,Maragoto-Rizo C,Arteche-Prior M,Pérez-Parra S,Carballo M,Alvarez-González Lsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
1006-10issue
11eissn
0210-0010issn
1576-6578pii
rn2003435journal_volume
39pub_type
杂志文章abstract：INTRODUCTION:Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics. In spite of being a safe and effective anticonvulsant, VPA has been involved in the onset of changes in the metabolism of ammonia and carnitine, although few prospective studies have been made of this. OBJECTIVES:To evaluate the effe...
journal_title：Revista de neurologia
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abstract：INTRODUCTION:Inappropriate admissions to a hospital service generate unnecessary costs for our health care service. Most admissions to a hospital service come from the emergency department. The presence of a neurologist to attend hospital emergencies would be an important factor allowing admission criteria to be stream...
journal_title：Revista de neurologia
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更新日期：2006-12-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2014-05-16 00:00:00
abstract：INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relap...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
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更新日期：2018-06-16 00:00:00
abstract：OBJECTIVE:To analyze the available scientific evidence regarding treatment with thrombolytic agents in patients with cerebrovascular disease and present this in the context of daily practice. DEVELOPMENT:Publication of the NINDS study of treatment with t-PA for acute cerebral ischemia led to approval of this treatment...
journal_title：Revista de neurologia
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更新日期：1999-12-16 00:00:00
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更新日期：1998-11-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2010-04-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：TITLE:Polimiositis secundaria a un linfoma no Hodgkin. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2017-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2004-07-16 00:00:00
abstract：INTRODUCTION:The value of the P300 cognitive event-related potential in the diagnosis of Alzheimer subtype neurocognitive disorders is still incipient. Recent studies suggest that combining it with neuropsychological tests by cognitive domains would allow an objective and early characterisation of the cognitive impairm...
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pub_type： 杂志文章
doi：10.33588/rn.7101.2019341
更新日期：2020-07-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-05-21 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-12-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Cavernous angiomas account for 5-13% of all vascular malformations. In 75% of cases they are situated in the posterior fossa and up to 30% are associated with abnormal venous drainage. The main complication is haemorrhage; the presence of a neurological focus without radiological evidence of bleeding is ve...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2007-12-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 信件
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更新日期：2019-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 评论,信件
doi：10.33588/rn.7111.2020568
更新日期：2020-12-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2004-04-16 00:00:00
abstract：INTRODUCTION:Aseptic meningitis is a process that is characterised by an inflammatory reaction of the meninges that is not due to any infectious agent. Its aetiology is varied and is most frequently caused by rheumatologic and/or autoimmune processes, chemical or medication-induced meningitis, the most notable drugs in...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2006-02-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-08-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：2000-06-01 00:00:00
