Abstract：
OBJECTIVES:To review current knowledge regarding the mechanisms of action, pharmacokinetics, clinical efficacy and the tolerance of topirimate (TPM) and describe the Spanish experience of the use of this drug in 224 patients of all ages. DEVELOPMENT:TPM is a new drug which affects practically all the mechanisms involved in the production of epileptic seizures, which means that it is a broad-spectrum antiepileptic drug. After reviewing the mechanisms of action and pharmacokinetic characteristics of TPM, we consider the efficacy of the drug in 224 patients of all ages with all types of epileptic seizures. CONCLUSIONS:In patients of all ages with uncontrolled epileptic seizures treated with TPM, the frequency of their seizures was reduced by over 50% in 78% of the patients and the seizures were abolished in 25% of the total cases. The drug was generally well tolerated. Side-effects leading to suspension of the drug occurred in only 5% of the cases. TPM is an effective drug which is well tolerated in patients of all ages and with all kinds of epilepsy.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Herranz JLsubject
Has Abstractpub_date
2000-06-01 00:00:00pages
S132-6eissn
0210-0010issn
1576-6578journal_volume
30 Suppl 1pub_type
杂志文章,评审abstract：INTRODUCTION:Critical illness patients may show marked weakness acquired in the Intensive Care Unit (ICU). There are some disagreements about the myopathic versus neuropathic damage in this condition, presumably due to the lack of reliable diagnostic criteria. AIMS:To report the neurophysiological findings in critical...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2010-06-16 00:00:00
abstract：INTRODUCTION:The incidence in the central nervous system diseases has increased with a growing elderly population. Unfortunately, conventional treatments used to treat the mentioned diseases are frequently ineffective due to the presence of the blood brain barrier. AIM:To illustrate the blood-brain barrier properties ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:When the clinical picture consists of prominent cognitive impairments (e.g. amnesia) with relatively mild behavioral symptoms, it can be very difficult to distinguish frontal lobe dementia (FLD) from Alzheimer disease (AD). However, these conditions may have distinct cognitive profiles that c...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:Attention deficit hyperactivity disorder (ADHD) is one of the most frequent reasons for visits to neuropaediatric services. Although the clinical criteria are well established, the medical history is probably not examined with enough care and the most decisive symptoms go unnoticed. AIM. To review a clinic...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：AIM:Different patients exhibit wide variability in the way they respond to medications. Individual differences in drug response can result from environmental factors, as well as genetic determinants. In particular, inherited differences in the metabolism and disposition of drugs can have a great influence on the effica...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：INTRODUCTION:Cerebral vascular malformations (CVM) are a heterogeneous group of lesions. One way of classifying them is according to histological criteria, clinical features, imaging findings, electroencephalography and distinctive pathology. OBJECTIVES:To report the results obtained in 16 patients clinically diagnose...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：INTRODUCTION AND AIMS:Chronic immune-mediated neuropathies are characterised by their being predominantly demyelinating, by being associated to specific antibodies and by their response to immunotherapy. We evaluated the clinical, electrophysiological and immunological responses following treatment with intravenous imm...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-03-16 00:00:00
abstract：INTRODUCTION:Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units. AIM:To evalu...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-10-16 00:00:00
abstract：INTRODUCTION AND AIMS:The degree of stenosis measured by Doppler ultrasonography in patients with contralateral occlusion of the internal carotid artery (ICA) is assumed to be overestimated. We propose to measure the extent to which this phenomenon affects the capacity of Doppler ultrasonography to classify stenoses. ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-04-16 00:00:00
abstract：:Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-16 00:00:00
abstract：INTRODUCTION AND METHOD:The issue regarding the relations between behaviour and the brain is no longer the specific goal of neuropsychology, but rather that of the coordinated multidisciplinary activity of all the disciplines that go to make up the neurosciences. The specific contribution of neuropsychology to this mul...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:The relationship between Chlamydia pneumoniae and atherosclerosis has been assessed in several studies. Development and conclusions. Their results suggest a possible role of Chlamydia pneumoniae in the origin and development of the disease, while the actual link between them are still unknown. However, the...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
abstract：:We present the association of a distrophinopathy with a case of facioscupulohumeral dystrophy in two individuals belonging to the same family. The discrepancy in the seric creatinphosphokinase (CPK) of the two patients together with certain clinical data suggests the possibility that it is a question of two different ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：INTRODUCTION:Despite progress in understanding its pathogenesis, there has not yet been found any independent predictive marker of aggressive behavior of pituitary adenomas, to facilitate the treatment and monitoring of patients. AIM:To analyze the expression of folliculo-stellate cells by immunostaining with S-100 pr...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:The influence of psychosocial stress on the origin of acute cerebral vascular disease (CVD) has received very little attention. The objective of this paper is to evaluate the role of psychosocial stress due to events occurring in daily life as a risk factor (RF) in acute CVD. MATERIAL AND METHODS:A case-c...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown. Nevertheless, one of the most acceptable possibilities facing the origin of the tumor is the remaining rests of cere...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-16 00:00:00
abstract：OBJECTIVES:Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population. SUBJECTS AND METHODS:By means of PCR RFLP analysis of DNA from patients (NINCS ADRDA criteri...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：INTRODUCTION:Transient ischemic attacks (TIA) often precede a stroke. AIMS:The purpose of this study is to examine the modifiable cardiovascular risk factors for non-cardioembolic TIA. PATIENTS AND METHODS:A population based case control study was conducted in a district within the city of Barcelona. The cases were 1...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:The lack of univocal diagnostic biological markers which are easily reproducible, highly specific and sensitive has propitiated the apparition of a conjunct of neuropsychological instruments for the detection and evaluation of dementias. The main markers are reviewed in this paper, the third of three papers dedicated ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:The epilepsies of childhood are much more variable in expression and outcome than those of adults: the clinical and EEG features of epilepsy can change considerably with age. DEVELOPMENT:The neonatal epileptic encephalopathy, West and Lennox syndromes are present at different age, and each one shows a ste...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：INTRODUCTION:It has been previously shown that cluster headache (CH) can involve some extratrigeminal areas. Occipital pain has been recognized in several patients, even as the origin of the attacks. Nevertheless, the proposals of topographic variations of CH have been mainly focused on the location of pain in either s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-04-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-16 00:00:00
abstract：INTRODUCTION:In Parkinson's disease there are patients with isolated and multiple cognitive impairment, and their cognitive performance ranges from normal to an advanced degree of dementia. Most patients present an executive deficit, either in isolation or combined with other cognitive disorders, which is considered to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-08 00:00:00
abstract：INTRODUCTION:Valproic acid (VPA) is a drug mainly used to treat epilepsy. Hyperammonaemic encephalopathy due to VPA is a rare but serious complication. The mechanism by which VPA influences the increase in ammonia consists in blocking the urea cycle, thereby inhibiting N-acetylglutamate synthase and diminishing acetyl ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-11-01 00:00:00
abstract：TITLE:Actos reiterativos y ensayo-error. : ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:The modern history of the treatment of multiple sclerosis is reflected during the last years with the advent of controlled clinical trials design to produce measurable outcomes utilizing MRI techniques and statistical analysis. Addressing in this form the use of disease modifying medications: immunomodulation with int...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:In recent years, the non-motor symptoms of Parkinson's disease, including those of a psychiatric nature, have been receiving greater attention from the scientific community. DEVELOPMENT:In this paper we analyse the pathophysiological bases underlying the different psychiatric symptoms, examining the dopam...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:Developmental disorders are a common pathological condition in Neuropaediatrics and do not usually present characteristic anatomical alterations in the different neuroanatomical imaging tests that can be employed, such as computerised axial tomography or magnetic resonance (MR). Positron emission tomograph...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
