Abstract：
INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding the long-term efficacy and tolerability of LTG in refractory seizures. PATIENTS AND METHODS:We conducted a consecutive 10-year study of patients who began LTG therapy following poor control of their seizures, in spite of being treated with two or more antiepileptic drugs in monotherapy or in combination. Both their epidemiological and clinical data were collected for study. We studied the efficacy of the treatment, differentiating between remission (absence of seizures), improvement (reduction>50% of the seizures), inefficacy (reduction<50%), exacerbation (increase in seizures) and its tolerability (side effects and dropout). RESULTS:In all, data was collected from 39 patients, 18 males (46.2%), mean age 30.9 +/- 13.7 years; mean follow up time: 27.6 +/- 23.4 months. 43.7% presented cryptogenic epilepsy, in 28.5% it was symptomatic and in the remaining 28.5% it was idiopathic. EEG readings and neuroimaging scans were pathological in 53.8% and 43.6%, respectively. After beginning therapy with LTG, 33% remained free of seizures, 43.6% improved, in 18.3% it was seen to be ineffective and 5.1% got worse. Dropout rate was 56.4%:23.1% due to insufficient control over the seizures, 17.9% owing to side effects and 15.4% because of non-compliance. CONCLUSION:Treatment with LTG offers a high degree of efficacy in the control of seizures in patients with refractory epilepsy, although it is limited by a high dropout rate.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
García-Escrivà A,López-Hernández N,Alvarez-Saúco M,Pampliega-Pérez A,Oliver-Navarrete C,Asensio-Asensio M,Moltó-Jordá JM,Palao-Sánchez Asubject
Has Abstractpub_date
2004-02-16 00:00:00pages
301-3issue
4eissn
0210-0010issn
1576-6578pii
rn2003598journal_volume
38pub_type
杂志文章abstract：INTRODUCTION:The term «gossypiboma» comes from the Latin gossypium, which refers to a genus of cotton plants, and from the Swahili word boma, which translates as «place of concealment». It may be mistaken for tumorous lesions or abscesses due to the way it is encapsulated, as evidenced in imaging examinations, and its ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：10.33588/rn.6909.2019282
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Reported observations of acquired aphasia in children contain all the symptoms and syndromes that have been described in adult aphasiology. Recovery of colloquial language is good even if anomia and verbal memory deficits persist as the most frequent defects. At long term outcome there are ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To present a case with several cutaneous hemangiomas associated with intracranial hemangiomas and possibly with an intrahepatic hemangioma. CASE REPORT:A boy, 17 months old, showing several cutaneous hemangiomas and epileptic seizures resisting to antiepileptic medication, who also presented psychomotor reta...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：INTRODUCTION:The new 2015 criteria for neuromyelitis optica spectrum disorders (NMOSD) have been recently incorporated in the study of different international cohorts. AIM:To describe clinical-radiological characteristics and prognostic factors in patients with NMOSD according to the 2015 criteria. PATIENTS AND METHO...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
abstract：:The neuropathology of haemorrhagic and hypoxic-ischaemic perinatal encephalopathies and their effect on the post-natal development of the brain, has been studied in children who survived with these lesions (for days, weeks, months and even years). Eventually some children developed neurological sequelae, including epi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：INTRODUCTION:Perinatal asphyxia (PA) and its neurologic manifestations are the most important cause of brain injury and neurologic sequelae in full-term infants. The objective of this study is to analyze the perinatal risk factors of neurologic sequelae in asphyctic term newborns. PATIENTS AND METHODS:One hundred and ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：TITLE:Equivalente migrañoso de inicio tardío con aura prolongada y alteración de la perfusión cerebral. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.7011.2019333
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:Epilepsy is a chronic disease with high prevalence. Its impact in the quality of life is influenced by factors like disease characteristics, comorbidities, stigma perception and treatment adherence. AIM:To assess the quality of life, the social stigma and the treatment adherence of patients with epilepsy ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-10-16 00:00:00
abstract：:Despite the significant reduction in mortality, ischemic stroke is the leading cause of morbidity and mortality in adults in industrialized countries. Antiplatelet therapy has reduced the risk of stroke and other vascular events. Although most commonly used treatment is aspirin, other antiplatelet drugs with different...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Trigeminal neuralgia due to vertebrobasilar dolichoectasia is an acquired disease whose true incidence is not known. Microvascular decompression is the most effective technique both for symptomatic relief and for the conservation of nerve structure and function, in spite of the potential complications of a...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-04-16 00:00:00
abstract：INTRODUCTION:5% of patients with sarcoidosis are affected by neurological complications, of which myopathy is one of the least frequent. We report the clinical course and therapeutic response of two patients with sarcoid myopathy. CASE REPORTS:We observed two females aged 63 and 55 who were previously diagnosed with s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：INTRODUCTION AND METHOD:Dementia with Lewy bodies is a generative brain disease of unknown origin, characterised clinically by progressive mental deterioration, with striking fluctuations and transitory episodes of confusion, hallucinations and psychotic symptoms (hallucinations and paranoid deliria), extrapyramidal si...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-10-16 00:00:00
abstract：PATIENTS AND METHODS:Fifty patients diagnosed as having epileptic crises were given neuropsychological tests including the Wechsler Adult Intelligence Scale or WAIS, Luria's neuropsychological test and a quantitative EEG examination. Multivariate analysis was done of the following variables: presence or absence of inte...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:Magnetic resonance is the most sensitive para-clinical method available for the diagnosis of multiple sclerosis since it shows changes in 95% of the patients with clinically definite multiple sclerosis. However, little correlation has been found, in different studies, between the parameters of magnetic resonance and t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-16 00:00:00
abstract：INTRODUCTION:Rett's syndrome (RS) is a disorder of neurological development which is the second commonest cause of mental retardation in girls. It is normally caused by de novo mutations of a gene on the X chromosome. This gene encodes for the protein joining the methyl CpG (MECP2). Mutations of this gene have been fou...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:Fractures of the odontoid process make up between 10 and 15% of all cervical fractures. The decision as to when to operate on them is still controversial; the dilemma as to whether to use surgical or conservative treatment is still a problem. PATIENTS AND METHODS:We designed a descriptive study, which was...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Autism spectrum disorder (autism) is a highly prevalent and heterogeneous family of neurodevelopmental disorders of genetic origins with potentially devastating implications for child, family, health and educational systems. Despite advances in paper-and-pencil screening and in standardization of diagnostic procedures...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-02-25 00:00:00
abstract：TITLE:42.ª Reunion de la Sociedad de Neurofisiologia Clinica de las Comunidades de Valencia y Murcia. Comunicaciones. : ...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Alpha interferons (IFN a) have been shown to be effective in patients with chronic active hepatitis C. IFN a treatment may be associated with neurologic complications, including peripheral neuropathy. CASE REPORT:We describe a patient with active hepatitis C treated with IFN a, who developed peripheral ne...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-10-01 00:00:00
abstract：TITLE:Uso compasivo de cannabidiol en espray para el tratamiento de paraparesia espastica en un paciente con adrenomieloneuropatia. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:The risk of falls in older adults increases because of the decrease in strength, flexibility, balance and sensory changes affecting functionality and quality of life. For this reason, an integral system of evaluation of equilibrium is necessary, for preventive purposes or for early therapeutic intervention...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-11-16 00:00:00
abstract：INTRODUCTION AND METHOD:The issue regarding the relations between behaviour and the brain is no longer the specific goal of neuropsychology, but rather that of the coordinated multidisciplinary activity of all the disciplines that go to make up the neurosciences. The specific contribution of neuropsychology to this mul...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:Cerebrovascular accidents (CVA) are the third most common cause of death and are the main cause of permanent disability in the western world, where they also rank first as regards the loss of years of disability-adapted independent life. Ischaemic CVAs tend to present irreversible sequelae, which reduces t...
journal_title：Revista de neurologia
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:In neuropathic pain, as occurs in epilepsy, researchers are striving to find a drug capable of inhibiting the pain-generating ectopic discharges that are produced as a result of neuronal hyperexcitability. This is mediated by ionic exchanges across the channels of the synaptic membrane. This is why the dru...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:The paraneoplastic neurological syndromes are alterations associated with neoplasias. However, they are not caused by metastases or complications such as infections, vascular disorders, metabolic or nutritional alterations or secondary effect of treatment. The paraneoplastic syndromes are o...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-16 00:00:00
abstract：INTRODUCTION:Cystinosis is a hereditary disease with clinical symptoms that are caused by the accumulation of cystine crystals in different tissues. Distal vacuolar myopathy has been reported as one of its later complications. CASE REPORT:Here, we present the case of a 20-year-old male diagnosed with cystinosis at the...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Psychostimulant drugs encompass amphetamines, natural alkaloids like cocaine, and methyl-xanthynes. These drugs induce a strong dependence, manifested as sensitization and tolerance at a neurobiological level. Sensitization is currently being studied experimentally, and it is made up of two...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:The chronic inflammatory demyelinating polyneuropathy (CIDP) is a controversial sickness. No doubt it is still a diagnosis without a strict nosologic delimitation until we acquire a greater knowledge about the underlying mechanisms, or whether a specific marker is found. We evaluated its clin...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-04-16 00:00:00
abstract：AIM:To know the neural processes linked to the activity of brain circuits in order to understand the consequences of their dysfunction and their role in the development of neurodevelopmental diseases, such as autistic spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). DEVELOPMENT:The activit...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:The Real Ordinance 2070/1999 meant an important modification in the legislation, when including transcranial Doppler (TCD) in explorations to confirm the clinical diagnosis of brain death (BD). Habitually for their employment in the diagnosis of BD, we look for blood flow signal from the middle cerebral ar...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-11-16 00:00:00
