Abstract:
:The neuropathology of haemorrhagic and hypoxic-ischaemic perinatal encephalopathies and their effect on the post-natal development of the brain, has been studied in children who survived with these lesions (for days, weeks, months and even years). Eventually some children developed neurological sequelae, including epilepsy and cerebral palsy. In this paper it is emphasized that the post-natal development of the grey matter next to these lesions in altered in a specific manner. The post-natal resolution (scarring) of the subpial haemorrhage causes structural changes in the superficial layers of the cortex and permanent leptomeningial heterotopia. The pyramidal cell of layers II and III whose apical dendrites had been partially amputated by haemorrhage became star cells. The grey matter often survived an infarct of the subjacent white matter, since its circulation remained intact. However its post-natal development was altered in a specific way. The post-natal development of this grey matter (partly deprived of sensory information because of the destruction of afferent fibres and with contact lost because on the destruction of efferent fibres) is inevitably different. Projection pyramidal cells (long axon) axotomized by the subjacent lesion, survive the insult and post-natally are changed into intracortical short axon cells. The intrinsic neuropile of the grey matter (partially isolated) increases in an irregular manner which can be seen using immunohistochemical techniques and Golgi's method: areas with a great increase in fibres alternate with areas with few fibres. The presence of large neurones (Golgi's method) with long drendites covered with spines (acquired neuronal hypertrophy) is frequent. In this paper it is suggested that these changes in the grey matter secondary to subpial haemorrhage and hypoxic-ischaemic perinatal infarcts are accompanied by functional changes which may play and important role in the pathogenesis of epilepsy (infantile spasm) and in infantile cerebral palsy.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Marín-Padilla Msubject
Has Abstractpub_date
1997-05-01 00:00:00pages
673-82issue
141eissn
0210-0010issn
1576-6578journal_volume
25pub_type
杂志文章abstract:INTRODUCTION:Perinatal mortality has dropped markedly in recent years. However, there is still a considerable prevalence of neurological sequelas. Symptoms may present during the first months of life or later. Thus it is necessary to follow-up children with a clinical history of risk of neurological disorders. DEVELOP...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:This paper review current literature about neurocysticercosis with emphasis on recent advances on diagnosis and therapy. DEVELOPMENT:Cysticercosis is the most common parasitic disease of the nervous system. The disease occurs when humans become the intermediate host in the life cycle of Taenia solium by i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
abstract::X-linked adrenoleukodystrophy is the prototype of the disorders that involve a single peroxisomal protein, and it is by far the most common peroxisomal disorder. The gene that is defective in this disorder is a peroxisomal membrane protein involved, in an as yet undefined manner, in the degradation of very long chain ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:In all cases of young persons with clinical Parkinson s disease it should be suspected that it is secondary to some primary disorder. Therefore a battery of diagnostic tests should be done before classification as idiopathic Parkinson s disease. CLINICAL CASE:A 31 year old woman whose only previous illnes...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:INTRODUCTION:Advances in neuroimaging in the last decade have allowed a number of new findings about attention deficit hyperactivity disorder (ADHD) to be obtained. Quickly developing technology, together with the progress being made in genetics and neurochemical research, suggests a dysfunction of the fronto striatal ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-03-03 00:00:00
abstract:INTRODUCTION:Non epileptic paroxysmal events (NEPE) are clinical disorders of usually sudden appearance, brief and originated by a cerebral disfunction of diverse causes with a common character to be no epileptic. DEVELOPMENT:The non epileptic paroxysmal events are more frequent than epileptic events. The 10% of the c...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::It has been stated that findings in neonatal neurological examinations can play a role as a pointer to adverse developmental outcome. The description of the examinations, and their presence or absence differed among authors without clear reference to their physiological variability ranges. We approached the study of s...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:TITLE:Hemorragia vitrea bilateral asociada a hemorragia pontomesencefalica: un caso extremo de sindrome de Terson. : ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2018-07-15 00:00:00
abstract:INTRODUCTION:Epilepsy is a common disease with important social and economic repercussions. Patients with epilepsy have traditionally been discriminated by both the general population and physicians. A physician's lack of knowledge about epilepsy could be the cause of an incorrect clinical control (CC). AIMS:The purpo...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Preliminary studies (phase III) have shown that treatment with beta-interferon 1a (avonex) is effective in diverse aspects of relapsing/remitting multiple sclerosis (RRMS). The present study discusses results of an opened prolonged (phase IV) trial at the Baylor/Methodist International Multip...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:INTRODUCTION:Stroke is a leading cause of mortality and disability. Policosanol has been effective in brain ischemia models. The aim of this study is to investigate whether policosanol, added to aspirin therapy within 30 days of stroke onset, is better than placebo + aspirine for the long-term recovery of non-cardioemb...
journal_title:Revista de neurologia
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2017-02-16 00:00:00
abstract:INTRODUCTION:The term idiopathic T-CD4 lymphocytopenia is used to describe a new syndrome, defined as reduced T-CD4 lymphocytes in persons with no evidence of HIV infection or other causes which would explain the immunosuppression (secondary to neoplasties, immunosuppressive treatment, hereditary immunodeficiencies, in...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-02-16 00:00:00
abstract:INTRODUCTION:At the present time it is well established that cranial magnetic resonance (MR) is the imaging technique of choice for diagnosis of thrombosis of the dural sinuses. However, few studies have been done to evaluate its role in follow-up in this cerebrovascular disorder. OBJECTIVE:To assess the alterations i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract:INTRODUCTION:The cognitive effects of long-term exposure to organic solvents could be similar to those triggered by certain neurodegenerative diseases. AIMS:The purpose of this study was to evaluate the effects exerted by accumulated exposure on the cognitive functions. PATIENTS AND METHODS:105 subjects with an avera...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::The term 'acute myelopathies'--referred to a spinal cord dysfunction--represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. The objective of this review is to discuss the non-traumatic acute myelopathies. Acute myelopathy can be due to several causes as...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-06 00:00:00
abstract:INTRODUCTION:Epidemiological studies have demonstrated contradictory results about the association between smoking and the risk of Parkinson s disease (PD). OBJECTIVE:Examine the hypothesis of the EUROPARKINSON group that smoking protects against PD only in patients below 75 years of age. MATERIAL AND METHODS:We cond...
journal_title:Revista de neurologia
pub_type: 杂志文章,meta分析
doi:
更新日期:2003-03-16 00:00:00
abstract:INTRODUCTION:Stroke is a recognized cause of disability among adults. However the impact that the deficits that occur after a moderate/severe stroke have on long-term disability, as well as the response of the resultant deficits to rehabilitation, are not completely understood. PATIENTS AND METHODS:A total of 396 pati...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Cerebral vasculitis embraces a wide range of conditions that are characterised by involvement of the vessels of the central nervous system (CNS) due to inflammation of their walls, which in turn leads to occlusion or the formation of aneurysms with the ensuing ischaemic-haemorrhagic disorders this produces...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:Despite progress in understanding its pathogenesis, there has not yet been found any independent predictive marker of aggressive behavior of pituitary adenomas, to facilitate the treatment and monitoring of patients. AIM:To analyze the expression of folliculo-stellate cells by immunostaining with S-100 pr...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Statins represent a group of pharmaceutical agents with proven effectiveness and scarce side effects; however, their widespread use increases the probability of the appearance of such adverse effects. DEVELOPMENT:We reviewed the articles that have been published on myotoxicity, neurotoxicity and other cas...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Status epilepticus (SE) is the most common neurological emergency on pediatric. Given the possibility of neurological sequelae and mortality associated, it requires an early aggressive treatment. PATIENTS AND METHODS:Retrospective descriptive study based on the review of medical histories of patients admi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:In this research we study primary headaches, which are currently considered to be a public health problem. We also examine the fact that an ever increasing number of people are affected and that in some cases such headaches can eventually be disabling because they bring about different degrees of functiona...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-05-16 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:The chronic inflammatory demyelinating polyneuropathy (CIDP) is a controversial sickness. No doubt it is still a diagnosis without a strict nosologic delimitation until we acquire a greater knowledge about the underlying mechanisms, or whether a specific marker is found. We evaluated its clin...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-04-16 00:00:00
abstract:INTRODUCTION:Intracranial arterial aneurysms are little frequent among the pediatric age group but the frequency is still lower in children under 1 year of age and extremely rare in neonates. We present a case, review literature and propose common characteristics and management of this pathology. CASE REPORT:A term ne...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To carry out a bibliographic review of articles indexed in MEDLINE over the past 20 years concerning the pharmacological treatment of agitation in head injury. DEVELOPMENT:Head injury may cause different behaviour changes, of which agitation is the most dramatic. The incidence of agitation after severe head ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract:INTRODUCTION:The corpus callosum is the major neopallial connection between the two cerebral hemispheres. The corpus callosum agenesis (CCA) is found in 14% of CNS malformations. The diagnosis is based on neuroimaging procedures (ultrasonography, CT, MRI). The CCA is usually associated with facial dysmorphia, developme...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:Dysraphias are a varied set of anomalies affecting neuroectodermic tissue caused by the alteration of the neural tube during embryogenesis. Neuroradiological classification is broad and clinical manifestations are numerous: they affect the skin, osteomuscular tissue and the vascular, urological and nervous...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:TITLE:Meningoencefalitis tuberculosa con quistes aracnoideos medulares y siringomielia aguda. ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION:Vestibular evoked myogenic potential (VEMP) elicited by acoustic stimulation, has been proposed in the assessment of vestibulospinal pathways. AIM:To research the clinical utility of VEMP on multiple sclerosis (MS). SUBJECTS AND METHODS:Forty-four individuals were evaluated (30 normal state and 14 had MS...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2009-03-16 00:00:00
abstract:INTRODUCTION:The Aragon Stroke Care Plan (PAIA) was created in 2008 within the framework of the Spanish National Health System. Monitoring hospital care of strokes by means of periodic audits was defined as one of its lines of work. AIM:To determine the quality of the hospital care process for stroke patients in Arago...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-07-16 00:00:00