Abstract：
INTRODUCTION AND OBJECTIVE:Preliminary studies (phase III) have shown that treatment with beta-interferon 1a (avonex) is effective in diverse aspects of relapsing/remitting multiple sclerosis (RRMS). The present study discusses results of an opened prolonged (phase IV) trial at the Baylor/Methodist International Multiple Sclerosis Center using 6 MIU by intramuscular injection once a week. PATIENTS AND METHODS:Clinical measurements: EDSS and Patient's Subjective Self-Evaluation (PSSE) and magnetic resonance (MR) were utilized every three months in 300 patients studied between 1996-1999. Patients with RRMS (71.8%) and secondarily progressive multiple sclerosis (SPMS) (28.2%) were included. RESULTS:Global clinical improvement parameter integration was 22.7% and clinical stabilization 39.4%. MR did not show quantitative alterations for either group. Sixteen patients abandoned treatment and 16 (5.3%) had relapses correlated by MR activity; 34.9% remained stable by EDSS and magnetic resonance findings but deteriorated subjectively by PSSE (62% has SPMS). CONCLUSION:This phase IV study indicates that prolonged treatment of RRMS and SPMS with avonex maintains a positive effect in 62.1% of patients.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Rivera VMsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
470-1issue
5eissn
0210-0010issn
1576-6578journal_volume
31pub_type
杂志文章abstract：INTRODUCTION:In the last decades psychological studies have demonstrated the effectiveness of the cognitive-behavioural therapy for most anxiety and depressive disorders. Recently, a different and complementary approach in terms of validation of cognitive-behavioural therapy has emerged: testing the efficacy of these t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:In recent years, image techniques have transformed the diagnosis in Medicine. Nevertheless, they are, by now, far from a widespread clinic and surgical use. Beyond the simple picture inspection, DICOM digital files can be explored by using image analysis/processing techniques in a better way. In practice, clinicians a...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-10-16 00:00:00
abstract：INTRODUCTION:«Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinica...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：TITLE:Hematoma espinal extradural espontaneo. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:Sneddon syndrome is the association of livedo retricularis and cerebrovascular lesions. It is a vasculopathy of vessels of small and medium calibre which affects young people and is of unknown origin. It is often associated with arterial hypertension and repeated ischemic cerebrovascular accidents which le...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：INTRODUCTION:In recent years, significant advances have been made in the physiology and the pharmacology of vestibular disorders. It is now possible to elaborate an approximation of the mechanisms of action of the drugs used in the symptomatic treatment of vertigo. DEVELOPMENT:These drugs usually have a number of diff...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-16 00:00:00
abstract：INTRODUCTION:Posconcussional syndrome is characterized by a heterogeneous group of somatic, cognitive and psychosocial symptoms, which occur in patients with head trauma, generally of mild severity. It is the neuropsychiatric postraumatic disorder more prevalent in the field of forensic medicine. DEVELOPMENT:Classical...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
abstract：TITLE:Polimiositis secundaria a un linfoma no Hodgkin. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2017-04-01 00:00:00
abstract：INTRODUCTION:Several studies have reported alterations in the cerebrospinal fluid biomarkers (Abeta-42, T-tau and P-tau proteins), both in Alzheimer's disease (AD) and in mild cognitive impairment (MCI). AIM:To perform a meta-analysis of the diagnostic yield of this technique for the prediction of patients with MCI wh...
journal_title：Revista de neurologia
pub_type： 杂志文章,meta分析
doi：
更新日期：2010-02-16 00:00:00
abstract：AIM:To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain. PATIENTS AND METHODS:A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a fiv...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：TITLE:Encefalitis multifocal como manifestación neurológica de la infección por COVID-19. ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.7109.2020226
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:Face perception involves a broad network of connections between cortical and subcortical regions for the exchange and synchronization of information using white matter fibers. This precise communication system can be affected by the structures and the pathways that connect them. AIMS:To establish the neur...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:In this paper we review the main aetiologies of metabolic origin which cause epilepsy in children aged between 1 and 10 years. DEVELOPMENT:There are many aetiological causes of convulsive seizures. Seizures and epilepsies due to congenital errors of metabolism are a minority but should be known. Their identi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：INTRODUCTION:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV (HSAN IV) is a rare autosomal recessive disorder featuring recurrent fever episodes, inability to sweat, absent response to noxious stimuli, self mutilating behavior and mental retardation. It has...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-08-16 00:00:00
abstract：AIM:To evaluate the performance of patients with Alzheimer's disease (AD) in the mild-moderate stage in a verbal material abstraction task that involves interpreting the implicit meaning of proverbs and sayings. SUBJECTS AND METHODS:A qualitative-quantitative analysis was carried out of the performance of 30 patients ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:The possibility of diagnosing carotid stenosis and carrying out surgery without arteriography has increased with the use of different diagnostic methods. The eco-Doppler has been shown to be a useful method, although it requires previous individualised validation. OBJECTIVE:We aim to validate our Vascular...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：AIM:To analyze the safety profile and clinical outcome of patients with acute cerebral ischemia who received open treatment with tissue plasminogen activator (rt-PA) in a hospital without previous experience. PATIENTS AND METHODS:This prospective and observational study were realized from January 2004 to January 2007....
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown. Nevertheless, one of the most acceptable possibilities facing the origin of the tumor is the remaining rests of cere...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-16 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Deep brain stimulation (DBS) is a surgical technique based on the placement of a programmable electrode into certain areas of central nervous system. DBS is nowadays a well established treatment for patients with Parkinson's disease (PD) and motor complications. However, there are controver...
journal_title：Revista de neurologia
pub_type： 共识发展会议,杂志文章,实务指引
doi：
更新日期：2009-09-16 00:00:00
abstract：:Moya-Moya disease is an obstruction of the internal carotids and of the afferent and efferent channels of Willis's polygon, which causes a collateral circulation, responsible for the typical angiographic image of a "puff of smoke" (Moya-Moya, in Japanese). Its etiology is unknown, and it might be congenital or acquire...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：INTRODUCTION:Primary care professionals need useful and simple tools to detect early cognitive impairment in patients with any clinical suspicion of dementia. AIM. This critical review attempts to analyze the psychometric properties of cognitive screening tests, commonly used for screening dementia in primary care sett...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Hypnosis is a well known and efficient psychotherapeutic treatment. It has been stated as useful in memory improvement, however, there are only a few reports of this method in teaching, and its neurophysiological aspects. OBJECTIVE:In this paper, the authors were intended to deal with some students' acade...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:In recent years several authors have proposed that muscle pathological changes in humans with dystrophin disorders and in mdx-mice are the result of regeneration attempts of this tissue subjected to constantly repeated bouts of necrosis. AIM:We compared morphological aspects of degenerative-regenerative g...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-06-16 00:00:00
abstract：AIMS:We outline a proposal for the structural and functional features needed to develop a registry of dementias which can be used to collect standardised information that is both reliable and valid concerning cases of dementia in the specialised health care centres within a particular geographical area. DEVELOPMENT:Du...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:1. To critically analyze the concept of 'vegetative' state and a number of reasons that seem to justify the abandonment of this term. 2. To propose a new conceptual approach to the syndrome and, based on this approach, a new terminology. DEVELOPMENT:The concept of 'vegetative' state became popular in the me...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-12-16 00:00:00
abstract：INTRODUCTION:Purely bulbar hematomas are not common (0.25%-0.50% of all intraparenchymatous hematomas), probably because of the particular characteristics of the anatomy and hemodynamics of the bulbar circulation. CLINICAL CASES:We selected 18 cases. Three of these were our own and the purely bulbar localization was c...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION:In the evaluation of stenoses of the extracranial internal carotid artery (ICA), there are studies that suggest that magnetic resonance angiography (MRA) can be a substitute for conventional arteriography (CA), although it seems it has a tendency to overestimate the degree of stenosis. No similar compariso...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-10-16 00:00:00
abstract：INTRODUCTION:It is a well-known fact that a relatively high proportion of patients with essential tremor are resistant to a number of pharmaceuticals currently used to treat the condition. AIM:To assess the effectiveness and safety of levetiracetam (LEV) in patients who displayed little or no response or intolerable s...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:The processing of faces and recognition of familiar faces involves activity in many regions of the brain: 1. The visual association cortex in the act of constructing the perceived object; 2. Hippocampus and frontotemporal regions in the process of comparing what has been perceived with reme...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：INTRODUCTION:In the past, various studies have related chronic cocaine use to diverse types of neuropsychological impairment. However, the majority of these studies offer partial results using batteries of tests of little ecological weight. AIM:To investigate neuropsychological impairment (and of executive functions i...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-02-16 00:00:00
