Abstract:
INTRODUCTION:Stroke is a leading cause of mortality and disability. Policosanol has been effective in brain ischemia models. The aim of this study is to investigate whether policosanol, added to aspirin therapy within 30 days of stroke onset, is better than placebo + aspirine for the long-term recovery of non-cardioembolic ischemic stroke subjects. PATIENTS AND METHODS:Randomized, double-blind, placebo-controlled study. Eighty patients (mean age: 69 years) within 30 days of onset, with a modified Rankin Scale score (mRS) 2 to 4, were included. They were randomized in two groups (policosanol + aspirine or placebo + aspirine) for 12 months. RESULTS:Policosanol + aspirine decreased significantly mean mRS from the first interim check-up (1.5 months). The treatment even improved after long-term therapy. More policosanol + aspirin (87.5%) than placebo + aspirine (0%) patients achieved mRSs <= 1. Policosanol + aspirine increased significantly Barthel Index, lowered LDL-cholesterol and increased HDL-cholesterol versus placebo + aspirin. CONCLUSIONS:Long-term (12 months) administration of policosanol + aspirin given after suffering non-cardioembolic ischemic stroke was shown to be better than placebo + aspirin in improving functional outcomes when used among patients with non-cardioembolic ischemic stroke of moderate severity. TITLE:Efecto a largo plazo del policosanol en la recuperacion funcional de pacientes con ictus isquemico no cardioembolico: estudio de un año. :Introduccion. El ictus es una causa principal de mortalidad y discapacidad. El policosanol ha sido eficaz en modelos de isquemia cerebral. Este estudio investiga si el tratamiento a largo plazo con policosanol, añadido a la terapia con acido acetilsalicilico (AAS), dentro de los 30 dias posteriores a un ictus, es mejor que el placebo + AAS en la recuperacion de los pacientes. Pacientes y metodos. Estudio aleatorizado, doble ciego, controlado con placebo. Se incluyeron 80 pacientes (edad media: 69 años) que sufrieron un ictus en los 30 dias previos y con una puntuacion de 2-4 en la escala de Rankin modificada (mRS). Se distribuyeron aleatoriamente en dos grupos y recibieron policosanol + AAS o placebo + AAS durante 12 meses. Resultados. El tratamiento con policosanol + AAS disminuyo significativamente la puntuacion en la mRS desde el primer control intermedio (1,5 meses). El efecto del tratamiento incluso mejoro con la terapia a largo plazo. El numero de pacientes que alcanzaron valores de mRS menores o iguales a 1 fue superior en el grupo de policosanol + AAS (87,5%) que en el de placebo + AAS (0%). El tratamiento con policosanol + AAS aumento significativamente el indice de Barthel, disminuyo el colesterol LDL y aumento el colesterol HDL frente a placebo + AAS. Conclusiones. El tratamiento a largo plazo (12 meses) con policosanol + AAS fue mas efectivo que el tratamiento con placebo + AAS en la recuperacion funcional de los pacientes despues de sufrir un ictus isquemico no cardioembolico de moderada gravedad.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Sanchez J,Illnait J,Mas R,Mendoza S,Fernandez L,Mesa M,Vega H,Fernandez J,Reyes P,Ruiz Dsubject
Has Abstractpub_date
2017-02-16 00:00:00pages
153-161issue
4eissn
0210-0010issn
1576-6578pii
rn2016180journal_volume
64pub_type
杂志文章,随机对照试验abstract:INTRODUCTION:Both the normal and pathological development and involution of the CNS are regulated by an important set of both, 'growth factors' (inducing growth, differentiation, survival, adaptation or plasticity in neurons) and 'ageing factors' (inducing involution, atrophy, necrosis or apoptosis). In neurodegenerati...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract:INTRODUCTION:Cysticercosis remain an important health problem in developing countries. Its transmission is related to soil contamination with human feces. This parasitosis is found in Africa, Asia and Latin America, where the greatest incidences are seen in Mexico and Brazil. DEVELOPMENT:Human cysticercosis is acquire...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-08-16 00:00:00
abstract:INTRODUCTION:Based on medullary traction as responsible for idiopathic syringomyelia (SMI), idiopathic scoliosis (ESCID), Arnold Chiari malformation (ARCH), platybasia (PTB), basilar impression (IMB), odontoid recess (RTO) kinking of the brain stem (KTC) and considering the medullary traction to be transmitted by the f...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract:INTRODUCTION:The incidence of deep vein thrombosis and pulmonary embolism in patients with cerebral neoplasia has been estimated at 120/100,000 (the second highest rate for any kind of malignant neoplasia). A timely diagnosis is an indispensable requisite in the clinical evaluation of neurological patients. Patients su...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-11-01 00:00:00
abstract::By means of the modified trichromic method of Gomori, introduced by Engel and Cunningham in 1963 [1], it has been possible to demonstrate the presence of ragged-red fibers (RRF) in the mitochondrial myopathies. At present, to study these disorders in muscle biopsies, one may also use morphological, ultrastructural, hi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-01 00:00:00
abstract:INTRODUCTION:Clinical, electrophysiological, genetic and biochemical deficiencies variability were evaluated in 52 patients diagnosed of mitochondrial respiratory chain diseases (MRCD). PATIENTS AND METHODS:26 men and 26 women, aged 19 to 79 years, were tested by clinical examination, electrophysiological techniques, ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-10-16 00:00:00
abstract:INTRODUCTION:Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics. In spite of being a safe and effective anticonvulsant, VPA has been involved in the onset of changes in the metabolism of ammonia and carnitine, although few prospective studies have been made of this. OBJECTIVES:To evaluate the effe...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::The Landau-Kleffner syndrome consists of the association of paroxysmal EEG abnormalities, more marked during sleep, acquired aphasia usually of receptive type, and epileptic seizures in three quarters of cases. Additional features include behavioral disturbances that may even present with autistic features, cognitive ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-16 00:00:00
abstract::Neuromodulation for treating pain goes back to the times of the ancient Egyptians, who applied natural electric currents to modulate the painful sensation. Since then, this concept has been developed in parallel with the scientific and technological development, and various forms of neuromodulation with different indi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-12-01 00:00:00
abstract::In recent years, image techniques have transformed the diagnosis in Medicine. Nevertheless, they are, by now, far from a widespread clinic and surgical use. Beyond the simple picture inspection, DICOM digital files can be explored by using image analysis/processing techniques in a better way. In practice, clinicians a...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-10-16 00:00:00
abstract:INTRODUCTION AND METHOD:The issue regarding the relations between behaviour and the brain is no longer the specific goal of neuropsychology, but rather that of the coordinated multidisciplinary activity of all the disciplines that go to make up the neurosciences. The specific contribution of neuropsychology to this mul...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Face perception involves a broad network of connections between cortical and subcortical regions for the exchange and synchronization of information using white matter fibers. This precise communication system can be affected by the structures and the pathways that connect them. AIMS:To establish the neur...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Both cognitive psychology and neuropsychology require an approach to the multidimensional 'attention'. DEVELOPMENT:Attention permits behaviour to be suitable to the task in hand. According to the situation or activity required, the components or mechanisms of attention necessary vary (selectivity, alertne...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-03-01 00:00:00
abstract:INTRODUCTION:Traumatic brain injury (TBI) is a common cause of death and disability in the paediatric population, although the literature on the Spanish population is scarce. From the perspective of early vulnerability, recent research findings suggest that early brain injury has worse sequelae and a higher risk of imp...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:10.33588/rn.7007.2019393
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Functional hemispherectomy consists in palliative epilepsy surgical procedure usually performed in patients with pharmaco-resistant epilepsy and hemispheric syndromes. It is based on the neural disconnection of the affected hemisphere with preservation of the vascular supply. AIM:To analyze long-term prog...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2018-03-01 00:00:00
abstract::X-linked adrenoleukodystrophy is the prototype of the disorders that involve a single peroxisomal protein, and it is by far the most common peroxisomal disorder. The gene that is defective in this disorder is a peroxisomal membrane protein involved, in an as yet undefined manner, in the degradation of very long chain ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:According to the 1981 International League Against Epilepsy classification, absence seizures are the paradigm of idiopathic generalised seizures of childhood. Although absences are mainly of an idiopathic origin, there are also symptomatic absences, which account for 10% of all cases of absences. It is tho...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-09-16 00:00:00
abstract:INTRODUCTION:In recent years several authors have proposed that muscle pathological changes in humans with dystrophin disorders and in mdx-mice are the result of regeneration attempts of this tissue subjected to constantly repeated bouts of necrosis. AIM:We compared morphological aspects of degenerative-regenerative g...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-06-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Impairments in language and communication are a defining feature of autism spectrum disorders. There is significant variability in linguistic abilities in autism spectrum disorders. They have difficulties with certain aspects of language such as semantics functions, syntax, prosody and phon...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-03-03 00:00:00
abstract:TITLE:Consanguinidad y enfermedad mental grave en los primeros Borbones españoles. ...
journal_title:Revista de neurologia
pub_type: 评论,信件
doi:10.33588/rn.7108.2020438
更新日期:2020-10-16 00:00:00
abstract:INTRODUCTION:In clinical practice, it is common to find cases of epileptic women being treated with antiepileptic drugs (AEDs) whom we have to advise on the compatibility of these AEDs with breastfeeding. AIMS:In order to offer correct guidance, we must be well informed about the pharmacokinetic characteristics of the...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6902.2019037
更新日期:2019-07-16 00:00:00
abstract:TITLE:Analisis bibliometrico de las investigaciones españolas sobre neurorrehabilitacion en el ictus indizadas en Medline (2008-2017). : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.6811.2019070
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:The published data on neurological resources and the demand for neurological care in Spain were reviewed. Also, this demand was analysed in a specific health district (area 11, Hospital Universitario 12 de Octubre, Madrid). DEVELOPMENT:About 2.5 neurologists per 100,000 inhabitants in Spain was estimated to...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract:INTRODUCTION:The new 2015 criteria for neuromyelitis optica spectrum disorders (NMOSD) have been recently incorporated in the study of different international cohorts. AIM:To describe clinical-radiological characteristics and prognostic factors in patients with NMOSD according to the 2015 criteria. PATIENTS AND METHO...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To observe the frequency of various psychiatric disorders (depressive disorders, anxiety state and paraphrenic-paranoid disorders). PATIENTS AND METHODS:This study includes the 'cases' of dementia detected in an epidemiological field study done door-to-door, double phased and including non-institutionalized ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:TITLE:Signo del cerebelo blanco (reversal sign). : ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:It is a well-known fact that a relatively high proportion of patients with essential tremor are resistant to a number of pharmaceuticals currently used to treat the condition. AIM:To assess the effectiveness and safety of levetiracetam (LEV) in patients who displayed little or no response or intolerable s...
journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::Today, the fact that sensory integration difficulties with a neurological basis exist and that they seriously condition the development of those individuals who suffer from them is widely accepted and acknowledged as being obvious by the vast majority of professionals working in the field of community healthcare. Howe...
journal_title:Revista de neurologia
pub_type:
doi:
更新日期:2017-02-24 00:00:00
abstract:INTRODUCTION:Thymectomy is a surgical procedure which is generally accepted for treatment of myasthenia gravis. OBJECTIVE:To describe the long-term evolution of 217 myasthenic patients who had had thymectomies in the Hospital Clinico Quirurgico Hermanos Ameijeiras in La Habana, Cuba. PATIENTS AND METHODS:We determine...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::We report four young women with Takayasu's arteritis who developed an ischemic stroke. In three of these patients, this complication heralded the onset of the disease. Three patients also had seizures. In all cases, the diagnosis was suspected on the basis of an abnormal cardiovascular examination showing absent carot...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00