[The neurobiology of psychostimulant addiction].

Abstract:

INTRODUCTION AND DEVELOPMENT:Psychostimulant drugs encompass amphetamines, natural alkaloids like cocaine, and methyl-xanthynes. These drugs induce a strong dependence, manifested as sensitization and tolerance at a neurobiological level. Sensitization is currently being studied experimentally, and it is made up of two stages: initial induction and consolidated expression. During induction, the mesocorticolimbic circuit along with dopamine and glutamate changes in the ventral tegmentum play a critical role. During expression, addictive habits are consolidated through changes in the cortico-striato-amygdaloid loop. CONCLUSION:All together leads to a consolidated addiction, considered as an anomalous learning process, along with a loss of control over drug taking.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Fernández-Espejo E

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

147-54

issue

3

eissn

0210-0010

issn

1576-6578

pii

rn2005644

journal_volume

43

pub_type

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