Abstract：
INTRODUCTION:The endocannabinoid system consists of cannabinoid receptors, endogenous ligands and the enzymatic elements involved in their synthesis and breakdown. AIM:To report on currently held knowledge about the functioning of the system as a modulator of the neuroinflammatory processes associated with chronic diseases such as multiple sclerosis. DEVELOPMENT:Cannabinoids are synthesised and released on demand and their production increases in times of neuroinflammation and neural damage. In this context then, their actions in the microglial cells and in the astrocytes are characterised by a lowered expression of inflammatory mediators and pro-inflammatory cytokines. Furthermore, cannabinoids can play a role as neuroprotectors by means of different types of mechanisms and, in experimental models of multiple sclerosis, they slow down the symptoms, reduce inflammation and can favour remyelination. CONCLUSIONS:The clinical use of cannabinoids or pharmacological agents that affect the endogenous cannabinoid system during inflammation of the central nervous system and in multiple sclerosis is currently under consideration and subject to debate. Detailed analysis of the results obtained over the past decade has made it possible to establish the existence of several mechanisms of action of cannabinoids in pathologies affecting the central nervous system that are accompanied by chronic inflammation. Likewise, they also clearly show that the cannabinoid system is an interesting proposal as a new therapeutic tool.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Mestre L,Correa F,Docagne F,Clemente D,Ortega-Gutiérrez S,Arévalo-Martín A,Molina-Holgado E,Borrell J,Guaza Csubject
Has Abstractpub_date
2006-11-01 00:00:00pages
541-8issue
9eissn
0210-0010issn
1576-6578pii
rn2006259journal_volume
43pub_type
杂志文章,评审abstract：INTRODUCTION:Cerebral infarction (CI) can be classified aetiologically in several different ways using explicit diagnostic criteria. However, the extent to which these diagnostic criteria are actually implemented in clinical practice is unknown. Aims. The aim of this study was to analyse the management and use of diagn...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:Optic neuritis is rare in childhood. Frequently (35-52% of all cases depending on the series) they have, during their clinical course, foci of demyelination leading to the clinical picture of multiple sclerosis (MS). Since 1993, the optic neuritis study group has recommended treatment with high doses of co...
journal_title：Revista de neurologia
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doi：
更新日期：1999-05-01 00:00:00
abstract：INTRODUCTION:Statins represent a group of pharmaceutical agents with proven effectiveness and scarce side effects; however, their widespread use increases the probability of the appearance of such adverse effects. DEVELOPMENT:We reviewed the articles that have been published on myotoxicity, neurotoxicity and other cas...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-07-01 00:00:00
abstract：:The amygdala is related with the recognition of the emotional meaning of stimuli, long-term memory, the orientation of social stimuli and the perception of gaze orientation. It plays a fundamental role in the recognition of faces, especially those expressing fear, and makes it possible to comprehend different emotiona...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-24 00:00:00
abstract：INTRODUCTION:Status epilepticus (SE) is a condition in which epileptic discharges are sufficiently prolonged or repeated so as to cause persistent changes in neurological function. DEVELOPMENT:At the present time the classification of SE seems to be incomplete and therefore provisional. However the broad subdivision i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-08-01 00:00:00
abstract：INTRODUCTION:The corpus callosum is the major neopallial connection between the two cerebral hemispheres. The corpus callosum agenesis (CCA) is found in 14% of CNS malformations. The diagnosis is based on neuroimaging procedures (ultrasonography, CT, MRI). The CCA is usually associated with facial dysmorphia, developme...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT:Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-16 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：2000-06-16 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:The chronic inflammatory demyelinating polyneuropathy (CIDP) is a controversial sickness. No doubt it is still a diagnosis without a strict nosologic delimitation until we acquire a greater knowledge about the underlying mechanisms, or whether a specific marker is found. We evaluated its clin...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-04-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：2006-07-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
abstract：INTRODUCTION:The early years of life, more especially the first three, are dominated by a series of anatomical-functional facts that express the progressive enrichment of behaviour through the process of neurological maturation, which is expressed as reaching the maximum level of functioning at each stage of developmen...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-06 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2005-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-12-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-02-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：1997-12-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：2002-03-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7010.2019435
更新日期：2020-05-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-01 00:00:00
abstract：INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-16 00:00:00
