Abstract：
INTRODUCTION AND DEVELOPMENT:Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion load, although the total lesion load on T2-weighted MRI scans of the brain seems to be more relevant in determining frontal lobe deficits. Other non-conventional MRI techniques with a higher specificity to the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T1-weighted scans and the histogram analysis of magnetization transfer ratio maps, have recently been applied to MS cognitive studies. CONCLUSIONS:Results from these studies suggest that three factors play a role in the pathogenesis of MS dementia: the burden of MS lesions, the severity of the pathological damage within individual lesions and that of the normal-appearing white matter.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Filippi Msubject
Has Abstractpub_date
2000-06-16 00:00:00pages
1253-6issue
12eissn
0210-0010issn
1576-6578journal_volume
30pub_type
杂志文章abstract：INTRODUCTION:Lesions of the pyramidal system are characterized by their effects on qualitative aspects of movement. One of the features of pyramidal defects is the presence of associated movements or synkinesis. CLINICAL CASE:We present a case with residual associated electromyographic (EMG) response in a patient who ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:Cavernous angiomas are angiographically occult vascular malformations that are present in 0.4% of people, and represent 5 13% of all cerebrovascular malformations. They can be alone or multiple, and sporadic or familial. The presence of multiple lesions is more frequent in familial cavernomatosis. OBJECTI...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：INTRODUCTION:Throughout history a number of speculations have been put forward concerning the functional role of the pineal gland, perhaps some of the most important being the neurophysiological proposals by Descartes. DEVELOPMENT:The psychophysiological role conferred on the pineal gland by Descartes in the 17th cent...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2010-01-16 00:00:00
abstract：INTRODUCTION:Depression is a state of mind often associated with Parkinson's disease, which is not correlated with the stage of the disease or the response to treatment with L-dopa. It has been suggested that patients with right-sided Parkinsonism have more depression than those with left-sided. OBJECTIVE:To assess wh...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-12-16 00:00:00
abstract：INTRODUCTION:The epidemiology of multiple sclerosis (ME) in the Alcoi area has been studied by our groups for many years. When studying the factors linked to ME in this area initially we observed that migration, contact with dogs and the textile industry were associated with the disorder. A later study, in which the mi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：AIMS:The purpose of this work was to gather the information currently available about the content of nerve growth factor (NGF) in experimental models of neurodegeneration and in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, as well as to analyse how NGF content is affected by...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-16 00:00:00
abstract：INTRODUCTION:Cognitive dysfunction in mesial temporal lobe epilepsy (MTLE) is still a controversial subject. Since refractory MTLE is considered a surgically remediable syndrome, the neuropsychological assessment to establish the presence of cognitive impairment in the surgical candidate became an important issue, give...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-16 00:00:00
abstract：INTRODUCTION:Increased survival of patients with stroke, and reduction in the time spent in hospital, has led to more domiciliary care and extra problems of adjustment for the patient chronically disabled by the stroke and for his carer. MATERIAL AND METHODS:Ninety patient-carer units from the Stroke Unit of the Hospi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-16 00:00:00
abstract：INTRODUCTION:In the last years, the changes in glial cells during different alterations in the Central Nervous System have been studied. It is known that astrocytes and microglial cells are the glial cells which present the major reactivity. OBJECTIVE:The aim of this work was to analyze the glial cell changes induced ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：INTRODUCTION:Lamotrigine (LTG) is a new antiepileptic drug indicated in all kinds of partial and generalised clonic-tonic seizures, both in monotherapy and polytherapy. Between 20 and 30% of epileptic patients have poor control over their seizures despite adequate treatment. AIMS:We report on our experience regarding ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-16 00:00:00
abstract：INTRODUCTION:Numerous drugs have been related to exacerbation of myasthenia gravis. So far there are no studies examining the extent of use of drugs related to exacerbation of myasthenia gravis. AIMS:We sought to assess the extent of use of drugs related to exacerbations and the annual incidence rate of exacerbations ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7104.2020198
更新日期：2020-08-16 00:00:00
abstract：INTRODUCTION:Parkinson's disease (PD) is a common neurodegenerative disease which begins in adulthood. Its incidence in Mexico is estimated to be 40-50 cases per 100,000 inhabitants/year and is the fourth reason for medical care in the National Institute of Neurology and Neurosurgery. The protein alpha-synuclein, SNCA,...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-10-16 00:00:00
abstract：SUMMARY INTRODUCTION:Several different indigenous groups (Yamana, Selk'nam, Alacaluf, Haush) used to inhabit the Patagonian region of Tierra de Fuego, but are now extinct. AIM:To analyse the healing practices that these prehistoric aborigines used to treat headaches and to compare them with those observed in other ant...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:Several studies that has focused to the dopaminergic transmission in the basal ganglia in parkinsonian condition, but only a few article has taking into account the imbalance between dopaminergic and cholinergic transmission. OBJECTIVE:To evaluate the muscarinic cholinergic receptors density in SNc and PP...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-01-16 00:00:00
abstract：INTRODUCTION:FOXP2 is the first gene linked to a hereditary variant of specific language impairment and seems to code for a transcriptional repressor that intervenes in the regulation of the development and the functioning of certain thalamic-cortical-striatal circuits. DEVELOPMENT:In the last three years, significant...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-03-16 00:00:00
abstract：TITLE:Facilitar el acceso a toda la informacion debe ser una obligacion para las revistas medicas. : ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2018-02-16 00:00:00
abstract：INTRODUCTION:The subarachnoid haemorrhage non traumatic assumes between the 6-8% of all acute cerebrovascular, besides is more frequent in young persons. The mortility and mortality is high and the predictive factors of the worse prognostic in unknown. MATERIAL AND METHODS:In the present work, we realized a study of t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:At the present time the so-called parallel or next generation sequencing (NGS) technique is rapidly expanding and developing; this process establishes a jump by several orders of magnitude in the length of the fragments sequenced and the speed with which this sequencing is carried out. NGS allows a whole human genome ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:The diagnosis and treatment of posterior plagiocephaly is one of the most controversial aspects of craniofacial surgery. PATIENTS AND METHODS:The purpose of this study is to describe a recent increase in the incidence of occipital plagiocephaly without synostosis in our hospital during the last 6 months. ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：INTRODUCTION:Vascular lesions produced as a consequence of surgical spinal treatment are rare, but serious. Fast diagnosis and treatment are essential in lesions that produce massive blood loss. Following the use of non covered stents in the treatment of peripheral vascular stenotic obstructive pathologies, the appeara...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:We analyze the main factors influencing the time delay between onset and admission to the hospital in acute stroke. PATIENTS AND METHODS:Consecutive series of 1,344 patients with acute stroke or transient ischemic attack admitted at two reference hospitals of Valencia and included at the sam...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：INTRODUCTION:The early years of life, more especially the first three, are dominated by a series of anatomical-functional facts that express the progressive enrichment of behaviour through the process of neurological maturation, which is expressed as reaching the maximum level of functioning at each stage of developmen...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-06 00:00:00
abstract：INTRODUCTION:The term 'frontotemporal lobar dementia' (FTLD) covers a group of neurodegenerative diseases that are very heterogeneous in their clinical expression, genetic component and histopathological features, and this has traditionally made it difficult to study and classify them. Patients usually present a progre...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：:INTRODUCTION. Dystrophinopathies are X-linked genetic disorders caused by mutations in the DMD gene. Genetic tests are of utmost importance for management and genetic counseling of these diseases. However, the complexity of the DMD gene is a challenge for diagnosis. AIM. To describe recent advances in the diagnosis of...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-02-16 00:00:00
abstract：INTRODUCTION:Although the overall incidence of inborn errors of metabolism is low, their early diagnosis is essential, since some of them have a specific treatment. DEVELOPMENT:We review the main treatable inborn errors of metabolism that can present as early-onset epileptic encephalopathies, together with their bioch...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-05-17 00:00:00
abstract：INTRODUCTION:Early infantile epileptic encephalopathy (EIEE) with suppression burst activity in EEG (Ohtahara syndrome) is a rare type of epileptic encephalopathy in infancy and represents the earliest type of age-related symptomatic generalized epilepsy. The main etiologic factors associated to EIEE are cerebral dysge...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:The relationship between Chlamydia pneumoniae and atherosclerosis has been assessed in several studies. Development and conclusions. Their results suggest a possible role of Chlamydia pneumoniae in the origin and development of the disease, while the actual link between them are still unknown. However, the...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
abstract：INTRODUCTION:At the present time it is well established that cranial magnetic resonance (MR) is the imaging technique of choice for diagnosis of thrombosis of the dural sinuses. However, few studies have been done to evaluate its role in follow-up in this cerebrovascular disorder. OBJECTIVE:To assess the alterations i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:To review the mechanisms involved in the appearance of respiratory failure in patients with neuromuscular disorders. DEVELOPMENT:The development of respiratory failure in patients with weakness of the respiratory muscles secondary to neuromuscular disease is not only due to the disease itself. There are also...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
