Abstract：
AIMS:The purpose of this work was to gather the information currently available about the content of nerve growth factor (NGF) in experimental models of neurodegeneration and in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, as well as to analyse how NGF content is affected by the application of different neurorestorative therapies (transplant and trophic therapy) in these neurological entities. DEVELOPMENT:Neurotrophins are proteins that promote the differentiation, growth and survival of many populations of peripheral neurons and the central nervous system during development and adulthood. NGF is the best known and most widely researched member of this family, which is also made up of the growth factor derived from the brain and neurotrophins 3, 4/5, 6 and 7. In the last few decades, significant progress has been made in the knowledge available about the biological role played by these factors, their molecular characterisation and regulation, as well as their signalling mechanisms. Yet, little is known about the role played by the neurotrophic factors in neurodegenerative diseases or whether the levels of these factors are modified following the use of neurorestorative treatment. CONCLUSIONS:Neurodegenerative disorders, especially Parkinson and Alzheimer, are accompanied by modifications in the levels of NGF that depend on the extent to which the disease has progressed. A model of the changes in NGF content during neurodegenerative processes is also proposed.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Lorigados-Pedre L,Bergado-Rosado Jsubject
Has Abstractpub_date
2004-05-16 00:00:00pages
957-71issue
10eissn
0210-0010issn
1576-6578pii
rn2003174journal_volume
38pub_type
杂志文章,评审abstract：INTRODUCTION:Fingolimod is a selective immunosuppressant that targets the S1P receptor, and is indicated in the treatment of aggressive relapsing-remitting multiple sclerosis (RRMS) and following treatment failure with first-order drugs. AIM:To investigate the safety and effectiveness of fingolimod under the condition...
journal_title：Revista de neurologia
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更新日期：2017-05-16 00:00:00
abstract：INTRODUCTION:Status epilepticus (SE) is the most common neurological emergency on pediatric. Given the possibility of neurological sequelae and mortality associated, it requires an early aggressive treatment. PATIENTS AND METHODS:Retrospective descriptive study based on the review of medical histories of patients admi...
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更新日期：2015-05-01 00:00:00
abstract：:Two patients aged 52 and 31 respectively, treated for male infertility with gonadotrophins (LCG/LMG), showed marked improvement of their migraine crises associated with a typical aura which had been present since puberty. Changes in the number, motility and morphology of the spermatozoids were seen in the seminogram. ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
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更新日期：2001-04-16 00:00:00
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journal_title：Revista de neurologia
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更新日期：2002-09-16 00:00:00
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更新日期：2002-10-16 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2010-06-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2006-06-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
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更新日期：1996-12-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2004-04-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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更新日期：2018-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
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更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-05-16 00:00:00
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更新日期：2000-01-16 00:00:00
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更新日期：2009-04-16 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 信件,评审
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
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更新日期：1997-12-01 00:00:00
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更新日期：2014-03-16 00:00:00
