Abstract:
INTRODUCTION:The presence of muscarinic receptors on lymphocytes and possible modifications in their number and affinity may be related to cholinergic changes found in muscarinic receptors at a central level. OBJECTIVE:The objective of this paper is to bring the technique for the determination of lymphocyte muscarinic receptors by means of their union with radioligands for application in the study of disorders involving the cholinergic system, such as Alzheimer's disease, up to date. MATERIAL AND METHODS:We therefore made a density gradient isolation of lymphocytes from healthy subjects and made a trial of union or binding with N-methyl-escopolamine marked with tritium (3H-NMS) on intact lymphocytes. RESULTS:We were unable to specifically label the muscarinic receptors. However, we have shown the usefulness of the technique, using rat anterior cerebral homogenate. CONCLUSIONS:We consider whether the absence of specific union with the lymphocyte muscarinic receptor is due to technical problems as is often described in the literature, or possibly due to the absence of these receptors on the lymphocyte as suggested by other authors and proved using molecular biology techniques to be the case for the M2 receptor subtype.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Miralles F,Antem M,Matias-Guiu Jsubject
Has Abstractpub_date
1997-06-01 00:00:00pages
843-6issue
142eissn
0210-0010issn
1576-6578journal_volume
25pub_type
杂志文章abstract:INTRODUCTION:Episodes of recurrent bacterial meningitis can occur in patients due to either congenital or acquired disorders. Congenital deformity of the bony labyrinth can be linked to a fistulous tract communicating it with the intracranial subarachnoid space. Mondini deformity is a frequent malformation in congenita...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-11-16 00:00:00
abstract:OBJECTIVES:To review current knowledge regarding the mechanisms of action, pharmacokinetics, clinical efficacy and the tolerance of topirimate (TPM) and describe the Spanish experience of the use of this drug in 224 patients of all ages. DEVELOPMENT:TPM is a new drug which affects practically all the mechanisms involv...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
abstract::The appearance of involuntary movements in the clinical course of reflex sympathetic dystrophy (DSR) constitutes a rare clinical entity. In this context, the most frequent changes in movements are muscle spasms and focal dystonia, although postural tremor, muscle weakness and rhythmic myoclonus have also been describe...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:An arterial gas embolism is defined as the presence of air in the arterial circulation. This is an extremely rare cause of stroke that has been described in a multitude of clinical scenarios, generally related to iatrogenic processes. A clinical case is reported in which the arterial gas embolism occurred ...
journal_title:Revista de neurologia
pub_type:
doi:10.33588/rn.6903.2019178
更新日期:2019-08-01 00:00:00
abstract:AIM:To identify the clinical features that predict a favourable response to onabotulinumtoxinA (OnabotA) treatment in patients with refractory migraine. PATIENTS AND METHODS:Retrospective analysis of patients with refractory migraine who underwent at least two pericranial injections of OnabotA between 2008 and 2012. P...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-03-16 00:00:00
abstract::We studied 56 patients, 30 women and 26 men ranging from 30 to 79 years of age (average age 64.5 +/- 10.4), who were admitted to our hospital between 1982 and August 1995 with clinical features compatible with occlusion at the level of the bifurcation of the basilar artery. The patients were selected following clinica...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:The treatment of cervical spondylosis may be medical, surgical or both. Surgical treatment is indicated mainly in patients with untreatable pain, progressive neurological deficit and proven compression of the nerve roots and spinal cord. Corporectomy with a graft and fusion is one of the most widely used t...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Deep brain stimulation (DBS) is a surgical technique based on the placement of a programmable electrode into certain areas of central nervous system. DBS is nowadays a well established treatment for patients with Parkinson's disease (PD) and motor complications. However, there are controver...
journal_title:Revista de neurologia
pub_type: 共识发展会议,杂志文章,实务指引
doi:
更新日期:2009-09-16 00:00:00
abstract:INTRODUCTION:The development of scientific advances, constantly opening new frontiers of knowledge, leads to increasing complexity and specialization. DEVELOPMENT:The conflict between the never ending medical specialization and the opposite tendency, which is based mostly on economic grounds, prevents the acquisition ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:There is currently a growing interest for conducting studies into the electrical and neurochemical activity of the pedunculopontine nucleus (PPN) due to the privileged position occupied by this structure in the flow of information to and from the cortex. This nucleus acts as a relay, not only for the motor...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-16 00:00:00
abstract:INTRODUCTION:This paper review current literature about neurocysticercosis with emphasis on recent advances on diagnosis and therapy. DEVELOPMENT:Cysticercosis is the most common parasitic disease of the nervous system. The disease occurs when humans become the intermediate host in the life cycle of Taenia solium by i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:The processing of faces and recognition of familiar faces involves activity in many regions of the brain: 1. The visual association cortex in the act of constructing the perceived object; 2. Hippocampus and frontotemporal regions in the process of comparing what has been perceived with reme...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Disorders of movement in children frequently cause difficulties with both the semiology and the diagnostic approach. DEVELOPMENT:Based on our experience, we analyze useful strategies to overcome these difficulties and consider the clinical semiology, use of complementary tests and therapeutic approach. CONC...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-08-16 00:00:00
abstract:INTRODUCTION:Subacute sclerosing panencephalitis (SSPE) is a chronic neurodegenerative disease secondary to an infection of the central nervous system by the measles virus, with no effective treatment. The introduction of therapy with intraventricular interferon alpha (IFN-alpha) and its later association with ribaviri...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract:TITLE:Consanguinidad y enfermedad mental grave en los primeros Borbones españoles. ...
journal_title:Revista de neurologia
pub_type: 评论,信件
doi:10.33588/rn.7108.2020438
更新日期:2020-10-16 00:00:00
abstract:AIMS:The aim of this work was to study the cranial trepanations and deformations carried out by the ancient Paraca, Huari, Tiahuanaco and Inca cultures. To do so, we conducted a field study involving visits to archaeological remains and anthropological museums on the Andean plateau and the Peruvian coast. DEVELOPMENT:...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章
doi:
更新日期:2004-04-16 00:00:00
abstract:AIM:To evaluate the efficiency of topiramate (TPM), an antiepileptic medication (AEM) which possesses multiple mechanisms of action and good pharmacokinetics, in the different types of childhood epilepsy and to make an appraisal of its value in migraines, bipolar disorder, eating disorders and neuropathic pain, accordi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Sciatic nerve paralysis is a rare entity in the newborn. Few reference in specialized tests indicate that in the majority of cases the sciatic palsy has been observed after misplaced injections into the buttocks. The prognosis is variable and appears to be better after umbilical vessel catheterization for ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract:INTRODUCTION:Advances in neuroimaging in the last decade have allowed a number of new findings about attention deficit hyperactivity disorder (ADHD) to be obtained. Quickly developing technology, together with the progress being made in genetics and neurochemical research, suggests a dysfunction of the fronto striatal ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-03-03 00:00:00
abstract:PATIENTS AND METHODS:Fifty patients diagnosed as having epileptic crises were given neuropsychological tests including the Wechsler Adult Intelligence Scale or WAIS, Luria's neuropsychological test and a quantitative EEG examination. Multivariate analysis was done of the following variables: presence or absence of inte...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::Parkinson's disease is a neurodegenerative disorder associated with aging characterized by a motor extrapiramidal alteration secondary to the progressive death of dopaminergic neurons of the substantia nigra pars compacta. The cause of this neuronal loss remains unknown but post mortem studies on brains of parkinsonia...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-16 00:00:00
abstract:INTRODUCTION:Non-communicating hydrocephalus is defined as a blockade of the physiological cerebrospinal fluid (CSF) flow from the choroid plexus to the subarachnoid space. Usually, a ventricle peritoneal shunt with a valve is employed as treatment but this does not provide a physiological restoration on the CSF flow. ...
journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-02-15 00:00:00
abstract:INTRODUCTION:Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units. AIM:To evalu...
journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-10-16 00:00:00
abstract:INTRODUCTION:Examination of the special bilingual student (5% of the bilingual student population of the USA) permits us to use not only (1) the statistical reports of the population coefficients and percentages), (2) measurements of progress or performance (age in years or grades of progress at school) and (3) the neu...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:INTRODUCTION:The occupational environment generates a large amount of illness which involves several specialities, including neurology. However, there is little awareness--or little training--in this field as in most medical specialities, since in the basic tool of a doctor's work, the clinical history, importance is s...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract:INTRODUCTION:The motor control deficits after stroke affect the gait pattern. There is a significant variability between subjects. AIMS:To analyse, by using a capture motion system, the gait pattern in stroke patients with different levels of motor function, and to establish, despite the participants heterogeneity, wh...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-11-16 00:00:00
abstract:INTRODUCTION:Eosinophil infiltration of skeletal muscle is rare, but often no etiological factor can be identified and these are isolated eosinophilic myositis. They may be associated with parasite infections or drugs, or be features of rare systemic disorders of hypereosinophilia, such as the myalgia eosinophilia synd...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-11-16 00:00:00
abstract:INTRODUCTION:Perinatal mortality has dropped markedly in recent years. However, there is still a considerable prevalence of neurological sequelas. Symptoms may present during the first months of life or later. Thus it is necessary to follow-up children with a clinical history of risk of neurological disorders. DEVELOP...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:The damage caused to the central nervous system by lightning can be immediate or delayed. Cerebrovascular accidents are usually an infrequent complication of lightning strikes. CASE REPORT:We report the case of a patient who was hit by lightning and then developed an acute bilateral intraparenchymatous ha...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-16 00:00:00