Abstract：
INTRODUCTION:A number of genetic and neuroimagen proofs support the idea that attention-deficit/hyperactivity disorder (ADHD) present a neurobiological alteration. Vesicular monoamine transporters (VMATs) are important proteins that regulate the intraneuronal monoamine concentration and disposition as this protein sequesters cytoplasmic dopamine within synaptic vesicles thus contributing to subsequent excitotoxic release. DEVELOPMENT:Two pharmacologically distinct VMAT isoforms VMAT1 and VMAT2 have been cloned and described. The VMAT2, in the CNS, is responsible for the translocation of dopamine from the cytoplasm into synaptic vesicles. In addition, it has been described a neuroprotector role for these transporters. The platelet vesicular monoamine transporter VMAT2 is used as a peripheral model of neuronal VMAT2. Its quantification has been used to perform studies of ADHD and other neuropsychiatry diseases related with the monoamines metabolism. CONCLUSION:Since dopamine and other monoamines (epinephrine and serotonine) play a role in ADHD, and methylphenidate, an usual treatment for this type of patients, modifies the VMAT2 activity, we may argue that VMAT2 is involved in ADHD pathogeny.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Lorenzo-Sanz G,Sánchez-Herranz Asubject
Has Abstractpub_date
2011-03-01 00:00:00pages
S103-8eissn
0210-0010issn
1576-6578pii
rn2011058journal_volume
52 Suppl 1pub_type
杂志文章,评审abstract：INTRODUCTION:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV (HSAN IV) is a rare autosomal recessive disorder featuring recurrent fever episodes, inability to sweat, absent response to noxious stimuli, self mutilating behavior and mental retardation. It has...
journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2005-08-16 00:00:00
abstract：AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...
journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
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更新日期：2002-10-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-08 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-07-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:The aim of the study was the short term test-retest-reliability of electrophyisiological correlates of simple processes of the motor control, i.e. the execution (go) and the inhibition (no go) of a prepared motor response, evoked during the Continuous Performance Test (CPT). Our interest was centered in the ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-27 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-12-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Transcranial Doppler (TCD) is a new technique which is becoming increasingly used in neurology and is highly dependent on the user. OBJECTIVE:To evaluate the reliability of TCD in our hospital. PATIENTS AND METHODS:During a five month period, all patients who had a cerebral angiogram done, also had DTC w...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-09-16 00:00:00
abstract：INTRODUCTION:Alpha interferons (IFN a) have been shown to be effective in patients with chronic active hepatitis C. IFN a treatment may be associated with neurologic complications, including peripheral neuropathy. CASE REPORT:We describe a patient with active hepatitis C treated with IFN a, who developed peripheral ne...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-11-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-01-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-11-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-07-15 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-15 00:00:00
