[Involvement of vesicular monoamine transporter in attention deficit hyperactivity disorder].

Abstract:

INTRODUCTION:A number of genetic and neuroimagen proofs support the idea that attention-deficit/hyperactivity disorder (ADHD) present a neurobiological alteration. Vesicular monoamine transporters (VMATs) are important proteins that regulate the intraneuronal monoamine concentration and disposition as this protein sequesters cytoplasmic dopamine within synaptic vesicles thus contributing to subsequent excitotoxic release. DEVELOPMENT:Two pharmacologically distinct VMAT isoforms VMAT1 and VMAT2 have been cloned and described. The VMAT2, in the CNS, is responsible for the translocation of dopamine from the cytoplasm into synaptic vesicles. In addition, it has been described a neuroprotector role for these transporters. The platelet vesicular monoamine transporter VMAT2 is used as a peripheral model of neuronal VMAT2. Its quantification has been used to perform studies of ADHD and other neuropsychiatry diseases related with the monoamines metabolism. CONCLUSION:Since dopamine and other monoamines (epinephrine and serotonine) play a role in ADHD, and methylphenidate, an usual treatment for this type of patients, modifies the VMAT2 activity, we may argue that VMAT2 is involved in ADHD pathogeny.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Lorenzo-Sanz G,Sánchez-Herranz A

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

S103-8

eissn

0210-0010

issn

1576-6578

pii

rn2011058

journal_volume

52 Suppl 1

pub_type

杂志文章,评审
  • [Improvements in the symptoms of olivopontocerebellar atrophy with gabapentin].

    abstract:INTRODUCTION:Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrosp...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Gazulla J,Benavente MI

    更新日期:2005-03-01 00:00:00

  • [Isolated girdle weakness: expansion of the phenotypic spectrum of the MERRF 8344A>G mutation of mitochondrial DNA].

    abstract:INTRODUCTION:The differential diagnosis of diseases that are accompanied by adult-onset girdle weakness is broad and includes motor neurone, neuromuscular junction or muscular diseases. The 8344A>G mutation of the MTTK gene of mitochondrial DNA usually presents with involvement of multiple organs associated (or not) wi...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Erdocia-Goni A,Alonso-Jimenez A,Ramon-Carbajo C,Garcia-Arumi E,Casquero P,Gallardo E,Diaz-Manera J

    更新日期:2018-04-16 00:00:00

  • [Status epilepticus in paediatrics: a retrospective study and review of the literature].

    abstract:INTRODUCTION:Status epilepticus (SE) is the most common neurological emergency on pediatric. Given the possibility of neurological sequelae and mortality associated, it requires an early aggressive treatment. PATIENTS AND METHODS:Retrospective descriptive study based on the review of medical histories of patients admi...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Moreno-Medinilla EE,Negrillo-Ruano R,Calvo-Medina R,Mora-Ramírez MD,Martínez-Antón JL

    更新日期:2015-05-01 00:00:00

  • [A descriptive analysis of the demand for ambulatory neurological care in the health district of Huelva].

    abstract:INTRODUCTION:In recent years the demand for ambulatory neurological care has risen. Studying this situation can help to improve health care planning and the quality of the referrals from primary care. AIM:To analyse a number of variables involved in the first visits referred from primary care to neurology services. P...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: López-Domínguez JM,Rojas-Marcos I,Sanz-Fernández G,Blanco-Ollero A,Robledo-Strauss A,Díaz-Espejo C

    更新日期:2007-05-01 00:00:00

  • [Thoracic outlet syndromes].

    abstract:INTRODUCTION:The thoracic outlet syndromes are clinical conditions whose true incidence is low, although they are frequently diagnosed. They are caused by compression of the brachial plexus or vascular structures due to anatomical anomalies of the cervico-axillary region. DEVELOPMENT:Two main types are seen: the neuro...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Molina-Martínez FJ,Calles-Hernández MC

    更新日期:1998-07-01 00:00:00

  • [Microvascular decompression of trigeminal neuralgia caused by vertebrobasilar dolichoectasia].

    abstract:INTRODUCTION:Trigeminal neuralgia due to vertebrobasilar dolichoectasia is an acquired disease whose true incidence is not known. Microvascular decompression is the most effective technique both for symptomatic relief and for the conservation of nerve structure and function, in spite of the potential complications of a...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: García De Sola R,Escosa Bagé M

    更新日期:2001-04-16 00:00:00

  • [The diagnostic evaluation and therapeutic basis of immediate release methylphenidate in attention deficit hyperactivity disorder].

    abstract:INTRODUCTION:Attention deficit disorder with or without hyperactivity (ADHD) is characterised by the patients' inability to pay attention in non selective activities, hyperactivity that is difficult to inhibit, impulsiveness with failure to control their reactions and an unstable personality, which gives rise to diffic...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Valdizán JR

    更新日期:2004-03-16 00:00:00

  • [Modifiable risk factors for non-cardioembolic transient ischemic attacks. Case control studies in the general population].

    abstract:INTRODUCTION:Transient ischemic attacks (TIA) often precede a stroke. AIMS:The purpose of this study is to examine the modifiable cardiovascular risk factors for non-cardioembolic TIA. PATIENTS AND METHODS:A population based case control study was conducted in a district within the city of Barcelona. The cases were 1...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Baena-Diéz JM,Tomàs-Pelegrina J,Merino-Audi M,Arboix A,Ellacuría-Torres A,García-Lareo M,Liste-Salvador V

    更新日期:2003-08-01 00:00:00

  • [Delayed hospitalization of the patient with acute stroke].

    abstract:INTRODUCTION AND OBJECTIVE:We analyze the main factors influencing the time delay between onset and admission to the hospital in acute stroke. PATIENTS AND METHODS:Consecutive series of 1,344 patients with acute stroke or transient ischemic attack admitted at two reference hospitals of Valencia and included at the sam...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Geffner D,Lago A,Tembl J,Vilar C

    更新日期:1998-12-01 00:00:00

  • [The epidemiology of multiples sclerosis in Alcoi. Analytical data].

    abstract:INTRODUCTION:The epidemiology of multiple sclerosis (ME) in the Alcoi area has been studied by our groups for many years. When studying the factors linked to ME in this area initially we observed that migration, contact with dogs and the textile industry were associated with the disorder. A later study, in which the mi...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Frutos Alegría MT,Beltrán-Blasco I,Quilez-Iborra C,Moltó-Jordá J,Díaz-Marín C,Matías-Guiu J

    更新日期:2002-05-01 00:00:00

  • [A patient with bilateral lesion in the striatum and slowly progressive dystonia secondary to T14487C mutation in the ND6 gene of complex I of the mitochondrial respiratory chain].

    abstract:INTRODUCTION:A large number of diseases present as bilateral striatal lesion syndrome (BSLS). Clinical manifestations, course and prognosis of these diseases are extremely variable. On the basis of their evolutive course, they can be separated into two major groups: acute, which include toxic, infectious or parainfecti...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Raspall-Chaure M,Solano A,Vázquez E,Macaya-Ruiz A,del Toro-Riera M,Cabezuelo-Briones A,Montoya J,Andreu A,Roig-Quilis M

    更新日期:2004-12-16 00:00:00

  • [Cerebral palsy: prenatal risk factors].

    abstract::Prenatal risk factors causing cerebral palsy (CP), here defined as a non-progressive motor abnormality of tone or posture, are much more numerous than once believed, when a great deal of brain injury was attributed to factors surrounding delivery. Scientific advances in genetics and biochemistry, as well as clinical t...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Pascual JM,Koenigsberger MR

    更新日期:2003-08-01 00:00:00

  • [Treatment with antisense oligonucleotides in Duchenne's disease].

    abstract::In this paper I review the results of the treatments directed to modify the mRNA of dystrophin with the goal of converting the severe Duchenne type to the milder Becker muscular dystrophy. Antisense oligomers potential to modify Duchenne muscular dystrophy (DMD) gene expression and therapeutic strategies to induce rib...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Pascual-Pascual SI

    更新日期:2012-05-21 00:00:00

  • [Combination of new electrophysiological and imaging techniques in the study of primary visual cortex function].

    abstract:INTRODUCTION:This work summarizes current research focused on explaining orientation selectivity of primary visual cortex (V1), and describes the electrophysiological and imaging techniques than are being used. DEVELOPMENT:The study of orientation selectivity in V1 is key to understanding the cortical mechanisms impli...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Mariño J,Schummers J,Sur M

    更新日期:2003-05-16 00:00:00

  • [Dissection of the internal carotid artery with subarachnoid hemorrhage].

    abstract:INTRODUCTION:Dissection of the intracranial arteries is uncommon, forming less than 10% of all cranio-cervical dissections. Apart from the classical clinical findings of extracranial dissections, intracranial dissection may cause subarachnoid haemorrhage (SAH), mainly dissections involving the posterior circulation. C...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Martín-Bermúdez R,Arenas-Cabrera C,Gil-Néciga E,Jarrín S

    更新日期:1997-06-01 00:00:00

  • [Glutaric aciduria type I. Clinical, biochemical and molecular findings in six patients in Venezuela].

    abstract:INTRODUCTION:Glutaric aciduria type I is an autosomal recessive inborn error of metabolism that is due to a deficiency of the enzyme glutaryl-CoA dehydrogenase, which gives rise to an accumulation of glutaric and 3-hydroxyglutaric acids in biological fluids. Clinical features present as a sudden-onset severe neurologic...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Mahfoud A,Domínguez CL,Rizzo C,García-Villoria J,Navarro-Sastre A,Ribes A

    更新日期:2007-05-16 00:00:00

  • [HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system].

    abstract::Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Merino JJ,Montes ML,Blanco A,Bustos MJ,Oreja-Guevara C,Bayon C,Cuadrado A,Lubrini G,Cambron I,Munoz A,Cebolla S,Gutierrez-Fernandez M,Bernardino JI,Arribas JR,Fiala M

    更新日期:2011-01-16 00:00:00

  • [Trident sign in spinal cord neurosarcoidosis].

    abstract:TITLE:Signo del tridente en la neurosarcoidosis medular. : ...

    journal_title:Revista de neurologia

    pub_type:

    doi:10.33588/rn.7005.2019180

    authors: Bala M,Saucedo M,Bandeo L,Chertcoff A,Uribe-Roca C,Bonardo P,Fernández-Pardal M,Miquelini L,Méndez J,Reisin R

    更新日期:2020-03-01 00:00:00

  • [First tonic clonic generalized seizure: recurrence, and prognosis factors].

    abstract:OBJECTIVE:Previous epidemiologic studies have shown that around 5% of the population will suffer a tonic clonic seizure during their life. The aim of this study is to know how many and which of these people will suffer a second seizure and become epileptic. PATIENTS AND METHODS:175 patients seen in the emergency depar...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Falip-Centellas M,Rovira RM,Gratacós-Vinyola M,Lluís C,Pérez-Pérez S,Padró-Ubeda L

    更新日期:2002-05-16 00:00:00

  • [Non-speech oral motor treatment efficacy for children with developmental speech sound disorders].

    abstract:INTRODUCTION:In the treatment of speech disorders by means of speech therapy two antagonistic methodological approaches are applied: non-verbal ones, based on oral motor exercises (OME), and verbal ones, which are based on speech processing tasks with syllables, phonemes and words. In Spain, OME programmes are called '...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Ygual-Fernandez A,Cervera-Merida JF

    更新日期:2016-01-01 00:00:00

  • [XV Reunion Anual de la Asociacion Madrilena de Neurologia. Communications].

    abstract:TITLE:XV Reunion Anual de la Asociacion Madrilena de Neurologia. Comunicaciones. : ...

    journal_title:Revista de neurologia

    pub_type:

    doi:

    authors:

    更新日期:2017-12-16 00:00:00

  • [Intracranial arachnoid cysts. A study of a series of 35 cases].

    abstract:INTRODUCTION:Arachnoid cysts are cavities with a content similar to cerebrospinal fluid, frequently communicating with the subarachnoid space. They make up 1% of the intracranial space occupying lesions, and although typically seen in children (13%), they may be undiagnosed until the patient has become adult. PATIENTS...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Gómez Escalonilla CI,García Morales I,Galán Dávila L,Giménez-Torres MJ,Simón-Heras R,Valencia J,Mateos-Beato F

    更新日期:2001-08-16 00:00:00

  • [Polycystic ovary syndrome and valproic acid].

    abstract:INTRODUCTION:The reproductive functions of epileptic females often display alterations. This dysfunction can be due to psychological, physiological or pharmacological factors. These women have been described as having, for example, a higher incidence of anovulatory cycles, infertility, alterations affecting the hypotha...

    journal_title:Revista de neurologia

    pub_type: 杂志文章,评审

    doi:

    authors: Ribacoba Montero R,Martínez-Faedo C,Salas-Puig J

    更新日期:2003-11-16 00:00:00

  • [Cerebral malaria in children].

    abstract:INTRODUCTION:Malaria is one of the main health problems in the Third World. Plasmodium falciparum infects as many as 300 million people, causing up to three million deaths each year, most of which occur in African children. Cerebral malaria is the most common lethal complication of P. falciparum infection in children a...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: García-Peñas JJ,Quintero V,Gutiérrez-Solana LG,Ruiz-Falcó ML

    更新日期:2000-01-01 00:00:00

  • [Deciding on treatment in multiple sclerosis].

    abstract::The modern history of the treatment of multiple sclerosis is reflected during the last years with the advent of controlled clinical trials design to produce measurable outcomes utilizing MRI techniques and statistical analysis. Addressing in this form the use of disease modifying medications: immunomodulation with int...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Rivera VM

    更新日期:2003-01-01 00:00:00

  • [Hyperperfusion syndrome as a complication of percutaneous transluminal angioplasty of the internal carotid artery].

    abstract:INTRODUCTION:The hyperperfusion syndrome (HS) is described as an infrequent complication of carotid endarterectomy. It may also occur in percutaneous transluminal carotid angioplasty with a similar causal mechanism and clinical features to those seen in HS related to carotid endarterectomy. CLINICAL CASE:We describe t...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: González A,Mayol A,Gil-Peralta A,González-Marcos JR,Boza F,Ruano J

    更新日期:1999-11-16 00:00:00

  • [SARS-CoV-2, a new causal agent of Guillain-Barre syndrome].

    abstract:TITLE:SARS-CoV-2, nuevo agente causal del síndrome de Guillain-Barré. ...

    journal_title:Revista de neurologia

    pub_type: 信件

    doi:10.33588/rn.7107.2020264

    authors: Redondo-Urda MJ,Rodríguez-Peguero FJ,Pérez-Gil O,Del Valle-Sánchez M,Carrera-Izquierdo M

    更新日期:2020-10-01 00:00:00

  • [Central nervous system infection by free-living amebas: report of 3 Venezuelan cases].

    abstract:INTRODUCTION:Infection of the Central Nervous System by free living amebas is an unusual event, 344 cases have been reported to date. The disease becomes evident in two different clinical fashions: Primary Amebic Meningoencephalitis (PAM) caused by Naegleria fowleri and Granulomatous Amebic Encephalitis (GAE) induced b...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Rodríguez R,Méndez O,Molina O,Luzardo G,Martínez AJ,Visvesvara GS,Cardozo J

    更新日期:1998-06-01 00:00:00

  • [Clinical assessment of attention deficit hyperactivity disorder, interview model and controversial issues].

    abstract:INTRODUCTION:Attention deficit hyperactivity disorder (ADHD) is one of the most frequent reasons for visits to neuropaediatric services. Although the clinical criteria are well established, the medical history is probably not examined with enough care and the most decisive symptoms go unnoticed. AIM. To review a clinic...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Vaquerizo-Madrid J

    更新日期:2008-01-01 00:00:00

  • [Clinical and neuropathological study of two brothers with Cockayne syndrome].

    abstract:INTRODUCTION:Cockayne syndrome (CS) is a rare autosomal recessive disease which is characterized by physical and mental retardation, progressive neurological disfunction, photosensitivity and other cutaneous features. Usually they present ophthalmologic abnormalities as well as other heterogenous clinical, radiological...

    journal_title:Revista de neurologia

    pub_type: 杂志文章

    doi:

    authors: Olaciregui O,Yoldi ME,Gurtubay IG,García-Bragado F,Carrera B,Gila L,Morales G

    更新日期:2001-10-01 00:00:00