Abstract:
AIM:To analyze the importance of the neurotransmitter glutamate in the pathogenesis of Alzheimer's disease (AD). DEVELOPMENT:Elements of the physiological glutamatergic neurotransmission are reviewed, such as the neuronal types that utilize it, glutamatergic receptors and their characteristics, and glutamate transporters that remove this amino acid from the synaptic cleft. Some aspects of AD neuropathology changes in the brain content of glutamate, and other changes in the different types of glutamatergic receptors and transporters are also examined. A mechanism of disease related to prolonged exposure to glutamate, known as 'slow or indirect excitotoxicity', peculiar to some neurodegenerative diseases, is analyzed, as are the causes that may unleash it in AD. Some of the neuropathologic findings in this disease may be related to the glutamatergic dysfunction. CONCLUSION:Glutamatergic dysfunction plays an important role in the pathogenesis of this illness, although this disturbance is probably a secondary phenomenon to other neurochemical, genetic or metabolic changes, essential to the development of AD.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Gazulla J,Cavero-Nagore Msubject
Has Abstractpub_date
2006-04-01 00:00:00pages
427-32issue
7eissn
0210-0010issn
1576-6578pii
rn2005223journal_volume
42pub_type
杂志文章,评审abstract::The new insights presented at the 5th Joint Triennial Congress of the European and Americas Committees on Treatment and Research in Multiple Sclerosis (ECTRIMS and ACTRIMS) held in Amsterdam, the Netherlands, 19-22 October 2011, have been summarized at the fourth edition of Post-ECTRIMS meeting held in Madrid in Novem...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2012-06-16 00:00:00
abstract:INTRODUCTION:Stroke is a serious but potentially reversible entity. Reducing the time of care in the acute phase is essential to limit morbidity and mortality. The evaluation of the performances in stroke care is essential because it allows identify opportunities for improvement. AIM:To understand and analyze the dete...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-02-16 00:00:00
abstract:INTRODUCTION:Aseptic meningitis is a process that is characterised by an inflammatory reaction of the meninges that is not due to any infectious agent. Its aetiology is varied and is most frequently caused by rheumatologic and/or autoimmune processes, chemical or medication-induced meningitis, the most notable drugs in...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2006-02-16 00:00:00
abstract:OBJECTIVES:To review current literature on population, cytogenetic and molecular studies of specific language disorders (SLD) and pervasive developmental disorders (PDD). DEVELOPMENT:Clinical concordance studies in twins and in vertical familial groups suggest polygenic multifactorial modes of inheritance, but in some...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:Multiple sclerosis is a demyelinating neurological disease that usually gives rise to motor, perceptive, affective and cognitive disorders in patients. These symptoms can lead the person to lose his or her job and lower the quality of life of both patients and their relatives. AIM:To review the literature...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown. Nevertheless, one of the most acceptable possibilities facing the origin of the tumor is the remaining rests of cere...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-08-16 00:00:00
abstract:INTRODUCTION:Perinatal asphyxia (PA) and its neurologic manifestations are the most important cause of brain injury and neurologic sequelae in full-term infants. The objective of this study is to analyze the perinatal risk factors of neurologic sequelae in asphyctic term newborns. PATIENTS AND METHODS:One hundred and ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::INTRODUCTION. A large number of neurological diseases course with impairment of higher cognitive functions, their evaluation being important for diagnostic, prognostic and therapeutic purposes. The main purpose of neuropsychological assessment is to identify behavioral, emotional and cognitive consequences of brain dy...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-12-16 00:00:00
abstract:INTRODUCTION:Non-communicating hydrocephalus is defined as a blockade of the physiological cerebrospinal fluid (CSF) flow from the choroid plexus to the subarachnoid space. Usually, a ventricle peritoneal shunt with a valve is employed as treatment but this does not provide a physiological restoration on the CSF flow. ...
journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:INTRODUCTION:From time to time the debate over whether early-onset epileptic seizures are harmless or have harmful effects on the developing brain reappears. DEVELOPMENT:We evaluated the results of clinical studies reporting the long-term cognitive development of children who suffer from early-onset epilepsies, that i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2007-05-21 00:00:00
abstract:INTRODUCTION:This paper review current literature about neurocysticercosis with emphasis on recent advances on diagnosis and therapy. DEVELOPMENT:Cysticercosis is the most common parasitic disease of the nervous system. The disease occurs when humans become the intermediate host in the life cycle of Taenia solium by i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:Autism spectrum disorders (ASD) are neurodevelopmental disorders that affect social communication and present stereotypic behaviours. Comorbidity associated to conduct disorders is frequent, starts in infancy and, in general, continues into adulthood. It is sometimes associated with aggressiveness, negativ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2018-03-01 00:00:00
abstract:TITLE:Disfunción de barrera y síndrome de Guillain-Barré como exponentes del daño endotelial en la COVID-19. ...
journal_title:Revista de neurologia
pub_type: 评论,信件
doi:10.33588/rn.7111.2020568
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:The processing of faces and recognition of familiar faces involves activity in many regions of the brain: 1. The visual association cortex in the act of constructing the perceived object; 2. Hippocampus and frontotemporal regions in the process of comparing what has been perceived with reme...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION:Most patients with Parkinson's disease have cognitive and behavior disorders during the course of their illness. OBJECTIVE:In this study we consider practical aspects of the treatment of patients with Parkinson's disease who have such problems. DEVELOPMENT:Better understanding of both normal and abnormal...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-16 00:00:00
abstract:INTRODUCTION:In Parkinson's disease there are patients with isolated and multiple cognitive impairment, and their cognitive performance ranges from normal to an advanced degree of dementia. Most patients present an executive deficit, either in isolation or combined with other cognitive disorders, which is considered to...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-02-08 00:00:00
abstract:INTRODUCTION:Myasthenia gravis is an autoimmune disease of the neuromuscular junction that presents clinically as fluctuating weakness of skeletal muscles, as of the ocular region (myasthenia ocular). AIM:To demonstrate that the sensitivity and specificity of the ice pack test are high, in the differential diagnosis o...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Perinatal mortality has dropped markedly in recent years. However, there is still a considerable prevalence of neurological sequelas. Symptoms may present during the first months of life or later. Thus it is necessary to follow-up children with a clinical history of risk of neurological disorders. DEVELOP...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract::There are several syndromes in which neurological and cutaneous alterations of vascular origin, among other symptoms, occur. The key point of this fact is that these cutaneous signs permit early diagnosis, thus helping in further recognition of more complex syndromes and preventing unnecessary, harmful and costly diag...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract:INTRODUCTION:Despite progress in understanding its pathogenesis, there has not yet been found any independent predictive marker of aggressive behavior of pituitary adenomas, to facilitate the treatment and monitoring of patients. AIM:To analyze the expression of folliculo-stellate cells by immunostaining with S-100 pr...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Deep brain stimulation (DBS) is a surgical technique based on the placement of a programmable electrode into certain areas of central nervous system. DBS is nowadays a well established treatment for patients with Parkinson's disease (PD) and motor complications. However, there are controver...
journal_title:Revista de neurologia
pub_type: 共识发展会议,杂志文章,实务指引
doi:
更新日期:2009-09-16 00:00:00
abstract:INTRODUCTION:Hazardous alcohol consumption (HAC) is a pattern of alcohol use that may result in harm for the user and/or for those around them. Prior research has suggested that HAC and alcohol dependence share some neurophysiological features but differ in others. AIM:To determine whether HAC and alcohol dependence p...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2019-02-16 00:00:00
abstract::We have carried out an overall analysis of the diagnostic approach to generalized epileptic crises in children. It is emphasized that the clinical history is an essential factor in reaching the correct diagnosis. This is inevitably followed by a general and then a specifically neurological physical examination. Four p...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Cognitive deficits following lesions in parieto occipital areas tend to cause, among others, visuospatial and visuoperceptive alterations. The aim of this article is to examine the influence of others possible deficit over its rehabilitation. DEVELOPMENT:We discuss several patients who prese...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract:INTRODUCTION:The advantages of care in stroke units (UI) are known, as are those of being in neurology wards as compared with the general medical wards, although to date there are no studies which make a comparative evaluation of the stroke team (EI) as compared with the UI with regard to benefits in care obtained by t...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-01-16 00:00:00
abstract:INTRODUCTION:Decompression sickness (DS) is caused when bubbles of an inert gas usually nitrogen, since oxygen is metabolised in the tissues are released into the bloodstream and tissues during fast ascents once the atmospheric pressure is lowered near the surface. Neurological complications are its most serious form o...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Transient ischemic attacks (TIA) often precede a stroke. AIMS:The purpose of this study is to examine the modifiable cardiovascular risk factors for non-cardioembolic TIA. PATIENTS AND METHODS:A population based case control study was conducted in a district within the city of Barcelona. The cases were 1...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::Autism spectrum disorder (autism) is a highly prevalent and heterogeneous family of neurodevelopmental disorders of genetic origins with potentially devastating implications for child, family, health and educational systems. Despite advances in paper-and-pencil screening and in standardization of diagnostic procedures...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-02-25 00:00:00
abstract:AIM:Different patients exhibit wide variability in the way they respond to medications. Individual differences in drug response can result from environmental factors, as well as genetic determinants. In particular, inherited differences in the metabolism and disposition of drugs can have a great influence on the effica...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:Mental retardation (MR) is a clinical condition that may be due to a large variety of causes, the most important of which are those of a genetic origin, owing to the repercussions they can have on the family. There are more than one thousand types of MR with a genetic origin, and they are not usually found...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-07 00:00:00