Abstract:
:A comparative study was carried out to examine urinary excretion of D glucaric acid (DGA), g glutamyltransferase (GGT) activity and the concentration of serum bilirubin as enzymatic induction markers in 89 adult patients (56 men and 33 women) who were receiving chronic treatment with phenobarbital, phenytoin, carbamazepine and valproate. As in most cases, these drugs were administered as a polytherapy; drugs doses were expressed in units/day, in accordance with a previously described system of scoring, which would reflect the induction capacity of the combination of drugs administered. We found a high prevalence of results that were above the upper reference limit for urinary DGA (93.2%) and serum GGT (80.6%). Bilirubin and its conjugate and non conjugate fractions were found to offer values that to a large extent matched those of the control group. The levels of the different biochemical variables presented significant correlations with the daily doses of the drugs administered, above all in the case of DGA (r= 0.773, p< 0.001). When we split the data according to sex, the correlations improved in men but were significantly worse in women. This fact could be due to a greater inter individual variability in the response to inducers of the phenobarbital type in female patients. Urinary DGA seems to be a better enzymatic induction marker than GGT and bilirubin and its serum fractions, the value of which appeared to be very limited in these cases. Separating GGT into its isoforms provided no further information of practical interest as regards the enzymatic activity as a whole.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Tutor-Crespo MJ,Hermida-Ameijeiras J,Tutor-Valcarce JCsubject
Has Abstractpub_date
2002-10-16 00:00:00pages
711-6issue
8eissn
0210-0010issn
1576-6578pii
rn2002250journal_volume
35pub_type
杂志文章abstract:INTRODUCTION:In neuropathic pain, as occurs in epilepsy, researchers are striving to find a drug capable of inhibiting the pain-generating ectopic discharges that are produced as a result of neuronal hyperexcitability. This is mediated by ionic exchanges across the channels of the synaptic membrane. This is why the dru...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:Since the 1980s, in relation to the spread of AIDS, there has been an enormous increase in cryptococcosis, a mycotic disorder which usually affects the central nervous system (CNS). This disease is caused by Cryptococcus neoformans, a microorganism acquired by inhalation of bird excrement. This germ produc...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-05-16 00:00:00
abstract:TITLE:Aneurisma traumatico de la arteria meningea media en el contexto de un hematoma epidural. : ...
journal_title:Revista de neurologia
pub_type:
doi:10.33588/rn.6904.2019145
更新日期:2019-08-16 00:00:00
abstract:INTRODUCTION:The epilepsies of childhood are much more variable in expression and outcome than those of adults: the clinical and EEG features of epilepsy can change considerably with age. DEVELOPMENT:The neonatal epileptic encephalopathy, West and Lennox syndromes are present at different age, and each one shows a ste...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:White matter lesions are more prevalent in migraine patients than in the general population, especially those with a high frequency of attacks. A patent foramen ovale has been described as a possible link between migraine and white matter lesions. AIM:To determine the existence of a possible relationship ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:10.33588/rn.7010.2019435
更新日期:2020-05-16 00:00:00
abstract:OBJECTIVE:To standardize and to determine the structural validity of a conduct disorder self report questionnaire in adolescents. PATIENTS AND METHODS:One hundred ninety, 12 to 16 year old male participants from the different socioeconomic status were randomized selected from educational institutions of Medellin City,...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-06-16 00:00:00
abstract:INTRODUCTION:Over the last twenty years much work has been done to study the P300 in alcoholism. A systematically reduced amplitude, both in patients and in populations at risk (children of alcoholics) was found. Besides, studies on twins indicate that the waves of the evoked potentials are under genetic control. Furth...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-04-16 00:00:00
abstract:INTRODUCTION:Patients submitted to surgery to treat a brain aneurysm, who have suffered a subarachnoid haemorrhage, sometimes present cognitive disorders that can affect their social, familial, academic or occupational relationships. Memory disorders are frequent, although other cognitive functions may also be affected...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract:INTRODUCTION:The development of scientific advances, constantly opening new frontiers of knowledge, leads to increasing complexity and specialization. DEVELOPMENT:The conflict between the never ending medical specialization and the opposite tendency, which is based mostly on economic grounds, prevents the acquisition ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:An appropriate localization of ictal onset zone in refractory temporal lobe epilepsy favors an adequate outcome associated with surgical treatment. When video-electroencephalogram (video-EEG) and magnetic resonance imaging do not provide accurate data to locate ictal onset zone, the use of subdural or deep...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The aim of the study was the short term test-retest-reliability of electrophyisiological correlates of simple processes of the motor control, i.e. the execution (go) and the inhibition (no go) of a prepared motor response, evoked during the Continuous Performance Test (CPT). Our interest was centered in the ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The object of this study to analyse and compare the efficacy of the classic language tasks (repetition, phonological fluency and lexical decision), for the purpose of identifying the dominant hemisphere for language by means of functional magnetic resonance. SUBJECTS AND METHODS:The three tasks were performa...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-07-16 00:00:00
abstract:INTRODUCTION:Genetic etiology in suggested in intracranial aneurysms. Such hypothesis is supported on familial aggregation, ocurrence in identical twins or associated to genetic diseases like adult polycystic renal disease. OBJECTIVE:To identify biological features in familial aneurysms different to sporadic ones. PA...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
abstract:INTRODUCTION:Throughout history a number of speculations have been put forward concerning the functional role of the pineal gland, perhaps some of the most important being the neurophysiological proposals by Descartes. DEVELOPMENT:The psychophysiological role conferred on the pineal gland by Descartes in the 17th cent...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2010-01-16 00:00:00
abstract:OBJECTIVES:To obtain better understanding of the neurophysiology of sleep and of depression, together with any relationship there might be between them. DEVELOPMENT:We review the mechanisms of action of the neurotransmitters involved in the sleep-waking cycle, and also the antidepressive drugs, concentrating on those ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-16 00:00:00
abstract:INTRODUCTION:We describe a series of 10 children with intracranial hypertension complicating fulminant hepatic failure submitted to intracranial pressure (ICP) monitoring for intensive care and transplantation management. PATIENTS AND METHODS:Information from pediatrics patients acute liver failure admitted to our hos...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:The occupational environment generates a large amount of illness which involves several specialities, including neurology. However, there is little awareness--or little training--in this field as in most medical specialities, since in the basic tool of a doctor's work, the clinical history, importance is s...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract:TITLE:Meningoencefalitis tuberculosa con quistes aracnoideos medulares y siringomielia aguda. ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION:Several studies have found that individuals with multiple sclerosis (MS) experience relatively high rates of anxiety and depression; however, there are few reports about social anxiety in individuals with MS. AIM:To analyze the prevalence of social anxiety disorder and other psychiatric comorbidities in M...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:10.33588/rn.7002.2019213
更新日期:2020-01-16 00:00:00
abstract:INTRODUCTION:The treatment of cervical spondylosis may be medical, surgical or both. Surgical treatment is indicated mainly in patients with untreatable pain, progressive neurological deficit and proven compression of the nerve roots and spinal cord. Corporectomy with a graft and fusion is one of the most widely used t...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:The epidemiological importance of Acute Cerebrovascular Disorders (ECVA) has led to a need for specific units to care for these patients. We review the effect of these units on Neurology Departments. Development. In the 1970s Stroke Intensive Care Units were created. In the 1980s these units were replaced by ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::The amygdala is related with the recognition of the emotional meaning of stimuli, long-term memory, the orientation of social stimuli and the perception of gaze orientation. It plays a fundamental role in the recognition of faces, especially those expressing fear, and makes it possible to comprehend different emotiona...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-24 00:00:00
abstract:OBJECTIVE:To show the disorders of the brain cortical development and the possible origin in base to a large series studied in a Pediatric Neurology service. PATIENTS AND METHODS:A series of 144 children with ages ranging between newborn and 12 years was studied from the clinic, image (MR, 3DMR) and evolutive point of...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-16 00:00:00
abstract:TITLE:Signo del tridente en la neurosarcoidosis medular. : ...
journal_title:Revista de neurologia
pub_type:
doi:10.33588/rn.7005.2019180
更新日期:2020-03-01 00:00:00
abstract:TITLE:Parálisis súbita de la supraversión de la mirada en una niña de 9 años. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.7110.2020275
更新日期:2020-11-16 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:The objective of the study was to analyze the EEG tracings during the seizures of two monozygotic twins, shown on molecular analysis, diagnosed as having infantile epilepsy with absences. The recordings are particularly interesting since the genotypes of the patients are identical. This allow...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-12-16 00:00:00
abstract:INTRODUCTION:Lesions of the pyramidal system are characterized by their effects on qualitative aspects of movement. One of the features of pyramidal defects is the presence of associated movements or synkinesis. CLINICAL CASE:We present a case with residual associated electromyographic (EMG) response in a patient who ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Neuromodulation for treating pain goes back to the times of the ancient Egyptians, who applied natural electric currents to modulate the painful sensation. Since then, this concept has been developed in parallel with the scientific and technological development, and various forms of neuromodulation with different indi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-12-01 00:00:00
abstract:TITLE:Uso compasivo de cannabidiol en espray para el tratamiento de paraparesia espastica en un paciente con adrenomieloneuropatia. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Between 5 and 48% of the patients with Behçet s disease have neurological abnormalities. In children, meningoencephalitis as an initial manifestation of the disease is not frequent. CASE REPORT:We present a four years old girl with a Behçet s disease. When she was six months of age, during an hospitalizat...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00