Abstract：
INTRODUCTION:Over the last twenty years much work has been done to study the P300 in alcoholism. A systematically reduced amplitude, both in patients and in populations at risk (children of alcoholics) was found. Besides, studies on twins indicate that the waves of the evoked potentials are under genetic control. Furthermore, advances in molecular genetic techniques have clarified the part played by the allele A1 of the gene which codifies the D2 dopamine receptor in alcoholism. Only in recent years have studies been published relating them and in these they are considered to be risk markers for alcoholism. However, contradictory results have been obtained. DEVELOPMENT:The objective of this study is to review part of the literature and find evidence for and against the characteristics observed in the P300 and the possible part played by the DRD2 gene in the aetiology of alcoholism and the relationship between them. At the same time we consider the most relevant theoretical aspects of the role played by dopamine in the central nervous system, since some studies have shown that it is involved in the generation of P300 and reinforcement due to alcohol consumptions. Finally, we discuss the advantages and disadvantages that should be taken into account when considering the low amplitude of P300 and the presence of the A1 allele as diagnostic markers to identify populations at risk and thus avoid appearance of the disorder.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Nácher Vsubject
Has Abstractpub_date
2000-04-16 00:00:00pages
756-63issue
8eissn
0210-0010issn
1576-6578journal_volume
30pub_type
杂志文章,评审abstract：AIMS:The aim of this study was to carry out a review of the state of the art in the endovascular treatment of carotid disease, taking into account the findings currently available, its indications, the technical aspects linked to the intervention as well as those related to the occupational training of the specialists ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-16 00:00:00
abstract：INTRODUCTION:In the last decades psychological studies have demonstrated the effectiveness of the cognitive-behavioural therapy for most anxiety and depressive disorders. Recently, a different and complementary approach in terms of validation of cognitive-behavioural therapy has emerged: testing the efficacy of these t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
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abstract：INTRODUCTION:From time to time the debate over whether early-onset epileptic seizures are harmless or have harmful effects on the developing brain reappears. DEVELOPMENT:We evaluated the results of clinical studies reporting the long-term cognitive development of children who suffer from early-onset epilepsies, that i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-05-21 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-16 00:00:00
abstract：INTRODUCTION:The capability of the electroencephalography (EEG) of recording the bioelectrical activity of the brain has made of it a fundamental tool for the evaluation of the patient's neurological condition. In recent years, moreover, it has also begun to be used in obtaining information for other kind of variables,...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.6809.2018179
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journal_title：Revista de neurologia
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doi：
更新日期：2004-04-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2018-09-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Revista de neurologia
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journal_title：Revista de neurologia
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更新日期：2006-04-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-05-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-09-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
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doi：
更新日期：2011-12-01 00:00:00
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更新日期：2004-05-01 00:00:00
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doi：
更新日期：2002-08-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2003-10-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：2005-04-01 00:00:00
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journal_title：Revista de neurologia
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更新日期：1997-06-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
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journal_title：Revista de neurologia
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doi：
更新日期：1997-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-04-16 00:00:00
