Abstract：
INTRODUCTION:At present, cholinesterase inhibitors constitute the basis for therapy of Alzheimer's disease (AD); these drugs were rationally introduced given the loss of central cholinergic neurotransmission, even though there are many other systems affected in AD, including glutamatergic pathway. DEVELOPMENT:In addition to the loss of central cholinergic neurotransmission, biochemical evidence suggests glutamatergic dysfunction in AD and thus, therapeutic strategies directed at the glutamatergic system may be useful. These drugs include milacemide, cicloserine and ampakines (positive modulation) and memantine (negative modulation). Lithium seems to be a promising agent in AD, although the mechanism of action is poorly understood. Finally anti-inflammatory agents may be another therapeutic approach to AD. CONCLUSION:In addition to drugs acting on the cholinergic system, a large number of drugs with different mechanism could be used for the treatment and prevention of AD.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
García-Ruiz Espiga PJ,Echeverría A,García-Torres A,Contreras Asubject
Has Abstractpub_date
2006-04-16 00:00:00pages
478-81issue
8eissn
0210-0010issn
1576-6578pii
rn2005218journal_volume
42pub_type
杂志文章,评审abstract：INTRODUCTION:Surgical treatment for thoracolumbar union instability represents a challenge, due to the difficult access to this area of the spine, and to the extreme variability of morphological and biomechanical lesions observed. AIM:To describe the indications and clinical and neuroradiological results obtained with...
journal_title：Revista de neurologia
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更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:It is a well-known fact that a relatively high proportion of patients with essential tremor are resistant to a number of pharmaceuticals currently used to treat the condition. AIM:To assess the effectiveness and safety of levetiracetam (LEV) in patients who displayed little or no response or intolerable s...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
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更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To present a new formulation of human death based on neurological considerations. DEVELOPMENT:One of the reasons there is still controversy over a new formulation of human death which is acceptable to society, is that many authors do not suitably integrate three fundamental aspects which should be included i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:Brain creatine deficiencies are a group of inborn errors of metabolism recently recognized which are caused by arginine: glycine amidinotransferase (AGAT) deficiency, guanidinoacetate metiltransferase (GAMT) deficiency and defects in creatine transporter (CRTR). Although all of them are characterized by a ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-03-16 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:Neuropsychological performance in obsessive compulsive disorder (OCD) and its association with disfunctions in neuroanatomic structures and clinical symptoms of disorder has been reviewed. DEVELOPMENT:OCD symptoms and different aspects between children and adult psychopatology are presented....
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-16 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown. Nevertheless, one of the most acceptable possibilities facing the origin of the tumor is the remaining rests of cere...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-16 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:We present a diagnostic decision tree for the correct use of neuropsychological evaluation techniques in head injury. Our aim is to avoid extensive, intensive use of unnecessary tests and measurements or lapses into diagnostic error which often accompany cognitive dysfunction when 'superficia...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-16 00:00:00
abstract：INTRODUCTION:Cerebral vascular malformations (CVM) are a heterogeneous group of lesions. One way of classifying them is according to histological criteria, clinical features, imaging findings, electroencephalography and distinctive pathology. OBJECTIVES:To report the results obtained in 16 patients clinically diagnose...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:The aim of the study is a reflection on the current standing of giftedness research and the effectiveness of gifted education in order to facilitate its optimal developmental trajectory from potential to eminence. The necessity of rethinking high intellectual ability as a developmental process is exposed from a new pa...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-02-25 00:00:00
abstract：INTRODUCTION:Lymphomas of the central nervous system include primary and secondary lymphomas of Hodgkin and non-Hodgkin types. For a long time central nervous system involvement during the course of systemic non-Hodgkin lymphoma has been considered unusual, to occur late on in the disease process and usually to be loca...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：INTRODUCTION:Primary bone lymphomas account for 3-7% of all malignant bone tumours and less than 2% of lymphomas in adults. Having the cranial vault as their primary location is very infrequent. CASE REPORT:A 59-year-old female who presented a painful tumour on the cranial vault which, following radical surgical remov...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-12-16 00:00:00
abstract：INTRODUCTION:Both the moment and the way chosen to break the news that a child aged 0-6 years is suffering, or may suffer, from a developmental disorder or disability have an effect on the parents and on the familial system that goes beyond the actual fact of knowing about the circumstance in itself. It is a very signi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-02-29 00:00:00
abstract：INTRODUCTION:Oxidative stress increases brain lipid peroxidation, memory and motor deficits and progressive neurodegeneration. Tibolone, a treatment for menopausal symptoms, decreases lipid peroxidation levels and improves memory and learning. AIM:To study the effect of chronic administration of tibolone on lipid pero...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-05-16 00:00:00
abstract：INTRODUCTION:For conscious behaviours to continue, attention and working memory must be brought into play in order to match the data from the current reality with those in the long-term memory and to the sequential plans for adaptive action. PATIENTS AND METHODS:We present the preliminary findings of our study of 50 p...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-15 00:00:00
abstract：OBJECTIVES:To test the clinical nature and diversity of specific language impairment (SLI) in Spanish individuals, in the framework of the neuropsycholinguistic model of Chevrie-Muller and the classification of Rapin and Allen. PATIENTS AND METHODS:Forty two language impaired children with normal intelligence and audi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-01 00:00:00
abstract：INTRODUCTION:Akinetic mutism is considered as an alteration of the motivational state of the person, which the patient is unable to initiate verbal or motor responses voluntary, even with preserved sensorimotor and surveillance functions. CASE REPORT:A 43 year-old male involved in a cerebellum arteriovenous fistula co...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-01-16 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Frontal lobe, more specifically prefrontal cortex, is one of the brain regions that undergoes more protracted ongoing development. The wider the developmental window of one brain structure, the more vulnerable the functions related to it. Hence, executive functions, which are mediated by pr...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-07-16 00:00:00
abstract：OBJECTIVE:The author reviews the value of the electrophysiological techniques: electromyography (EMG), electroneurography or motor and sensitive nerve conduction velocity (MCV, SCV), brainstem auditory potentials (BAER), visual evoked potentials (VEP) and electroretinography (ERG), somatosensory evoked potentials (SEP)...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Reported observations of acquired aphasia in children contain all the symptoms and syndromes that have been described in adult aphasiology. Recovery of colloquial language is good even if anomia and verbal memory deficits persist as the most frequent defects. At long term outcome there are ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:The cognitive effects of the most commonly used antiepileptic drugs (AEDs) are reviewed, discussing both the absolute effects (the effects compared to no treatment) and the relative effects (the comparison of one AED with an other). The cognitive profile per AED is given, based on a literature database, consisting of ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
abstract：INTRODUCTION:Myasthenia gravis is an autoimmune disease of the neuromuscular junction that presents clinically as fluctuating weakness of skeletal muscles, as of the ocular region (myasthenia ocular). AIM:To demonstrate that the sensitivity and specificity of the ice pack test are high, in the differential diagnosis o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
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journal_title：Revista de neurologia
pub_type：
doi：
更新日期：1998-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-08-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：INTRODUCTION:Advances in neuroimaging in the last decade have allowed a number of new findings about attention deficit hyperactivity disorder (ADHD) to be obtained. Quickly developing technology, together with the progress being made in genetics and neurochemical research, suggests a dysfunction of the fronto striatal ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-03 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-02-16 00:00:00
abstract：INTRODUCTION:The new antiepileptic drugs should also be evaluated outside clinical trials. OBJECTIVE:To study the efficacy of treatment with lamotrigine in everyday neuropaediatric clinical practice. PATIENTS AND METHODS:We made a longitudinal study of all patients treated with lamotrigine in a hospital outpatients d...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-07-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2010-04-16 00:00:00
abstract：INTRODUCTION:Cerebrovascular accidents (CVA) are the third most common cause of death and are the main cause of permanent disability in the western world, where they also rank first as regards the loss of years of disability-adapted independent life. Ischaemic CVAs tend to present irreversible sequelae, which reduces t...
journal_title：Revista de neurologia
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-11-01 00:00:00
