Abstract：
AIM:Different patients exhibit wide variability in the way they respond to medications. Individual differences in drug response can result from environmental factors, as well as genetic determinants. In particular, inherited differences in the metabolism and disposition of drugs can have a great influence on the efficacy and toxicity of medications, so herein we focus on the pharmacogenetics of drug metabolism. DEVELOPMENT:Clinical observations of inherited differences in drug effects were first documented in the 1950s, giving rise to the field of pharmacogenetics. These observations were then followed by population studies of drug disposition phenotype, then biochemical, and eventually molecular elucidation of the genetic defect associated with the inherited trait. Genetic polymorphisms have been described for many phase I and phase II drug-metabolizing enzymes including several cytochromes P450, N-acetyltransferases, and thiopurine S-methyltransferase. Rapid advances in human genomics gave birth to pharmacogenomics, an emerging discipline that uses genome-wide approaches to study the entire spectrum of genes involved in drug response. High-through-put genomic technologies will serve as the foundation of personalized therapies. CONCLUSIONS:Knowledge of an individual's genetic variability in drug response may be clinically and economically important and could provide the basis for a rational approach to drug prescription in neuropsychiatric disorders.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
López-López M,Guerrero-Camacho JL,Familiar-López IM,Jung-Cook H,Corona-Vázquez T,Alonso-Vilatela MEsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
1063-71issue
11eissn
0210-0010issn
1576-6578pii
rn2004276journal_volume
39pub_type
杂志文章,评审abstract：INTRODUCTION:Episodes of recurrent bacterial meningitis can occur in patients due to either congenital or acquired disorders. Congenital deformity of the bony labyrinth can be linked to a fistulous tract communicating it with the intracranial subarachnoid space. Mondini deformity is a frequent malformation in congenita...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-11-16 00:00:00
abstract：INTRODUCTION:The description of Upper Airway Resistance Syndrome (UARS) let us to recognize the importance of the pair 'respiratory effort-arousal' on sleep-disordered breathing pathophysiology. DEVELOPMENT:First part of this paper reviews knowledge about respiratory arousal pathophysiology. Arousal response is normal...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-16 00:00:00
abstract：TITLE:XXXI Reunion da Sociedade Galega de Neuroloxia. Comunicaciones. : ...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-07-16 00:00:00
abstract：INTRODUCTION:The subarachnoid haemorrhage non traumatic assumes between the 6-8% of all acute cerebrovascular, besides is more frequent in young persons. The mortility and mortality is high and the predictive factors of the worse prognostic in unknown. MATERIAL AND METHODS:In the present work, we realized a study of t...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Reported observations of acquired aphasia in children contain all the symptoms and syndromes that have been described in adult aphasiology. Recovery of colloquial language is good even if anomia and verbal memory deficits persist as the most frequent defects. At long term outcome there are ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Decompression sickness (DS) is caused when bubbles of an inert gas usually nitrogen, since oxygen is metabolised in the tissues are released into the bloodstream and tissues during fast ascents once the atmospheric pressure is lowered near the surface. Neurological complications are its most serious form o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：INTRODUCTION:Skull base metastases (SBM) are an infrequent and late type of cancer progression that are associated to poor prognosis. Its clinical manifestations may be grouped in five clinical syndromes and radiotherapy is its more frequent treatment. Because of the improvement in imaging tests and the close follow up...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-03-01 00:00:00
abstract：:Three phases are recognized in the natural history of infection by the human immunodeficiency virus (HIV): (a)an early or acute phase lasting several weeks, (b) an intermittent or chronic phase, with active low-grade viral replication, lasting several years and (c) the final stage or crisis, which corresponds to the c...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1996-12-01 00:00:00
abstract：INTRODUCTION:Autism spectrum disorders (ASD) are neurodevelopmental disorders that affect social communication and present stereotypic behaviours. Comorbidity associated to conduct disorders is frequent, starts in infancy and, in general, continues into adulthood. It is sometimes associated with aggressiveness, negativ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Epilepsy and the epileptic syndromes are common neurological diseases and represent an important public health problem that has given rise to marked social and healthcare concerns. AIM:To analyse the changes in the consumption of antiepileptic drugs in the Basque Country Autonomous Community over a 13 yea...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-04-16 00:00:00
abstract：:The amygdala is related with the recognition of the emotional meaning of stimuli, long-term memory, the orientation of social stimuli and the perception of gaze orientation. It plays a fundamental role in the recognition of faces, especially those expressing fear, and makes it possible to comprehend different emotiona...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-24 00:00:00
abstract：AIM:To identify the clinical and psychosocial factors of a Colombian cohort of patients with juvenile myoclonic epilepsy and its relation to crisis control. PATIENTS AND METHODS:Retrospective cohort study of patients over 14 years of age with a diagnosis of juvenile myoclonic epilepsy, with 12 months of follow-up in a...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.6911.2019305
更新日期：2019-12-01 00:00:00
abstract：:There are several syndromes in which neurological and cutaneous alterations of vascular origin, among other symptoms, occur. The key point of this fact is that these cutaneous signs permit early diagnosis, thus helping in further recognition of more complex syndromes and preventing unnecessary, harmful and costly diag...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：:Optical coherence tomography (OCT) is a non-invasive imaging technique that allows the different layers of the retina to be visualised in vivo. One of them is the so-called retinal nervous fibre layer (RNFL), which is made up of amyelinic axons from the ganglionic cells, and therefore part of the central nervous syste...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-05-01 00:00:00
abstract：:By means of the modified trichromic method of Gomori, introduced by Engel and Cunningham in 1963 [1], it has been possible to demonstrate the presence of ragged-red fibers (RRF) in the mitochondrial myopathies. At present, to study these disorders in muscle biopsies, one may also use morphological, ultrastructural, hi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-04-01 00:00:00
abstract：AIM:To identify the clinical features that predict a favourable response to onabotulinumtoxinA (OnabotA) treatment in patients with refractory migraine. PATIENTS AND METHODS:Retrospective analysis of patients with refractory migraine who underwent at least two pericranial injections of OnabotA between 2008 and 2012. P...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-03-16 00:00:00
abstract：AIMS:The purpose of this study was to establish certain epidemiological characteristics of cerebral aneurysm surgery at the Hospital Regional Docente Vicente Corral Moscoso (HVCM), in the city of Cuenca. PATIENTS AND METHODS:We examined the medical records of the patients who were treated at the HVCM, in Cuenca, over ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：INTRODUCTION:Non-verbal learning disorder (NVLD) is the name given to a complex group of difficulties with a well-defined biological substrate. Their clinical manifestations affect the motor area, visuospatial organisation and the social competencies. AIM:To analyse the semiology that differentially identifies NVLD by...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-27 00:00:00
abstract：:The new communication techniques and, particularly, Internet, are changing our way of collaborating, relating to each other and searching for information, paving the way for telemedicine. Such initiatives are described in the Revista de Neurologia, as well as the methodology followed to prepare the first Electronic Fo...
journal_title：Revista de neurologia
pub_type： 社论
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:Increased survival of patients with stroke, and reduction in the time spent in hospital, has led to more domiciliary care and extra problems of adjustment for the patient chronically disabled by the stroke and for his carer. MATERIAL AND METHODS:Ninety patient-carer units from the Stroke Unit of the Hospi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-16 00:00:00
abstract：INTRODUCTION:It is known as segmental neurofibromatosis type 1 (NF1) a type of NF1 characterized by the features circumscribed to one or more body cutaneous and/or subcutaneous segments. This entity is recognized from recently and it is related with somatic mosaicism. PATIENTS AND METHODS:43 patients (29 females and 1...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-10-16 00:00:00
abstract：INTRODUCTION:Arachnoid cysts are cavities with a content similar to cerebrospinal fluid, frequently communicating with the subarachnoid space. They make up 1% of the intracranial space occupying lesions, and although typically seen in children (13%), they may be undiagnosed until the patient has become adult. PATIENTS...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-08-16 00:00:00
abstract：OBJECTIVE:To show the neurological disorders associated with ocular changes mainly affecting retina and which can be seen during the first year of age. DEVELOPMENT:It is used the personal experience and the reported papers of the literature related with the subject to make a short review of the main neurological, bioc...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:INTRODUCTION. A large number of neurological diseases course with impairment of higher cognitive functions, their evaluation being important for diagnostic, prognostic and therapeutic purposes. The main purpose of neuropsychological assessment is to identify behavioral, emotional and cognitive consequences of brain dy...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-12-16 00:00:00
abstract：TITLE:Telemedicina en pediatría del neurodesarrollo durante la pandemia de COVID-19: experiencia en un hospital terciario. ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.7112.2020554
更新日期：2020-12-16 00:00:00
abstract：INTRODUCTION:The Aragon Stroke Care Plan (PAIA) was created in 2008 within the framework of the Spanish National Health System. Monitoring hospital care of strokes by means of periodic audits was defined as one of its lines of work. AIM:To determine the quality of the hospital care process for stroke patients in Arago...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2016-07-16 00:00:00
abstract：INTRODUCTION:A great deal of research has addressed problems in the correct acquisition of language, but with few overall conclusions. The reasons for this lie in the individual variability, the existence of different measures for assessing language and the fact that a complex network of genetic and environmental facto...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The damage caused to the central nervous system by lightning can be immediate or delayed. Cerebrovascular accidents are usually an infrequent complication of lightning strikes. CASE REPORT:We report the case of a patient who was hit by lightning and then developed an acute bilateral intraparenchymatous ha...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-16 00:00:00
abstract：INTRODUCTION:Performing amniocentesis between the fourth and sixth months of gestation is a widespread practice. However, it can entail serious consequences, apart from the loss of the foetus, such as injuries to the developing central nervous system. CASE REPORTS:Over the past few years we have dealt with four patien...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Magnetic resonance is the most sensitive para-clinical method available for the diagnosis of multiple sclerosis since it shows changes in 95% of the patients with clinically definite multiple sclerosis. However, little correlation has been found, in different studies, between the parameters of magnetic resonance and t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-16 00:00:00
