Abstract：
INTRODUCTION:FOXP2 is the first gene linked to a hereditary variant of specific language impairment and seems to code for a transcriptional repressor that intervenes in the regulation of the development and the functioning of certain thalamic-cortical-striatal circuits. DEVELOPMENT:In the last three years, significant progress has been made in the determination of the structural and functional properties of the gene. These advances essentially have to do with the precise analysis of the most important structural motifs of the protein that it codes for and the main parameters that determine its interaction with DNA. They also concern the determination of the functional and behavioural properties in vivo of the main isoforms of the FOXP2 protein, the exact determination of the pattern of expression of new orthologues of the gene, and the identification of the different target genes for factor FOXP2. CONCLUSIONS:This new evidence suggests that protein FOXP2 protein has a high degree of versatility in vivo when it comes to binding to DNA; that its different isoforms are biologically functional; and that the FOXP2 gene is functional during embryonic development and during the adult phase. It also suggests that it is involved in the development and/or functioning of the thalamic-cortical-striatal circuits associated to motor planning, sequential behaviour and procedural learning (a significant saving in developmental terms of the regulatory mechanism in which the gene is involved), as well as the accuracy of the models of linguistic processing that consider language to be, to a large extent, the result of an interaction between certain cortical and subcortical structures.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Benítez-Burraco Asubject
Has Abstractpub_date
2008-03-16 00:00:00pages
351-9issue
6eissn
0210-0010issn
1576-6578pii
rn2008124journal_volume
46pub_type
杂志文章,评审abstract：AIM:To present seven tumors of the cerebral hemispheres in 6 children with neurofibromatosis type 1 (NF1). PATIENTS AND METHODS:Six patients (three males and three females) of 600 cases of a series with NF1 showed features of cerebral hemispheres tumor (seizures, headache and hemiparesis). They were studied neurologic...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2010-04-16 00:00:00
abstract：INTRODUCTION:Various neuropsychological studies have been conducted to determine the cognitive functioning of patients with Huntington s disease and their results have shown that the pattern of cognitive decline is thought to be typical of a frontal subcortical dementia. OBJECTIVES:To determine if significant differen...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:To standardize and to determine the structural validity of a conduct disorder self report questionnaire in adolescents. PATIENTS AND METHODS:One hundred ninety, 12 to 16 year old male participants from the different socioeconomic status were randomized selected from educational institutions of Medellin City,...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-06-16 00:00:00
abstract：INTRODUCTION:Reye s syndrome (RS) is a potentially fatal disease described in 1963 by Reye, Morgan and Baral as an acute encephalopathy associated with a lipid degeneration of the liver. It affects children of all ages, with a peak incidence between 5 and 15 years old, but on rare occasions it can also affect adults. I...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-09-16 00:00:00
abstract：INTRODUCTION:Autism spectrum disorders (ASD) are neurodevelopmental disorders that affect social communication and present stereotypic behaviours. Comorbidity associated to conduct disorders is frequent, starts in infancy and, in general, continues into adulthood. It is sometimes associated with aggressiveness, negativ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:To analyze the available scientific evidence regarding treatment with thrombolytic agents in patients with cerebrovascular disease and present this in the context of daily practice. DEVELOPMENT:Publication of the NINDS study of treatment with t-PA for acute cerebral ischemia led to approval of this treatment...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-12-16 00:00:00
abstract：INTRODUCTION:In recent years, significant advances have been made in the physiology and the pharmacology of vestibular disorders. It is now possible to elaborate an approximation of the mechanisms of action of the drugs used in the symptomatic treatment of vertigo. DEVELOPMENT:These drugs usually have a number of diff...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-16 00:00:00
abstract：INTRODUCTION:Patients submitted to surgery to treat a brain aneurysm, who have suffered a subarachnoid haemorrhage, sometimes present cognitive disorders that can affect their social, familial, academic or occupational relationships. Memory disorders are frequent, although other cognitive functions may also be affected...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：INTRODUCTION:A large number of diseases present as bilateral striatal lesion syndrome (BSLS). Clinical manifestations, course and prognosis of these diseases are extremely variable. On the basis of their evolutive course, they can be separated into two major groups: acute, which include toxic, infectious or parainfecti...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-12-16 00:00:00
abstract：INTRODUCTION:In partial seizures, from a clinical point of view or even from electroencephalography characterization of post-ictal period can be difficult. The spectral and complex network analysis could lead to a more accurate definition of its limits, as well as to a great understanding of the seizures. PATIENTS AND...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2017-04-16 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Little data has been published in Spain on motor neurone disease or amyotrophic lateral sclerosis. This study reports data on incidence and mortality in Cantabria and incidence in Segovia. It discusses and compares them emphasizing certain characteristic features of the epidemiology of the d...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：1999-11-01 00:00:00
abstract：:What appears in this article is nothing more than a series of reflections on psychiatry and neurology based on my own experience as an educator, practitioner and scholar of both disciplines. It is not, therefore, a piece of research work in the usual sense of the word. Such has been my commitment to Revista de Neurolo...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-12-16 00:00:00
abstract：INTRODUCTION:Latin American medicine in the 16th century produced the first collections of herbs with native plants from the New World. Treatises on popular therapies appeared, which included gallenic remedies as well as incorporating autochthonous plants. We review the main neurological diseases and their treatments d...
journal_title：Revista de neurologia
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2009-08-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:The history of prion diseases is one of the most exciting chapters of the story of medicine in the twentieth century. It began in the nineteen twenties when Creutzfeldt (in one patient) and Jakob (in five patients) described a clinically polymorphic cerebral syndrome with a subacute or chro...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2000-07-16 00:00:00
abstract：INTRODUCTION:Since the 1980s, in relation to the spread of AIDS, there has been an enormous increase in cryptococcosis, a mycotic disorder which usually affects the central nervous system (CNS). This disease is caused by Cryptococcus neoformans, a microorganism acquired by inhalation of bird excrement. This germ produc...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-05-16 00:00:00
abstract：INTRODUCTION:The thoracic outlet syndromes are clinical conditions whose true incidence is low, although they are frequently diagnosed. They are caused by compression of the brachial plexus or vascular structures due to anatomical anomalies of the cervico-axillary region. DEVELOPMENT:Two main types are seen: the neuro...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the treatment modalities used in children (ages 1-18 years) with cerebral infarction. BACKGROUND:[corrected] Cerebrovascular disease in children is more common than once suspected but its treatment has not been rigorously studied. MATERIAL AND METHODS:We reviewed all cases of cerebral infarction...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：INTRODUCTION:Dreams are a universal human experience and studying them from the point of view of neuroscience, consciousness, emotions and cognition is quite a challenge for researchers. Thus, dreams have been addressed from a number of different perspectives ranging from philosophy to clinical medicine, as well as psy...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-16 00:00:00
abstract：INTRODUCTION:Performing amniocentesis between the fourth and sixth months of gestation is a widespread practice. However, it can entail serious consequences, apart from the loss of the foetus, such as injuries to the developing central nervous system. CASE REPORTS:Over the past few years we have dealt with four patien...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To determine clinical and pathological features with seizures associated brain tumors. PATIENTS AND METHODS:This was a retrospective study through of an Epilepsy Program Protocol where we studied fifty patients admitted at Hospital Universitário Cajuru of Curitiba, Brazil, in 1996-1997. RESULTS:We studied 3...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：INTRODUCTION:Alzheimer's disease is 1.5 to 3 times more frequent in women than in men. This fact can be biased as women as a group have more long life survival. Semantic memory and naming are more frequently and severely impaired in women. DEVELOPMENT:Both genetic and environmental factors can contribute when one dete...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-06-16 00:00:00
abstract：INTRODUCTION:Encephalitis due to NMDA receptors antibodies is a relatively common condition but it was under diagnosed until recently. It courses predictably and similarly in adults and children, although there are some differences, still less its association with tumours. CASE REPORT:A 3 years-old girl who was admitt...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-11-16 00:00:00
abstract：INTRODUCTION:Perforating artery disease is still the main cause of lacunar infarcts (LI), while the relationship between this type of ischemia and carotid stenosis (CS) is controversial. OBJECTIVE:To assess the association between CS and LI in patients with criteria of localized ischemia in the carotid territory separ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-07-16 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:Deep brain stimulation (DBS) is a surgical technique based on the placement of a programmable electrode into certain areas of central nervous system. DBS is nowadays a well established treatment for patients with Parkinson's disease (PD) and motor complications. However, there are controver...
journal_title：Revista de neurologia
pub_type： 共识发展会议,杂志文章,实务指引
doi：
更新日期：2009-09-16 00:00:00
abstract：AIMS:The study reviews language disorders in children. Taking their normal development as the starting point, the work puts forward a differential diagnosis based on the symptoms presented in the moment the patient visited the physician. It also suggests an approach for children with language disorders from the neuropa...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-06 00:00:00
abstract：INTRODUCTION:The risk of falls in older adults increases because of the decrease in strength, flexibility, balance and sensory changes affecting functionality and quality of life. For this reason, an integral system of evaluation of equilibrium is necessary, for preventive purposes or for early therapeutic intervention...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-11-16 00:00:00
abstract：:The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting held in Madrid in October 2013, resulting in this review, which is being p...
journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2014-10-16 00:00:00
abstract：INTRODUCTION:Depression is a state of mind often associated with Parkinson's disease, which is not correlated with the stage of the disease or the response to treatment with L-dopa. It has been suggested that patients with right-sided Parkinsonism have more depression than those with left-sided. OBJECTIVE:To assess wh...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-12-16 00:00:00
abstract：INTRODUCTION:This paper review current literature about neurocysticercosis with emphasis on recent advances on diagnosis and therapy. DEVELOPMENT:Cysticercosis is the most common parasitic disease of the nervous system. The disease occurs when humans become the intermediate host in the life cycle of Taenia solium by i...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：INTRODUCTION:There is currently a growing interest for conducting studies into the electrical and neurochemical activity of the pedunculopontine nucleus (PPN) due to the privileged position occupied by this structure in the flow of information to and from the cortex. This nucleus acts as a relay, not only for the motor...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-16 00:00:00
