Abstract:
INTRODUCTION:Various neuropsychological studies have been conducted to determine the cognitive functioning of patients with Huntington s disease and their results have shown that the pattern of cognitive decline is thought to be typical of a frontal subcortical dementia. OBJECTIVES:To determine if significant differences exist between the cognitive performances of a group diagnosed with Huntington s disease and a group of healthy, at risk relatives on a series of neuropsychological tests, and to examine the extent to which the Huntington group s cognitive performance profile corresponds to frontal subcortical damage as reported in other studies. PATIENTS AND METHODS:The sample was comprised of a group of 18 subjects with a clinical diagnosis of initial stage Huntington s disease and a group of 15 healthy relatives at risk for Huntington s disease. A battery of tests (the CERAD) and additional neuropsychological tests were administered to all subjects. RESULTS:Compared to the at risk group, the Huntington s disease group scored significantly lower on 85.41% of the tests. CONCLUSIONS:The neuropsychological tests utilized in this study were useful to discriminate between diagnosed and at risk groups. The Huntington s disease group s global neuropsychological profile was similar to that of a frontal subcortical dementia in which the predominant features include executive functioning deficits, memory problems, visuo constructive alterations, attention deficits, verbal fluency problems and naming deficits.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Arango-Lasprilla JC,Iglesias-Dorado J,Moreno S,Lopera Fsubject
Has Abstractpub_date
2003-07-01 00:00:00pages
7-13issue
1eissn
0210-0010issn
1576-6578pii
rn2002493journal_volume
37pub_type
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