Abstract：
INTRODUCTION:There is currently a growing interest for conducting studies into the electrical and neurochemical activity of the pedunculopontine nucleus (PPN) due to the privileged position occupied by this structure in the flow of information to and from the cortex. This nucleus acts as a relay, not only for the motor information that is processed in the basal ganglia but also for information of an emotional type, whose main centre is the nucleus accumbens. It is also strongly linked with the aspects that determine the mechanisms governing addiction to certain drugs. DEVELOPMENT:We conduct a detailed analysis of the main findings from studies of the role played by the PPN in the physiopathology of Parkinsonism, namely the study of metabolic activity, immunohistochemical studies with different tracers, electrophysiological studies that have confirmed the immunohistochemical observations, as well as deep electrical stimulation carried out in non human primates. Furthermore, we also examine the part played by this structure in the processing of emotional information associated with different learning tasks. CONCLUSIONS:Overall, the authors grant the PPN a privileged position in the physiopathology of the axial disorders related to Parkinson s disease; its most important afference, stemming from the subthalamic nucleus, appears to play a key role in the understanding of the part played by the PPN in Parkinsonism.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Blanco-Lezcano L,Pavón-Fuentes N,Serrano-Sánchez T,Blanco-Lezcano V,Coro-Grave de Peralta Y,Joseph-Bouza Ysubject
Has Abstractpub_date
2003-06-16 00:00:00pages
1181-5issue
12eissn
0210-0010issn
1576-6578pii
rn2003064journal_volume
36pub_type
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journal_title：Revista de neurologia
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pub_type： 杂志文章
doi：
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
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doi：
更新日期：2002-05-16 00:00:00
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pub_type： 杂志文章,评审
doi：
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pub_type： 杂志文章
doi：
更新日期：2003-05-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-12-16 00:00:00
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doi：
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
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