Abstract:
INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relapsing-remitting MS (RRMS) and primary progressive MS (PPMS). The clinical trials conducted for both the relapsing forms (OPERA I/II) and the progressive forms of the disease (ORATORIO) have demonstrated its efficacy. The aim of this review is to address the main aspects of the efficacy and safety of ocrelizumab in MS. DEVELOPMENT:Using PubMed, a literature review was conducted of studies published at the ECTRIMS 2017 Congress and of active studies in ClinicalTrials. In order to evaluate the efficacy and safety of ocrelizumab in MS, both randomised clinical trials and their extension and follow-up studies were reviewed, and information about its safety obtained from monitoring programmes of the Food and Drug Administration and European Medicines Agency was included. CONCLUSIONS:Ocrelizumab is the first drug that has been shown to be able to significantly slow disability progression at 12 and 24 weeks in patients with PPMS. It is also effective in controlling clinical and radiological activity in patients with RRMS forms, and it is approved and indicated for both phenotypes of the disease. To date, the safety profile of ocrelizumab matches that observed in clinical trials, without any unexpected alerts. TITLE:Ocrelizumab: eficacia y seguridad en la esclerosis multiple. :Introduccion. El ocrelizumab es un anticuerpo monoclonal humanizado contra el antigeno CD20 de las celulas B. Ha sido aprobado recientemente por las agencias sanitarias estadounidense (Food and Drug Administration) y europea (European Medicines Agency) para el tratamiento de la esclerosis multiple (EM), y supone el primer farmaco comercializado tanto para la EM remitente recurrente (EMRR) como para la EM primariamente progresiva (EMPP). Los ensayos clinicos, tanto para formas recurrentes (OPERA I/II) como para las formas progresivas de la enfermedad (ORATORIO), han demostrado su eficacia. El objetivo de esta revision es abordar los principales aspectos de eficacia y seguridad del ocrelizumab en la EM. Desarrollo. Se ha realizado una revision bibliografica a traves de PubMed de trabajos publicados en el congreso ECTRIMS 2017 y de estudios activos en ClinicalTrials. Con el fin de evaluar la eficacia y seguridad del ocrelizumab en la EM, se han revisado ensayos clinicos aleatorizados, asi como sus estudios de extension y de seguimiento, y se ha incluido informacion sobre seguridad de los programas de monitorizacion de la Food and Drug Administration y la European Medicines Agency. Conclusiones. El ocrelizumab es el primer farmaco que ha demostrado poder frenar de forma significativa la progresion de la discapacidad en 12 y 24 semanas en pacientes con EMPP. Es tambien eficaz en el control de la actividad clinica y radiologica en pacientes con formas de EMRR, y su aprobacion e indicacion engloban ambos fenotipos de la enfermedad. Hasta ahora, el perfil de seguridad del ocrelizumab se ajusta a lo observado en los ensayos clinicos, sin alertas inesperadas.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Juanatey A,Blanco-Garcia L,Tellez Nsubject
Has Abstractpub_date
2018-06-16 00:00:00pages
423-433issue
12eissn
0210-0010issn
1576-6578pii
rn2018132journal_volume
66pub_type
杂志文章,评审abstract:INTRODUCTION:Cerebral infarction (CI) can be classified aetiologically in several different ways using explicit diagnostic criteria. However, the extent to which these diagnostic criteria are actually implemented in clinical practice is unknown. Aims. The aim of this study was to analyse the management and use of diagn...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Parkinson's disease is a neurodegenerative disorder associated with aging characterized by a motor extrapiramidal alteration secondary to the progressive death of dopaminergic neurons of the substantia nigra pars compacta. The cause of this neuronal loss remains unknown but post mortem studies on brains of parkinsonia...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-16 00:00:00
abstract:AIMS:The aim of this study was to determine whether the introduction of generic formulations of antiepileptic drugs (AED) would lead to an economic saving for the public health service. DEVELOPMENT:The narrow therapeutic index, low solubility and non-linear pharmacokinetics of some AED mean that the ranges of bioequiv...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract:INTRODUCTION:Epilepsy and the epileptic syndromes are common neurological diseases and represent an important public health problem that has given rise to marked social and healthcare concerns. AIM:To analyse the changes in the consumption of antiepileptic drugs in the Basque Country Autonomous Community over a 13 yea...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-04-16 00:00:00
abstract:INTRODUCTION:To study the role of the serotonin transporter gene (SLC6A4) in the emotional processing of auditory hallucinations can be particularly important to better understand the pathophysiology of auditory hallucinations. Moreover, a poly-morphism located in this gene (5-HTTLPR) has been previously associated wit...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2010-03-16 00:00:00
abstract:INTRODUCTION:Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal-dominant disorder of peripheral myelin characterized by episodes of recurrent mononeuropathies usually involving nerves at common sites of entrapment and compression. Additional features include evidence of a diffuse demyelinat...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-09-16 00:00:00
abstract:INTRODUCTION:Studies on focal dystonia showed that the formulations of botulinum toxin type A, incobotulinumtoxin-A (Inco-BTA) and onabotulinumtoxin-A (Ona-BTA), have equivalent efficacy and safety. AIM:To carry-out a cost-utility analysis of Inco-BTA administered on flexible intervals vs. Ona-BTA on a fixed interval,...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2018-12-16 00:00:00
abstract:INTRODUCTION:Orthostatic tremor is a rare kind of tremor which is clinically characterised by a feeling of instability or being about to fall that is experienced on standing up, which disappears or improves on walking and is absent when sitting or lying down. AIM:To shed light on the main features of this tremor syndr...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2012-04-01 00:00:00
abstract:AIM:To document reversible cognitive deterioration associated to high doses of zonisamide, using the Reliable Change Index to control practice effects derived from repetitive neuropsychological assessments. CASE REPORT:A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated wi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-01-16 00:00:00
abstract:INTRODUCTION:Status epilepticus (SE) is the most common neurological emergency on pediatric. Given the possibility of neurological sequelae and mortality associated, it requires an early aggressive treatment. PATIENTS AND METHODS:Retrospective descriptive study based on the review of medical histories of patients admi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Sleep and epilepsy have strong reciprocal influences and this is true for all kinds of epilepsies. The interictal paroxysmal activity increases in slow wave sleep and the localization of the primary epileptogenic area is more reliable in paradoxical sleep. DEVELOPMENT:From a practical point of view, an al...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-16 00:00:00
abstract:AIM:To analyse the data and concepts that have been produced in relation to one of the functions that have been suggested for sleep, namely, neuronal recovery. DEVELOPMENT:Sleep is a state of consciousness that is different to that of arousal. Mammals devote an important part of their lives to sleeping; for example, a...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-01 00:00:00
abstract::We studied 56 patients, 30 women and 26 men ranging from 30 to 79 years of age (average age 64.5 +/- 10.4), who were admitted to our hospital between 1982 and August 1995 with clinical features compatible with occlusion at the level of the bifurcation of the basilar artery. The patients were selected following clinica...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the therapeutic response of West's syndrome (WS) associated with cerebral paralysis (CP) secondary to periventricular leucomalacia (PVL). MATERIAL AND METHODS:We made a retrospective analysis of the clinical histories of 10 patients with SW and CP secondary to periventricular leucomalacia. We stu...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:INTRODUCTION:Primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (HPV) types 16 and 18, is now available worldwide. Postlicensure adverse neurological effects have been described. The studies realized after the license are descriptive and limi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-04-16 00:00:00
abstract:INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2015-05-16 00:00:00
abstract:INTRODUCTION:Strachan's disease is a condition which mainly affects the nervous system. It is characterized by optic, auditory and peripheral neuropathies and lesions of the skin and mucous membranes. In 1955 Miller Fisher gave it this name, since the clinical condition described by Henry Strachan in Jamaica during the...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:INTRODUCTION:A great deal of research has addressed problems in the correct acquisition of language, but with few overall conclusions. The reasons for this lie in the individual variability, the existence of different measures for assessing language and the fact that a complex network of genetic and environmental facto...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2017-01-01 00:00:00
abstract:TITLE:Parálisis súbita de la supraversión de la mirada en una niña de 9 años. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.7110.2020275
更新日期:2020-11-16 00:00:00
abstract:INTRODUCTION:The progress made in perinatal health care in recent years has changed the epidemiology of neurological diseases during the neonatal period. The reduction in neonatal mortality has been accompanied by an increasingly large number of patients suffering from disabling diseases or with a risk of suffering fro...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::In this study we approach problems related to the dosage and specific action of methylphenidate, its effects at cognitive and social levels, possible side-effects and limitations to its usage, and methods for evaluation of the response to treatment in the school environment. We make special mention of the importance o...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract:INTRODUCTION:Piribedil is a D2 D3 dopamine agonist, which has been shown to be well tolerated and to improve Parkinsonian symptoms, particularly tremor. However, few studies have been published about this Dopamine Agonist as an adjunct to levodopa therapy in patients with Parkinson's disease (PD). This placebo controll...
journal_title:Revista de neurologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-04-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Attention deficit hyperactivity disorder (ADHD) is one of the most frequently observed processes in our Neuropaediatric unit, and in recent years has become one of the leading reason for visits, together with headaches. On occasions, the diagnosis that should be made, in accordance with the...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract:AIM:To identify the clinical features that predict a favourable response to onabotulinumtoxinA (OnabotA) treatment in patients with refractory migraine. PATIENTS AND METHODS:Retrospective analysis of patients with refractory migraine who underwent at least two pericranial injections of OnabotA between 2008 and 2012. P...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-03-16 00:00:00
abstract:INTRODUCTION:Glutaric aciduria type I is an autosomal recessive inborn error of metabolism that is due to a deficiency of the enzyme glutaryl-CoA dehydrogenase, which gives rise to an accumulation of glutaric and 3-hydroxyglutaric acids in biological fluids. Clinical features present as a sudden-onset severe neurologic...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-05-16 00:00:00
abstract:INTRODUCTION:A large number of diseases present as bilateral striatal lesion syndrome (BSLS). Clinical manifestations, course and prognosis of these diseases are extremely variable. On the basis of their evolutive course, they can be separated into two major groups: acute, which include toxic, infectious or parainfecti...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-12-16 00:00:00
abstract:INTRODUCTION:The signals obtained during conventional needle examination are usually assessed subjectively by the neurophysiologist. Buchthal's approach allows quantification of several motor unit parameters during mild effort. DEVELOPMENT:The automatic methods of analysis of the EMG interference pattern (IP), in part...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-03-16 00:00:00
abstract:OBJECTIVE:To review about this disorder, with emphasis on the intensive care of severe Guillain Barr syndrome (GBS). DEVELOPMENT:GBS is an acute immune mediated inflammatory polyneuropathy that may lead to quadriparesis, ventilatory failure, and autonomic dysfunction but also to many general medical problems that have...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2002-05-16 00:00:00
abstract:INTRODUCTION:Head tremor, either as an isolated symptom or as part of a symptomatic complex, occurs in patients with different neurological diseases. Little research has been carried out to analyse the clinical features of this neurological symptom. AIM:To review the symptomatology, aetiology and therapeutics of brain...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2010-06-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Isolated mental retardation is rarely caused by metabolic factors. The application of a standardised protocol offers low diagnostic performance. There is no international agreement about what type of metabolic examination must be applied in patients with unspecific mental retardation. Never...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-10 00:00:00