Abstract:
INTRODUCTION:Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy. It has several side effects and is associated to increased body weight, as well as metabolic and endocrine disorders, including metabolic syndrome. AIM:To determine the prevalence of obesity and metabolic syndrome among paediatric patients with epilepsy treated in monotherapy with VPA. PATIENTS AND METHODS:The study was cross-sectional, observational and analytical. A sample of patients treated with VPA between 2010-2014 were studied and the body mass index (BMI), abdominal perimeter, arterial blood pressure, glucose, triglycerides and high density lipoproteins (HDL) were studied in search of obesity and metabolic syndrome. Obesity was defined as a BMI above the 95th percentile, and metabolic syndrome was considered if at least three of the following criteria were fulfilled: abdominal perimeter above the 90th percentile, systolic arterial pressure above the 90th percentile, triglycerides above 110 mg/dL and HDL below 40 mg/dL. RESULTS:A total of 47 patients with a mean age of 10.1 ± 4 years were studied; 51.06% were males. Eight (17%) of them developed obesity and, of those, two (25%) had metabolic syndrome. Three patients went on to become overweight (6%). Statistically significant differences were observed in the mean age in comparison to the BMI groups, where the obese patients were adolescents (ANOVA, p = 0.0001) and those who took more VPA per day were the obese (ANOVA, p = 0.024). CONCLUSIONS:Patients treated with VPA who become obese may go on to develop metabolic syndrome. They require careful monitoring and, if they are seen to put on weight, withdrawal of the drug should be considered. TITLE:Prevalencia de obesidad y sindrome metabolico en pacientes pediatricos con epilepsia tratados en monoterapia con acido valproico. :Introduccion. El acido valproico (VPA) es un antiepileptico util para controlar diferentes tipos de epilepsia. Tiene efectos colaterales y se asocia a incremento del peso corporal y a alteraciones metabolicas y endocrinas, entre ellas sindrome metabolico. Objetivo. Conocer la prevalencia de la obesidad y el sindrome metabolico en pacientes pediatricos con epilepsia tratados en monoterapia con VPA. Pacientes y metodos. Estudio transversal, observacional, analitico. Se estudiaron pacientes tratados con VPA entre 2010-2014, y se midio el indice de masa corporal (IMC), el perimetro abdominal, la presion arterial, la glucosa, los trigliceridos y las lipoproteinas de alta densidad (HDL), en busqueda de obesidad y sindrome metabolico. La obesidad se definio con un IMC mayor del percentil 95; el sindrome metabolico, con al menos tres de los siguientes criterios: perimetro abdominal mayor del percentil 90, presion arterial sistemica mayor del percentil 90, trigliceridos mayores de 110 mg/dL y HDL menor de 40 mg/dL. Resultados. Se estudiaron 47 pacientes con una edad media de 10,1 ± 4 años; el 51,06% eran varones. Ocho (17%) desarrollaron obesidad y, de ellos, dos (25%), sindrome metabolico. Tres pacientes desarrollaron sobrepeso (6%). Observamos diferencias estadisticamente significativas de media de edad comparados con los grupos de IMC, donde los pacientes obesos eran adolescentes (ANOVA; p = 0,0001), y aquellos que tomaban mas VPA al dia eran los obesos (ANOVA; p = 0,024). Conclusiones. Los pacientes tratados con VPA que se convierten en obesos pueden desarrollar sindrome metabolico. Requieren una monitorizacion cuidadosa y, ante la presencia de ganancia de peso, se debera valorar la retirada del farmaco.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Carmona-Vazquez CR,Ruiz-Garcia M,Pena-Landin DM,Diaz-Garcia L,Greenawalt SRsubject
Has Abstractpub_date
2015-09-01 00:00:00pages
193-201issue
5eissn
0210-0010issn
1576-6578pii
rn2015134journal_volume
61pub_type
杂志文章abstract:INTRODUCTION:It is necessary to know the degree of concordance of preoperative studies in temporal lobe epilepsy (TLE). AIM. To analyze the relative importance of different preoperative tests (vEEG, EEG, SPECT and MRI), the degree of agreement between them, and to develop a Bayesian probability model for diagnosis. PA...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION:Dysraphias are a varied set of anomalies affecting neuroectodermic tissue caused by the alteration of the neural tube during embryogenesis. Neuroradiological classification is broad and clinical manifestations are numerous: they affect the skin, osteomuscular tissue and the vascular, urological and nervous...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:INTRODUCTION:Most patients with Parkinson's disease have cognitive and behavior disorders during the course of their illness. OBJECTIVE:In this study we consider practical aspects of the treatment of patients with Parkinson's disease who have such problems. DEVELOPMENT:Better understanding of both normal and abnormal...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Isolated mental retardation is rarely caused by metabolic factors. The application of a standardised protocol offers low diagnostic performance. There is no international agreement about what type of metabolic examination must be applied in patients with unspecific mental retardation. Never...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-10 00:00:00
abstract:OBJECTIVE:To investigate some immune component that could contribute to the pathogenesis of Alzheimer's disease associated with the E280A mutation of the presenilin-1 gene (PS-1). PATIENTS AND METHODS:Serum antibodies against both cardiolipin and beta-amyloid peptides (beta 1-40 and beta 1-42) were quantitated by mean...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-12-16 00:00:00
abstract:INTRODUCTION:Brain creatine deficiencies are a group of inborn errors of metabolism recently recognized which are caused by arginine: glycine amidinotransferase (AGAT) deficiency, guanidinoacetate metiltransferase (GAMT) deficiency and defects in creatine transporter (CRTR). Although all of them are characterized by a ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-03-16 00:00:00
abstract:TITLE:Encefalitis multifocal como manifestación neurológica de la infección por COVID-19. ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.7109.2020226
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Diverse evidences have shown that the process of natural aging causes a decline in different cognitive functions, including among them the attentional process. AIM:To determine how the healthy aging affects to the different attentional networks. SUBJECTS AND METHODS:Two groups: young subjects (32.5 ± 9.7...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:There is a correlation between the higher brain functions and the degree of development of the associated cortices, but their efficiency depends on the patterns of cytoarchitectural organisation. Specialised areas can be distinguished in the neocortex and in the thalamus. Portions of the pa...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-01-15 00:00:00
abstract:INTRODUCTION:Several studies that has focused to the dopaminergic transmission in the basal ganglia in parkinsonian condition, but only a few article has taking into account the imbalance between dopaminergic and cholinergic transmission. OBJECTIVE:To evaluate the muscarinic cholinergic receptors density in SNc and PP...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-01-16 00:00:00
abstract:INTRODUCTION:The relationship between headache and sleep is complex and runs in two directions. Headache may be the consequence of a (primary or secondary) sleep disorder or its cause (in chronic tension-type headache and/or chronic migraine with or without painkiller abuse). It can also be related to sleep in an intri...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-09-16 00:00:00
abstract:AIM:The aim is to review the molecular and genetic aspects of the dystrophic and no dystrophic myotonias. BACKGROUND:Myotonic diseases are hereditary conditions of the skeletal muscle, classified in two groups depending on the symptoms. In the first group are the myotonic dystrophies, with the myotonic dystrophies typ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:Critical illness patients may show marked weakness acquired in the Intensive Care Unit (ICU). There are some disagreements about the myopathic versus neuropathic damage in this condition, presumably due to the lack of reliable diagnostic criteria. AIMS:To report the neurophysiological findings in critical...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2010-06-16 00:00:00
abstract:INTRODUCTION:The Kamayura tribe is made up of 300 persons living in the Alto Xingu in Mato Grosso, Brazil. Their traditional system of health care is based on the pajé, a witch doctor who uses plants and prayers for treatment. MATERIAL AND METHODS:Field work was done in the Kamayura village holding successive intervie...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract:INTRODUCTION:Primary peptidergic sensory neurons of the trigeminal ganglion that innervate the cerebral dura have been involved in the pathogenesis of headache, including the migraine. In addition, it is known that nociceptive central processes of the trigeminal neurons terminate in the caudal trigeminal nucleus. Moreo...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-04-16 00:00:00
abstract::There are several syndromes in which neurological and cutaneous alterations of vascular origin, among other symptoms, occur. The key point of this fact is that these cutaneous signs permit early diagnosis, thus helping in further recognition of more complex syndromes and preventing unnecessary, harmful and costly diag...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract:INTRODUCTION:Self-awareness impairment is a common symptom of patients after suffering acquired brain injury, affecting the rehabilitation process and achievements in terms of patients's daily living functionality. PATIENTS AND METHODS:A systematic review was performed using Scopus and PubMed databases of scientific a...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:10.33588/rn.7001.2019313
更新日期:2020-01-01 00:00:00
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journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The amygdala is related with the recognition of the emotional meaning of stimuli, long-term memory, the orientation of social stimuli and the perception of gaze orientation. It plays a fundamental role in the recognition of faces, especially those expressing fear, and makes it possible to comprehend different emotiona...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-24 00:00:00
abstract:INTRODUCTION:CLIPPERS syndrome (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is an inflammatory process of the central nervous system whose distinguishing features are the enhancing punctiform lesions in the brainstem that appear in the magnetic resonance images. Clinic...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2013-10-16 00:00:00
abstract:INTRODUCTION:A good deal of evidence currently exists to show that transplanting foetal mesencephalic tissue can produce symptomatic benefits both in patients and in disease models. Nevertheless, the technical and ethical difficulties involved in obtaining enough suitable foetal cerebral tissue have been a serious obst...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-08-16 00:00:00
abstract:INTRODUCTION:The term «gossypiboma» comes from the Latin gossypium, which refers to a genus of cotton plants, and from the Swahili word boma, which translates as «place of concealment». It may be mistaken for tumorous lesions or abscesses due to the way it is encapsulated, as evidenced in imaging examinations, and its ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6909.2019282
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:As result of our aim to improve the quality standard of our emergency system, work has been carried out in relation to the development and monitorization of effective clinical protocols in the department of paediatric practice. PATIENTS AND METHODS:An evidence based review approach was taken to design a c...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-08-16 00:00:00
abstract::Brainstem dysgenesis designates all those patients with congenital dysfunction of cranial nerves and muscle tone due to prenatal lesions or malformations of the brainstem. This generic term has the advantage over the eponyms Moebius 'expanded' or 'unrestricted', Robin, Cogan or Carey-Fineman-Ziter syndromes in that it...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To carry out a bibliographic review of articles indexed in MEDLINE over the past 20 years concerning the pharmacological treatment of agitation in head injury. DEVELOPMENT:Head injury may cause different behaviour changes, of which agitation is the most dramatic. The incidence of agitation after severe head ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract:INTRODUCTION:Neurotoxoplasmosis (NTX) is one of the commonest opportunist infections in patients infected by the human immunodeficiency virus. It presents with a variety of clinical features in the immunocompromised patient. PATIENTS AND METHODS:We made a horizontal retrospective descriptive study of 88 patients with ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract:INTRODUCTION:Both cognitive psychology and neuropsychology require an approach to the multidimensional 'attention'. DEVELOPMENT:Attention permits behaviour to be suitable to the task in hand. According to the situation or activity required, the components or mechanisms of attention necessary vary (selectivity, alertne...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-03-01 00:00:00
abstract:TITLE:Signo del cerebelo blanco (reversal sign). : ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Visual phenomena can be symptoms of epileptic seizures, although with an uncertain clinical meaning and relationship with the epileptogenic focus. AIMS:To describe the clinical implications of visual epileptic seizures according to their signs and symptoms in adults. PATIENTS AND METHODS:Data were collec...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-03-16 00:00:00
abstract:INTRODUCTION:Epilepsy is a common disease with important social and economic repercussions. Patients with epilepsy have traditionally been discriminated by both the general population and physicians. A physician's lack of knowledge about epilepsy could be the cause of an incorrect clinical control (CC). AIMS:The purpo...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00