Abstract：
OBJECTIVE:To investigate some immune component that could contribute to the pathogenesis of Alzheimer's disease associated with the E280A mutation of the presenilin-1 gene (PS-1). PATIENTS AND METHODS:Serum antibodies against both cardiolipin and beta-amyloid peptides (beta 1-40 and beta 1-42) were quantitated by means of an indirect ELISA technique in carriers of the mutation, either healthy or with Alzheimer's disease, as well as in normal controls without the mutation. RESULTS:Out of 19 patients with Alzheimer's disease only 2 had increased values of antibodies to cardiolipin, namely: one with 14.58 micrograms/ml of IgM and the other with 36.16 micrograms/ml of IgG. The remaining individuals revealed values under 10 micrograms/ml, considered normal, and there was no significant difference between the groups. Significant serum reactivity (p < 0.001) was detected against both beta-amyloid peptides in the mutation carriers, either with or without Alzheimer's disease, as compared to the control group. No correlation was detected between this antibody response and the mental or functional situation of the patients. CONCLUSION:beta-amyloid antibodies, present in the mutation carriers, may simply represent a marker of immune activation induced by beta-amyloid with no in vivo effect; however, despite the results, the possibility can not be ruled out of a pathogenic role of these antibodies in early onset Alzheimer's disease.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Toro F,Lopera F,Ossa J,Madrigal L,Mira A,Díaz A,Parra Ssubject
Has Abstractpub_date
1999-12-16 00:00:00pages
1104-7issue
12eissn
0210-0010issn
1576-6578journal_volume
29pub_type
杂志文章abstract：INTRODUCTION:Throughout history a number of speculations have been put forward concerning the functional role of the pineal gland, perhaps some of the most important being the neurophysiological proposals by Descartes. DEVELOPMENT:The psychophysiological role conferred on the pineal gland by Descartes in the 17th cent...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2010-01-16 00:00:00
abstract：INTRODUCTION:Sneddon syndrome is the association of livedo retricularis and cerebrovascular lesions. It is a vasculopathy of vessels of small and medium calibre which affects young people and is of unknown origin. It is often associated with arterial hypertension and repeated ischemic cerebrovascular accidents which le...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：INTRODUCTION:Status epilepticus (SE) is the most common neurological emergency on pediatric. Given the possibility of neurological sequelae and mortality associated, it requires an early aggressive treatment. PATIENTS AND METHODS:Retrospective descriptive study based on the review of medical histories of patients admi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2015-05-01 00:00:00
abstract：AIM:To review the neurochemical features and therapeutic options for frontotemporal dementia (FTD). DEVELOPMENT:The main neurochemical alterations in FTD are the serotoninergic and dopamine depletion. In contrast with Alzheimer's and diffuse Lewy bodies disease, there are not significant alterations of the cholinergic...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Primary care professionals need useful and simple tools to detect early cognitive impairment in patients with any clinical suspicion of dementia. AIM. This critical review attempts to analyze the psychometric properties of cognitive screening tests, commonly used for screening dementia in primary care sett...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:The term 'frontotemporal lobar dementia' (FTLD) covers a group of neurodegenerative diseases that are very heterogeneous in their clinical expression, genetic component and histopathological features, and this has traditionally made it difficult to study and classify them. Patients usually present a progre...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:Decrease in incidence of neurosyphilis over the last few decades implies that clinicians consider less frequently this diagnosis. On the other hand, some reports suggest an increase in atypical forms of this disease that represent an additional reason for missing this diagnosis. CLINICAL CASE:We report on...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-09-16 00:00:00
abstract：AIM:To report one patient with slowly progressive encephalopathy, ataxia, central hypomyelination, hypodontia and hypogonadotropic hypogonadism, the 4H syndrome. This clinical picture has been described recently and there are only four patients reported previously. CASE REPORT:A girl with a previously normal early psy...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-08-16 00:00:00
abstract：:Optical coherence tomography (OCT) is a non-invasive imaging technique that allows the different layers of the retina to be visualised in vivo. One of them is the so-called retinal nervous fibre layer (RNFL), which is made up of amyelinic axons from the ganglionic cells, and therefore part of the central nervous syste...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-05-01 00:00:00
abstract：INTRODUCTION:The developmental amnesia is a recently known entity that occurs as a consequence of hypoxic-ischemic events in the perinatal period. This is a specific deficit of episodic memory with greater preservation of semantic memory and other memory components such as the immediate and working memory. It occurs in...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:In Parkinson's disease there are patients with isolated and multiple cognitive impairment, and their cognitive performance ranges from normal to an advanced degree of dementia. Most patients present an executive deficit, either in isolation or combined with other cognitive disorders, which is considered to...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-08 00:00:00
abstract：AIM:To analyze the safety profile and clinical outcome of patients with acute cerebral ischemia who received open treatment with tissue plasminogen activator (rt-PA) in a hospital without previous experience. PATIENTS AND METHODS:This prospective and observational study were realized from January 2004 to January 2007....
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:FOXP2 is the first gene linked to a hereditary variant of specific language impairment and seems to code for a transcriptional repressor that intervenes in the regulation of the development and the functioning of certain thalamic-cortical-striatal circuits. DEVELOPMENT:In the last three years, significant...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-03-16 00:00:00
abstract：OBJECTIVE:To review the mechanisms involved in the appearance of respiratory failure in patients with neuromuscular disorders. DEVELOPMENT:The development of respiratory failure in patients with weakness of the respiratory muscles secondary to neuromuscular disease is not only due to the disease itself. There are also...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:The incidence in the central nervous system diseases has increased with a growing elderly population. Unfortunately, conventional treatments used to treat the mentioned diseases are frequently ineffective due to the presence of the blood brain barrier. AIM:To illustrate the blood-brain barrier properties ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:The chronic inflammatory demyelinating polyneuropathy (CIDP) is a controversial sickness. No doubt it is still a diagnosis without a strict nosologic delimitation until we acquire a greater knowledge about the underlying mechanisms, or whether a specific marker is found. We evaluated its clin...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1999-04-16 00:00:00
abstract：TITLE:Meningoencefalitis tuberculosa con quistes aracnoideos medulares y siringomielia aguda. ...
journal_title：Revista de neurologia
pub_type： 信件
doi：
更新日期：2017-10-16 00:00:00
abstract：TITLE:Signo del tridente en la neurosarcoidosis medular. : ...
journal_title：Revista de neurologia
pub_type：
doi：10.33588/rn.7005.2019180
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:Numerous drugs have been related to exacerbation of myasthenia gravis. So far there are no studies examining the extent of use of drugs related to exacerbation of myasthenia gravis. AIMS:We sought to assess the extent of use of drugs related to exacerbations and the annual incidence rate of exacerbations ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7104.2020198
更新日期：2020-08-16 00:00:00
abstract：INTRODUCTION:Duchenne/Becker muscular dystrophy (DMD/B) is one of the commonest myopathies, with an incidence of 1/3,500 male live births. It is characterized by the slow degeneration of muscle fibres, so that the patient has become an invalid by the age of 10 years, followed by death from respiratory or cardiac failur...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:Surgery for resection of supratentorial lesions near the motor areas and/or internal capsule carries an associated risk of damage to cortical or subcortical motor pathways. Intraoperative brain mapping, using direct cortical electric stimulation, is a surgical adjunct used during lesionectomy in functional...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-06-16 00:00:00
abstract：:It has been stated that findings in neonatal neurological examinations can play a role as a pointer to adverse developmental outcome. The description of the examinations, and their presence or absence differed among authors without clear reference to their physiological variability ranges. We approached the study of s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
abstract：:The lack of univocal diagnostic biological markers which are easily reproducible, highly specific and sensitive has propitiated the apparition of a conjunct of neuropsychological instruments for the detection and evaluation of dementias. The main markers are reviewed in this paper, the third of three papers dedicated ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION AND DEVELOPMENT:There is a correlation between the higher brain functions and the degree of development of the associated cortices, but their efficiency depends on the patterns of cytoarchitectural organisation. Specialised areas can be distinguished in the neocortex and in the thalamus. Portions of the pa...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-01-15 00:00:00
abstract：INTRODUCTION:In the treatment of speech disorders by means of speech therapy two antagonistic methodological approaches are applied: non-verbal ones, based on oral motor exercises (OME), and verbal ones, which are based on speech processing tasks with syllables, phonemes and words. In Spain, OME programmes are called '...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-01-01 00:00:00
abstract：CASE REPORT:We report the case of an infant with septo-optic dysplasia, or Morsier's syndrome, which is a condition affecting the central nervous system that can only be confirmed by means of neuroimaging. This syndrome involves hypoplasia of one or both optic nerves, absence of septum pellucidum, agenesis of the corpu...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:Depression is a state of mind often associated with Parkinson's disease, which is not correlated with the stage of the disease or the response to treatment with L-dopa. It has been suggested that patients with right-sided Parkinsonism have more depression than those with left-sided. OBJECTIVE:To assess wh...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-12-16 00:00:00
abstract：OBJECTIVE:To evaluate the therapeutic response of West's syndrome (WS) associated with cerebral paralysis (CP) secondary to periventricular leucomalacia (PVL). MATERIAL AND METHODS:We made a retrospective analysis of the clinical histories of 10 patients with SW and CP secondary to periventricular leucomalacia. We stu...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：TITLE:Signo del cerebelo blanco (reversal sign). : ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
